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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzene, bromo-

RTECS #

CY9000000

CAS #

108-86-1

Updated

December 2013

Molecular Weight

157.02

Molecular Formula

C6H5Br

Synonyms

Monobromobenzene
NCI-C55492
Phenyl bromide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/human1 mmol/l/48HMUREAV 696,21,2010
DNA repair/Escherichia coli250 mg/LJJIND8 62,873,1979
micronucleus testintraperitoneal/mouse125 mg/kg/24HMUTAEX 2,111,1987
micronucleus testoral/rat1200 mg/kgMUREAV 698,30,2010
sister chromatid exchangeovary/hamster500 mg/LEMMUEG 10(Suppl 10),1,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2400 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 5.7 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 14400 mg/m3GTPZAB 18(4),55,1974
inhalation/mouse lethal concentration (50 percent kill): 21 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 13(9),56,1969
inhalation/rat lethal concentration (50 percent kill): 20411 mg/m3GTPZAB 19(9),36,1975
inhalation/rat lowest published toxic concentration: 250 mg/m3Blood: Changes in cell count (unspecified)VCVGK* -,47,1984
intraperitoneal/mouse lowest published lethal dose: 0.5 mL/kgTOSCF2 73,220,2003
intraperitoneal/mouse lowest published lethal dose: 112 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 44,15,2005
intraperitoneal/mouse lethal dose (80 percent kill): 0.5 mL/kgJPETAB 316,507,2006
intraperitoneal/mouse lowest published toxic dose: 753.7 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 243,249,2008
intraperitoneal/mouse lethal dose (50 percent kill): 817 mg/kgMUTAEX 2,111,1987
intraperitoneal/mouse lowest published lethal dose: 0.5 mg/kgTOXID9 44,13,2005
intraperitoneal/rat lethal dose (50 percent kill): 3882 mg/kgTXAPA9 83,108,1986
intraperitoneal/rat lowest published toxic dose: 150 mg/kgLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTPAE7 18,189,2005
intraperitoneal/rat lowest published toxic dose: 750 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase
VCVGK* -,47,1984
intraperitoneal/rat lowest published toxic dose: 785.1 mg/kgLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCPCA6 65,857,2003
oral/guinea pig lethal dose (50 percent kill): 1700 mg/kg85GMAT -,28,1982
oral/mammal (species unspecified) lethal dose (50 percent kill): 2700 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 2700 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity
GTPZAB 13(9),56,1969
oral/rabbit lethal dose (50 percent kill): 3300 mg/kg85GMAT -,28,1982
oral/rat lethal dose (50 percent kill): 2383 mg/kgEye: Chromodacryorrhea

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571670
oral/rat lowest published toxic dose: 300 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,469,2007
oral/rat lowest published toxic dose: 300 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 247,211,2010
oral/rat lowest published toxic dose: 100 mg/kgLiver: Other changesTXAPA9 247,211,2010
oral/rat lowest published toxic dose: 1570.2 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
FCTOD7 48,2170,2010
subcutaneous/mouse lethal dose (50 percent kill): 2 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes
JJPAAZ 3,99,1954
unreported route/mouse lethal dose (50 percent kill): 2700 mg/kgBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,47,1984
unreported route/rat lethal dose (50 percent kill): 3200 mg/kgBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,47,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/45D- intermittentBlood: LuekopeniaVCVGK* -,48,1994
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/90D- intermittentBrain and Coverings: Other degenerative changesVCVGK* -,48,1994
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/122D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,48,1994
inhalation/rat lowest published toxic concentration: 20 mg/m3/4H/122D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductVCVGK* -,48,1994
intraperitoneal/mouse lowest published toxic dose: 3768 mg/kg/18D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTEHD6 21,325,1987
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/4D- intermittentLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JTPAE7 18,189,2005
intraperitoneal/rat lowest published toxic dose: 1350 mg/kg/9D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JTSCDR 32,129,2007
oral/rat lowest published toxic dose: 3220 mg/kg/7D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
FCTOD7 47,1584,2009
unreported route/rat lowest published toxic dose: 16 mg/kg/5D/4W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
VCVGK* -,48,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,344,2005
TOXICOLOGY REVIEWEJPHAZ 549,1,2006
TOXICOLOGY REVIEWTXAPA9 243,154,2010
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83863; Number of Industries 2; Total Number of Facilities 64; Number of Occupations 3; Total Number of Employees Exposed 1891; Total Number of Female Employees Exposed 238
National Occupational Hazard Survey 1974Hazard Code 83863; Number of Industries 5; Total Number of Facilities 105; Number of Occupations 9; Total Number of Employees Exposed 18936

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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