CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Benzeneacetic acid, 4 - chloro - alpha - (1 - methylethyl) - , cyano (3 - phenoxyphenyl) methyl ester

RTECS #: CY1576350

CAS #: 51630-58-1

UPDATE: May 2009 MW: 419.93 MF: C25H22ClNO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (RS) - alpha - Cyano - 3 - phenoxybenzyl (RS) - 2 - (4 - chlorophenyl) - 3 - methylbutyrate
  2. Agrofen
  3. Aqmatrine
  4. Belmark
  5. Cyano (3 - phenoxyphenyl) methyl 4 - chloro - alpha - (1 - methylethyl) benzeneacetate
  6. Ectrin
  7. Evercide 2362
  8. Fenkem
  9. Fenkill
  10. Fenval
  11. Fenvalerate
  12. Furitrothion
  13. Gold crest tribute
  14. Insectral
  15. OMS - 2000
  16. Phenvalerate
  1. Pydrin
  2. S 5602
  3. SD 43775
  4. Sanmarton
  5. Sumibac
  6. Sumicidin
  7. Sumicidin 20E
  8. Sumifleece
  9. Sumifly
  10. Sumipower
  11. Sumitick
  12. Tribute
  13. WL 43775
  14. alpha - Cyano - 3 - phenoxybenzyl 2 - (4 - chlorophenyl) isovalerate
  15. alpha - Cyano - 3 - phenoxybenzyl - 2 - (4 - chlorophenyl) - 3 - methylbutyrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis inhalation
hamster 		23.8 µmol/L MUREAV 608,28,2006
cytogenetic analysis hamster 23.8 µmol/L MUREAV 608,28,2006
cytogenetic analysis human lymphocyte 2 mg/L MUTAEX 4,72,1989
cytogenetic analysis intraperitoneal
mouse 		200 mg/kg MUREAV 222,149,1989
cytogenetic analysis oral
mouse 		200 mg/kg MUREAV 222,149,1989
cytogenetic analysis subcutaneous
mouse 		200 mg/kg MUREAV 222,149,1989
cytogenetic analysis intraperitoneal
mouse 		20 mg/kg/5 day MUREAV 520,125,2002
cytogenetic analysis oral
rat 		1,050 mg/kg/3 week- continuous MUREAV 105,101,1982
micronucleus test unreported route
mouse 		10 mg/kg CHYCDW 20,238,1986
micronucleus test intraperitoneal
mouse 		300 mg/kg/24 hour- intermittent MUREAV 222,149,1989
morphological transform oral
rat 		3,750 mg/kg/10 week- intermittent ARTODN 61,218,1988
other mutation test systems rabbit liver 2 mg/L JPFCD2 23,439,1988
other mutation test systems rabbit other cell types 200 µg/L JPFCD2 23,439,1988
sister chromatid exchange human lymphocyte 10 mg/L MUTAEX 4,72,1989
sister chromatid exchange intraperitoneal
mouse 		5 mg/kg MUREAV 520,125,2002
sperm morphology unreported route
mouse 		20 mg/kg CHYCDW 20,238,1986
sperm morphology parenteral
mouse 		100 mg/kg MUREAV 222,149,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg (18 day pregnant/1-5 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		NETEEC 21,611,1999
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg (18 day pregnant/5 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects 		NETEEC 27,609,2005
parenteral
mouse 		lowest published toxic dose: 100 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 222,149,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lowest published lethal dose: 200 µg/kg N/R TXAPA9 66,290,1982
inhalation
rat 		lethal concentration (50 percent kill): >2.9 gm/m3 N/R ENTOX* -,328,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): >500 mg/kg N/R JAFCAU 26,954,1978
intraspinal
mouse 		lowest published toxic dose: 4 µg/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve EJPHAZ 534,123,2006
intravenous
rat 		lowest published lethal dose: 50 mg/kg Behavioral: Tremor

