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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzenamine, hydrochloride

RTECS #

CY0875000

CAS #

142-04-1

Updated

December 2013

Molecular Weight

129.60

Molecular Formula

C6H7N·ClH

Synonyms

Aniline chloride
Aniline hydrochloride (6CI,8CI)
Anilinium chloride
C.I. 76001
Chlorhydrate d'aniline (French)
Chlorid anilinu (Czech)
NCI-C03736 hydrochloride
Phenylamine hydrochloride
Phenylammonium chloride
Sul anilinova (Czech)
USAF EK-442

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,459,1986
skin /rabbit 500 mg/24H moderate28ZPAK -,65,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse1000 mg/kgHPV371 -,-,2006
DNA Damageoral/rat907.2 mg/kg/7D- intermittentJTEHF8 68,657,2005
micronucleus testoral/rat300 mg/kgARTODN 77,291,2003
micronucleus testintraperitoneal/mouse1 gm/kgCRNGDP 12,1057,1991
morphological transformembryo/rat79500 ng/plateJJATDK 1,190,1981
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster5 pphMUREAV 413,15,1998
sister chromatid exchangefibroblast/hamster10 µmol/LJNCIAM 58,1635,1977
sister chromatid exchangelymphocyte/human50 µmol/LBLFSBY 29B,561,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1400 mg/kg (7-20D pregnant)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)TXAPA9 77,465,1985
oral/rat 1400 mg/kg (7-20D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
NTIS** OTS0555028
oral/rat 140 mg/kg (7-20D pregnant)Reproductive: Other effects on femaleHPV371 -,-,2006
oral/rat 1400 mg/kg (7-20D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV371 -,-,2006
subcutaneous/rat 780 mg/kg (19-21D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 52,14B,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 130 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Blood: Tumors
NCITR* NCI-TR-130,1978
oral/rat toxic dose: 238 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Blood: Tumors
NCITR* NCI-TR-130,1978
oral/rat toxic dose: 137 gm/kg/60W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
IMEMDT 27,39,1982
oral/rat toxic dose: 2163 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
IMEMDT 27,39,1982
oral/rat toxic dose: 4326 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
IMEMDT 27,39,1982
oral/rat lowest published toxic dose: 72800 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV371 -,-,2006
oral/rat lowest published toxic dose: 108150 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV371 -,-,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 460 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaJPETAB 80,31,1944
oral/mouse lethal dose (50 percent kill): 841 mg/kgNTIS** PB214-270
oral/rat lethal dose (50 percent kill): 840 mg/kgTXAPA9 42,417,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 440 mg/kg/2D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor
MOCAT* 18,283,2003
intraperitoneal/mouse lowest published toxic dose: 760 mg/kg/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldMOCAT* 18,283,2003
oral/rat lowest published toxic dose: 907 mg/kg/7D- intermittentBlood: Changes in spleen

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 194,95,2003
oral/rat lowest published toxic dose: 1944 mg/kg/30D- intermittentBlood: Changes in spleen

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 203,36,2005
oral/rat lowest published toxic dose: 70 mg/kg/1W- intermittentBlood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 77,672,2003
oral/rat lowest published toxic dose: 1944 mg/kg/30D- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen
TOXID9 1,49,2001
oral/rat lowest published toxic dose: 1944 mg/kg/30D- continuousBlood: Changes in spleen

Biochemical: Metabolism (intermediary): Other
TOXID9 78,307,2004
oral/rat lowest published toxic dose: 907 mg/kg/7D- intermittentBlood: Changes in spleen

Biochemical: Metabolism (intermediary): Other
TOXID9 78,308,2004
oral/rat lowest published toxic dose: 1944 mg/kg/30D- intermittentBlood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 210,86,2006
oral/rat lowest published toxic dose: 1944 mg/kg/30D- continuousBlood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
TXAPA9 210,86,2006
oral/rat lowest published toxic dose: 700 mg/kg/1W- continuousEndocrine: Changes in spleen weight

Blood: Other hemolysis with or without anemia

Blood: Changes in leukocyte (WBC) count
HETOEA 23,379,2004
oral/rat lowest published toxic dose: 840 mg/kg/4W- continuousEndocrine: Changes in spleen weight

Blood: Other hemolysis with or without anemia

Blood: Changes in spleen
HETOEA 23,379,2004
oral/rat lowest published toxic dose: 210 mg/kg/1W- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen

Blood: Other changes
HETOEA 23,379,2004
oral/rat lowest published toxic dose: 2800 mg/kg/4W- continuousLiver: Other changes

Endocrine: Changes in spleen weight

Blood: Changes in bone marrow not included in above
HETOEA 23,379,2004
oral/rat lowest published toxic dose: 280 mg/kg/4W- continuousBlood: Changes in spleenHETOEA 23,379,2004
oral/rat lowest published toxic dose: 907.2 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Metabolism (intermediary): Other
JTEHF8 68,657,2005
oral/rat lowest published toxic dose: 1944 mg/kg/30D- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
TXAPA9 250,213,2011
oral/rat lowest published toxic dose: 1944 mg/kg/30D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in spleen
TOXID9 42,150,1998
oral/rat lowest published toxic dose: 1800 mg/kg/90D- continuousEndocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
AECTCV 24,368,1993
oral/rat lowest published toxic dose: 910 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in spleen

Nutritional and Gross Metabolic: Changes in: Fe
FAATDF 35,22,1997

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 27,39,1982
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FRANCEVME 7.6 mg/m3, Skin, C3 Carcinogen, FEB2006

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M2301; Number of Industries 58; Total Number of Facilities 5101; Number of Occupations 38; Total Number of Employees Exposed 82371; Total Number of Female Employees Exposed 47136
National Occupational Hazard Survey 1974Hazard Code M2301; Number of Industries 3; Total Number of Facilities 136; Number of Occupations 2; Total Number of Employees Exposed 260

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:ratNCITR* NCI-TR-130,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouseNCITR* NCI-TR-130,1978
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