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Registry of Toxic Effects of Chemical Substances (RTECS)

Benz(a)anthracene

RTECS #

CV9275000

CAS #

56-55-3

Updated

September 201

Molecular Weight

228.30

Molecular Formula

C18H12

Synonyms

1,2-Benz(a)anthracene
1,2-Benzanthracene
1,2-Benzanthrazen (German)
1,2-Benzanthrene
1,2-Benzoanthracene
2,3-Benzophenanthrene
2,3-Benzphenanthrene
Benzanthracene
Benzanthrene
Benzo(a)anthracene
Benzo(b)phenanthrene
Naphthanthracene
RCRA waste number U018
Tetraphene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/hamster1800 mg/kg/24HAMSHAR 27,199,1979
DNA adductlung/hamster1 mg/LCBINA8 4,389,1971/1972
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA adductlymphocyte/human30 µmol/LPNASA6 85,3513,1988
DNA adductlung/hamster3 µmol/LMUREAV 419,91,1998
DNA adducttestis/salmon5 µg/1H-continuousBIJOAK 110,159,1968
DNA adductintratracheal/rat75 mg/kgMUREAV 312,165,1994
DNA adductliver/rat3 µmol/LMUREAV 419,91,1998
DNA adductliver/mouse60 µmol/LJJIND8 62,947,1979
DNA adductother cell types/mouse1 mg/LCBINA8 4,389,1971/1972
DNA adductskin/mouse192 µmol/kgCRNGDP 5,231,1984
DNA Damagefibroblast/hamster5 mg/LBCPCA6 20,1297,1971
DNA Damagekidney/hamster5 mg/LBCPCA6 20,1297,1971
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
DNA Damagefibroblast/hamster10 µmol/L/2H (-enzymatic activation step)MUREAV 650,96,2008
DNA Damage/Escherichia coli78.6 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA inhibitionother cell types/hamster450 µmol/LCALEDQ 53,163,1990
DNA inhibitionother cell types/mouse10 µmol/LJJIND8 65,1321,1980
DNA inhibitionother cell types/human10 µmol/LCNREA8 42,3676,1982
DNA inhibition/Other microorganisms200 µg/LPNASA6 74,1378,1977
DNA repairoral/Drosophila melanogaster36 gm/LMUREAV 290,175,1993
host-mediated assaySalmonella typhimurium/mouse1600 mg/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/hamster1800 mg/kg/24HAMSHAR 27,199,1979
micronucleus testintratracheal/rat75 mg/kg/16H- intermittentMUREAV 326,147,1995
micronucleus testintraperitoneal/mouse500 mg/kgTJIDAH 101,259,1986
micronucleus testmultiple/non-mammalian species188 ppbMUREAV 292,83,1993
micronucleus testliver/human200 µmol/L/24HTXCYAC 198,315,2004
micronucleus testskin/mouse240 mg/kg/3DMUREAV 588,58,2005
morphological transformembryo/mouse0.5 mg/L/2DMUREAV 588,7,2005
morphological transformembryo/mouse1 mg/L/72HMUREAV 702,100,2010
morphological transformembryo/mouse1 mg/L/10DMUREAV 702,100,2010
morphological transformoral/rat180 mg/kgCNREA8 40,1157,1980
morphological transformembryo/rat3 mg/LJJIND8 67,1303,1981
morphological transformfibroblast/mouse4 mg/LJJIND8 67,1303,1981
morphological transformembryo/mouse12500 µg/LENMUDM 4,105,1982
morphological transformembryo/hamster6 mg/L/7D-continuousIJCNAW 9,435,1972
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
morphological transformlung/hamster100 µg/LTXCYAC 17,149,1980
mutation in mammalian somatic cellslymphocyte/human9 µmol/LDTESD7 10,277,1982
mutation in mammalian somatic cellslung/hamster1 mg/L/3HBJCAAI 39,540,1979
mutation in microorganisms/Salmonella typhimurium7.5 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium0.019 mg/L/48H (+enzymatic activation step)MUREAV 750,12,2013
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium7.5 µg/plate/48H (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium380.2 pmol/L (+enzymatic activation step)MUREAV 626,88,2007
mutation in microorganisms/Salmonella typhimurium4 µg/plate (-enzymatic activation step)CRNGDP 5,747,1984
mutation in microorganismslung/hamster109 µmol/L (+enzymatic activation step)MUREAV 46,27,1977
mutation in microorganismslymphocyte/mouse2 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
other mutation test systems/Salmonella typhimurium2400 µg/LMUREAV 192,239,1987
other mutation test systemsliver/rat1 µmol/L/48HMUREAV 615,87,2007
other mutation test systemslung/hamster1 mg/LCBINA8 4,389,1971/1972
phage inhibition capacity/Escherichia coli50 mg/LCNREA8 41,532,1981
sex chromosome loss and nondisjunctionparenteral/Drosophila melanogaster5 mmol/LEJGCA9 4,400,1975
sister chromatid exchangeintratracheal/rat150 mg/kgMUREAV 312,165,1994
sister chromatid exchangeliver/rat10 µmol/LMUREAV 91,467,1981
sister chromatid exchangeintraperitoneal/hamster900 mg/kg/24HMUREAV 66,65,1979
sister chromatid exchangeovary/hamster100 µmol/LCMMUAO 6,1,1980
sister chromatid exchangelung/hamster5 mg/LENMUDM 7,137,1985
specific locus testother cell types/human5 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009
specific locus testparenteral/Drosophila melanogaster5 mmol/LCNREA8 33,2354,1973
specific locus testoral/Drosophila melanogaster5 mmol/LMUREAV 234,71,1990
sperm morphologyoral/hamster900 mg/kg/24HAMSHAR 27,199,1979
Unscheduled DNA Synthesisliver/other fish200 nmol/LHKXUDL 4,368,1984
Unscheduled DNA Synthesisother cell types/other fish100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA Synthesisfibroblast/human100 µmol/LCBPCEE 86,399,1987
Unscheduled DNA SynthesisHeLa cell/human100 µmol/LCNREA8 38,2621,1978
Unscheduled DNA Synthesisliver/rat100 µmol/LENMUDM 3,11,1981

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 80 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
BJCAAI 22,825,1968
skin/mouse toxic dose: 18 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 38,1705,1978
skin/mouse toxic dose: 360 mg/kg/56W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CNREA8 11,892,1951
skin/mouse toxic dose: 240 mg/kg/1W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 9,177,1955
skin/mouse lowest published toxic dose: 18 mg/kgTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 38,1699,1978
subcutaneous/mouse lowest published toxic dose: 2 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 15,632,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/mouse lowest published lethal dose: 10 mg/kgJNCIAM 1,225,1940
intravenous/rat lethal dose (50 percent kill): >200 mg/kgMOPMA3 4,427,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 47943 µg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
TOXID9 78,397,2004
subcutaneous/rat lowest published toxic dose: 0.3 mg/kg/3D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTOLED5 180,212,2008
subcutaneous/rat lowest published toxic dose: 3 mg/kg/3D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Changes in uterine weight
TOLED5 180,212,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 3,45,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,135,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,135,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWENTOX* -,250,2005
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 543,17,2003
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 727,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code B0045; Number of Industries 4; Total Number of Facilities 149; Number of Occupations 4; Total Number of Employees Exposed 2311

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; In vitro UDS in rat liver
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse prostate
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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