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity 		ARTODN 45,325,1980
oral
wild bird 		lethal dose (50 percent kill): >1 gm/kg N/R ENTOX* -,328,2005
oral
chicken 		lowest published lethal dose: 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		IVEJAC 58,941,1981
oral
chicken 		lethal dose (50 percent kill): >1 gm/kg N/R ENTOX* -,328,2005
oral
dog 		lethal dose (50 percent kill): >1 gm/kg N/R SPEADM 78-1,6,1978
oral
domestic animal 		lethal dose (50 percent kill): >1,600 mg/kg N/R 85JFAN A207,1984
oral
mouse 		lethal dose (50 percent kill): 185 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		FAATDF 5,278,1985
oral
quail 		lethal dose (50 percent kill): >4 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Behavioral: Muscle contraction or spasticity 		JTEHD6 10,307,1982
oral
rat 		lethal dose (50 percent kill): 70,200 µg/kg Eye: Lacrimation

Behavioral: Excitement

Behavioral: Ataxia 		CHYCDW 21,215,1987
oral
rat 		lowest published toxic dose: 389 mg/kg Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		BECTA6 70,839,2003
oral
rat 		lowest published lethal dose: 1,949 mg/kg N/R BECTA6 70,839,2003
oral
rat 		lethal dose (50 percent kill): >400 mg/kg N/R ENTOX* -,328,2005
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,388,1991
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R ENTOX* -,328,2005
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 451 mg/kg Brain and Coverings: Recordings from specific areas of CNS GISAAA 53(4),70,1988
unreported route
rat 		lethal dose (50 percent kill): 202 mg/kg N/R IJEBA6 29,176,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 290 µg/m3/24 hour/13 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 53(4),70,1988
intraperitoneal
rat 		lowest published toxic dose: 700 mg/kg/7 day- intermittent Behavioral: Tremor TOLED5 89,29,1996
intraperitoneal
rat 		lowest published toxic dose: 2,400 mg/kg/12 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia TOLED5 89,29,1996
intraperitoneal
rat 		lowest published toxic dose: 1,700 mg/kg/17 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia TOLED5 89,29,1996
intraperitoneal
rat 		lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 89,29,1996
intraperitoneal
rat 		lowest published toxic dose: 4,500 mg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes TOLED5 89,29,1996
oral
chicken 		lowest published toxic dose: 14,717 mg/kg/28 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		IJEBA6 32,752,1994
oral
chicken 		lowest published toxic dose: 196 mg/kg/8 week- continuous Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		TOPADD 32,364,2004
oral
dog 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		FAATDF 4,577,1981
oral
mouse 		lowest published toxic dose: 109 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 3,114,1983
oral
quail 		lowest published toxic dose: 180 gm/kg/5 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTEHD6 10,307,1982
oral
quail 		lowest published toxic dose: 1,152 mg/kg/7 day- continuous Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		BECTA6 31,479,1983
oral
rat 		lowest published toxic dose: 36,400 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTEHD6 13,83,1984
oral
rat 		lowest published toxic dose: 2,002 mg/kg/13 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 8,175,1988
oral
rat 		lowest published toxic dose: 129.5 mg/kg/7 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		BECTA6 70,839,2003
oral
rat 		lowest published toxic dose: 388.5 mg/kg/21 day- intermittent Blood: Macrocytosis

Blood: Changes in leukocyte (WBC) count 		BECTA6 70,839,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 53,309,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 53,309,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 53,309,1991
TOXICOLOGY REVIEW
JTCTDW 38,103,2000
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,328,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
HUTOX* -,541,1996
TOXICOLOGY REVIEW
MUREAV 681,3,2009
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,182,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2212;
Number of Industries 8;
Total Number of Facilities 429;
Number of Occupations 9;
Total Number of Employees Exposed 4,830;
Total Number of Female Employees Exposed 1,319


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IVEJAC Indian Veterinary Journal. (Dr. R. Krishnamurti, G.M.V.C., 8 Avenue Rd., Madras 600 034, India) V.1- 1924-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us