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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzamide, 2,6-dichlorothio-

RTECS #

CV3850000

CAS #

1918-13-4

Updated

December 1997

Molecular Weight

206.09

Molecular Formula

C7H5Cl2NS

Synonyms

2,6-Dichlorobenzenecarbothioamide
2,6-Dichlorothiobenzamide
2,6-Dichlor-thiobenzamid (German)
Benzenecarbothioamide, 2,6-dichloro- (9CI)
Chlorothiamide
Chlorthiamid
Chlorthiamide
Chlorthioamide
Chlortiamid
DCBN
Prefix
SD 7961
WL-5792

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse500 mg/kgCYGEDX 14(6),38,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 242 mg/kgBehavioral: Somnolence (general depressed activity)ATXKA8 23,42,1967
oral/chicken lethal dose (50 percent kill): >1 gm/kgATXKA8 23,42,1967
oral/Dog lethal dose (50 percent kill): >1 gm/kgGastrointestinal: Nausea or vomitingATXKA8 23,42,1967
oral/domestic animal lowest published lethal dose: 125 mg/kgBehavioral: SleepATXKA8 23,42,1967
oral/mouse lethal dose (50 percent kill): 500 mg/kgBehavioral: SleepATXKA8 23,42,1967
oral/rabbit lethal dose (50 percent kill): 300 mg/kgBehavioral: Somnolence (general depressed activity)ATXKA8 23,42,1967
oral/rat lethal dose (50 percent kill): 757 mg/kgATXKA8 23,42,1967
skin/rat lethal dose (50 percent kill): >1 gm/kgBehavioral: General anestheticATXKA8 23,42,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 3150 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainATXKA8 23,42,1967
oral/rat lowest published toxic dose: 16800 mg/kg/4W- continuousLiver: Changes in liver weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ATXKA8 23,42,1967
oral/rat lowest published toxic dose: 173 mg/kg/13W- continuousLiver: Changes in liver weightATXKA8 23,42,1967

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
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