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Registry of Toxic Effects of Chemical Substances (RTECS)

Benzaldehyde

RTECS #

CU4375000

CAS #

100-52-7

Updated

July 2013

Molecular Weight

106.13

Molecular Formula

C7H6O

Synonyms

Almond artificial essential oil
Artificial almond oil
Artificial essential oil of almond
Benzaldehyde FFC
Benzene carbaldehyde
Benzenecarbonal
Benzoic aldehyde
NCI-C56133
Phenylmethanal

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 14,693,1976

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1 gm/LESKHA5 (103),64,1985
Cytogenetic Analysisovary/hamster50 nmol/L/24HHPV137 -,-,2003
Cytogenetic Analysisovary/hamster1000 mg/L (-enzymatic activation step)HPV137 -,-,2003
Cytogenetic Analysisovary/hamster50 nmol/L/24H (+enzymatic activation step)HPV141 -,-,2001
DNA Damagelymphocyte/human10 mmol/LFCTOD7 48,1239,2010
mutation in mammalian somatic cellslymphocyte/mouse400 mg/LNTPTR* NTP-TR-378,1990
mutation in microorganismsother cell types/mouse400 µg/L (-enzymatic activation step)HPV141 -,-,2001
mutation in microorganisms/Saccharomyes cerevisiae1313 mg/L/16HMUTAEX 20,105,2004
other mutation test systemsoral/Drosophila melanogaster1 mmol/LFCTOD7 46,1034,2008
sister chromatid exchangelymphocyte/human2 mmol/L/88HHPV137 -,-,2003
sister chromatid exchangeovary/hamster50 mg/LEMMUEG 10(Suppl 10),1,1987
sister chromatid exchangelymphocyte/human1 mmol/LMUREAV 206,17,1988
sister chromatid exchangelymphocyte/human2 mmol/L/88H (+enzymatic activation step)HPV141 -,-,2001
specific locus testlymphocyte/mouse400 mg/LEMMUEG 17,196,1991

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 154 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-378,1990
oral/mouse lowest published toxic dose: 206000 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-253782/AS
oral/mouse lowest published toxic dose: 154500 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-253782/AS
oral/mouse lowest published toxic dose: 432600 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV137 -,-,2003
oral/mouse lowest published toxic dose: 154500 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV141 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 1047 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
inhalation/human lowest published toxic concentration: 0.15 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,396,1984
inhalation/mouse Lethal concentration: >500 mg/m3Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
GTPZAB 18(11),40,1974
inhalation/rat Lethal concentration: >500 mg/m3Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
GTPZAB 18(11),40,1974
intraperitoneal/mouse lethal dose (50 percent kill): 9 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,99,1976
intraperitoneal/mouse lethal dose (50 percent kill): 3265 mg/kgHPV141 -,-,2001
oral/guinea pig lethal dose (50 percent kill): 1000 mg/kgHPV141 -,-,2001
oral/guinea pig lethal dose (50 percent kill): 1000 mg/kgBehavioral: Tremor

Gastrointestinal: Ulceration or bleeding from small intestine

Kidney, Ureter, and Bladder: Urine volume increased
HPV137 -,-,2003
oral/human lowest published lethal dose: 714.3 mg/kgVCVGK* -,396,1984
oral/mammal (species unspecified) lethal dose (50 percent kill): 2020 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 2020 mg/kgVCVGK* -,396,1984
oral/mouse lethal dose (50 percent kill): 28 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes
EJTXAZ 9,99,1976
oral/rat lethal dose (50 percent kill): 1300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma
FCTXAV 2,327,1964
oral/rat lethal dose (50 percent kill): 1300 mg/kgBehavioral: ComaHPV137 -,-,2003
oral/rat lethal dose (50 percent kill): 1300 mg/kgHPV141 -,-,2001
skin/rabbit lethal dose (50 percent kill): >1.25 gm/kgHPV141 -,-,2001
subcutaneous/rabbit lethal dose (50 percent kill): 5 gm/kgFCTXAV 14,693,1976
subcutaneous/rat lowest published lethal dose: 5 gm/kgLung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
AIPTAK 27,163,1922

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/6H/14D- continuousLiver: Changes in liver weight

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AIHAAP 52,503,1991
inhalation/rat lowest published toxic concentration: 26 mg/m3/5H/17W- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 18(11),40,1974
inhalation/rat lowest published toxic concentration: 500 ppm/14D- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
HPV137 -,-,2003
inhalation/rat lowest published toxic concentration: 750 ppm/14D- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV137 -,-,2003
inhalation/rat lowest published toxic concentration: 500 ppm/14D- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
HPV141 -,-,2001
inhalation/rat lowest published toxic concentration: 1000 ppm/14D- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 8000 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV141 -,-,2001
oral/mouse lowest published toxic dose: 39000 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV141 -,-,2001
oral/mouse lowest published toxic dose: 78000 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 9600 mg/kg/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-378,1990
oral/rat lowest published toxic dose: 52 gm/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NTPTR* NTP-TR-378,1990
oral/rat lowest published toxic dose: 8000 mg/kg/16D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 52000 mg/kg/13W- intermittentBrain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV141 -,-,2001
oral/rat lowest published toxic dose: 208000 mg/kg/104W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV141 -,-,2001
oral/rat lowest published toxic dose: 78 gm/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-378,1990
oral/rat lowest published toxic dose: 600 mg/kg/5W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Multiple effects
VCVGK* -,396,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,237,1998
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (4.4 mg/m3), ceiling concentration 4 ppm (17.4 mg/m3), NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, SEP2000
Occupational Exposure Limit-POLANDtime-weighted average 10 mg/m3, short term exposure limit 40 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84494; Number of Industries 31; Total Number of Facilities 3776; Number of Occupations 58; Total Number of Employees Exposed 67721; Total Number of Female Employees Exposed 27021
National Occupational Hazard Survey 1974Hazard Code 84494; Number of Industries 18; Total Number of Facilities 1409; Number of Occupations 43; Total Number of Employees Exposed 15976

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis Studies (gavage);some evidence:mouse NTPTR* NTP-TR-378,1990
On EPA IRIS database
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