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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzamide, N-(3-(1-methylethoxy)phenyl)-2-(trifluoromethyl)-

RTECS #

CV5581320

CAS #

66332-96-5; 84461-35-8

Updated

December 2012

Molecular Weight

323.34

Molecular Formula

C17H16F3NO2

Synonyms

alpha,alpha,alpha-Trifluoro-3'-isopropoxy-o-toluanelide
alpha,alpha,alpha-Trifluoro-3'-isopropoxy-o-toluanilide
Flutolanil
Moncut
N-(3-(1-Methylethoxy)phenyl)-2-(trifluoromethyl)benzamide
NNF-136

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 5.98 gm/m3/4HFEREAC 66,10817,2001
intraperitoneal/mouse lethal dose (50 percent kill): >10 gm/kgNNGADV 13,153,1988
intraperitoneal/rat lethal dose (50 percent kill): >10 gm/kgNNGADV 13,153,1988
oral/mammal (species unspecified) lethal dose (50 percent kill): 10 gm/kgFEREAC 66,10817,2001
oral/mouse lethal dose (50 percent kill): >10 gm/kgPEMNDP 9,426,1991
oral/rat lethal dose (50 percent kill): 10 gm/kgFMCHA2 -,C209,1991
skin/mammal (species unspecified) lethal dose (50 percent kill): 2 gm/kgFEREAC 66,10817,2001
skin/rat lethal dose (50 percent kill): >5 gm/kgJPIFAN (47),23,1985
subcutaneous/mouse lethal dose (50 percent kill): >10 gm/kgNNGADV 13,153,1988
subcutaneous/rat lethal dose (50 percent kill): >10 gm/kgNNGADV 13,153,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 913 gm/kg/2Y- intermittentGastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NNGADV 13,153,1988
oral/Dog lowest published toxic dose: 36000 mg/kg/90D- intermittentLiver: Other changesFEREAC 66,10817,2001
oral/Dog lowest published toxic dose: 36 gm/kg/90D- continuousLiver: Changes in liver weightHBPTO* 2,1197,2001
oral/Dog lowest published toxic dose: 182.5 gm/kg/2Y- continuousGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1197,2001
oral/rat lowest published toxic dose: 18 gm/kg/90D- continuousLiver: Changes in liver weightHBPTO* 2,1197,2001
oral/rat lowest published toxic dose: 26910 mg/kg/90D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 66,10817,2001
oral/rat lowest published toxic dose: 26910 mg/kg/90D- intermittentLiver: Changes in liver weightFEREAC 66,10817,2001
oral/rat lowest published toxic dose: 18 gm/kg/30D- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NNGADV 13,153,1988
oral/rat lowest published toxic dose: 438 gm/kg/2Y- continuousLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NNGADV 13,153,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFEREAC 73,33013,2008
TOXICOLOGY REVIEWFEREAC 75,864,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,371,1998
Occupational Exposure Limit-JAPANOccupational Exposure Limit 10 mg/m3, MAY2012

Status in Federal Agencies

OrganizationReference
On EPA IRIS database
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