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Benzene, bromo -

RTECS #: CY9000000

CAS #: 108-86-1


UPDATE: February 2009 MW: 157.02 MF: C6H5Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Monobromobenzene
  2. NCI - C55492
  1. Phenyl bromide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Escherichia coli 250 mg/L JJIND8 62,873,1979
micronucleus test intraperitoneal
mouse
125 mg/kg/24 hour MUTAEX 2,111,1987
sister chromatid exchange hamster ovary 500 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 14,400 mg/m3 N/R GTPZAB 18(4),55,1974
inhalation
mouse
lethal concentration (50 percent kill): 21 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 13(9),56,1969
inhalation
rat
lethal concentration (50 percent kill): 20,411 mg/m3 N/R GTPZAB 19(9),36,1975
inhalation
rat
lowest published toxic concentration: 250 mg/m3 Blood: Changes in cell count (unspecified) VCVGK* -,47,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 817 mg/kg N/R MUTAEX 2,111,1987
intraperitoneal
mouse
lowest published lethal dose: 0.5 mL/kg N/R TOSCF2 73,220,2003
intraperitoneal
mouse
lethal dose : 0.5 mg/kg N/R TOXID9 44,13,2005
intraperitoneal
mouse
lowest published lethal dose: 112 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 44,15,2005
intraperitoneal
mouse
lethal dose (80 percent kill): 0.5 mL/kg N/R JPETAB 316,507,2006
intraperitoneal
mouse
lowest published toxic dose: 753.7 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 243,249,2008
intraperitoneal
rat
lethal dose (50 percent kill): 3,882 mg/kg N/R TXAPA9 83,108,1986
intraperitoneal
rat
lowest published toxic dose: 750 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase
VCVGK* -,47,1984
intraperitoneal
rat
lowest published toxic dose: 785.1 mg/kg Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCPCA6 65,857,2003
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTPAE7 18,189,2005
oral
guinea pig
lethal dose (50 percent kill): 1,700 mg/kg N/R 85GMAT -,28,1982
oral
mammal (species unspecified)
lethal dose (50 percent kill): 2,700 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 2,700 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 13(9),56,1969
oral
rat
lethal dose (50 percent kill): 2,383 mg/kg Eye: Chromodacryorrhea

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571670
oral
rat
lowest published toxic dose: 300 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,469,2007
oral
rat
lowest published toxic dose: 300 mg/kg Liver: Other changes TXCYAC 250,15,2008
oral
rabbit
lethal dose (50 percent kill): 3,300 mg/kg N/R 85GMAT -,28,1982
subcutaneous
mouse
lethal dose (50 percent kill): 2 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes
JJPAAZ 3,99,1954
unreported route
mouse
lethal dose (50 percent kill): 2,700 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,47,1984
unreported route
rat
lethal dose (50 percent kill): 3,200 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,47,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/45 day- intermittent Blood: Luekopenia VCVGK* -,48,1994
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/90 day- intermittent Brain and Coverings: Other degenerative changes VCVGK* -,48,1994
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,48,1994
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,48,1994
intraperitoneal
mouse
lowest published toxic dose: 3,768 mg/kg/18 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTEHD6 21,325,1987
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/4 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JTPAE7 18,189,2005
intraperitoneal
rat
lowest published toxic dose: 1,350 mg/kg/9 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JTSCDR 32,129,2007
unreported route
rat
lowest published toxic dose: 16 mg/kg/5 day/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
VCVGK* -,48,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,344,2005
TOXICOLOGY REVIEW
EJPHAZ 549,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83863;
Number of Industries 5;
Total Number of Facilities 105;
Number of Occupations 9;
Total Number of Employees Exposed 18,936
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83863;
Number of Industries 2;
Total Number of Facilities 64;
Number of Occupations 3;
Total Number of Employees Exposed 1,891;
Total Number of Female Employees Exposed 238


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a chemical intermediate

NIOSH PROFILE (AROMATIC COMPOUNDS, BROMINATED), SRC, 10/77

RTECS Compound Description:
   Mutagen

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