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Registry of Toxic Effects of Chemical Substances (RTECS)

Benz(e)acephenanthrylene

RTECS #

CU1400000

CAS #

205-99-2

Updated

September 201

Molecular Weight

252.32

Molecular Formula

C20H12

Synonyms

2,3-Benzfluoranthene
2,3-Benzofluoranthene
2,3-Benzofluoranthrene
3,4-Benz(e)acephenanthrylene
3,4-Benzfluoranthene
3,4-Benzofluoranthene
B(b)F
Benzo(b)fluoranthene
Benzo(b)fluoranthene (ACGIH)
Benzo(e)fluoranthene

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductlung/hamster3 µmol/LMUREAV 419,91,1998
DNA adductintraperitoneal/rat100 mg/kgCRNGDP 13,1731,1992
DNA adductliver/rat3 µmol/LMUREAV 419,91,1998
DNA adductoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
DNA adductliver/rat3 µmol/L/24HMUTAEX 22,55,2007
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
DNA Damage/Escherichia coli414.5 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
micronucleus testoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995
micronucleus testliver/human100 µmol/L/24HTXCYAC 198,315,2004
micronucleus testintraperitoneal/rat100 mg/kgEMMUEG 17(Suppl 19),13,1991
morphological transformlung/hamster100 µg/LTXCYAC 17,149,1980
mutation in mammalian somatic cellslymphocyte/human55 µg/LMUREAV 371,123,1996
mutation in microorganisms/Salmonella typhimurium31 nmol/plate (-enzymatic activation step)CRNGDP 6,1023,1985
mutation in microorganisms/Salmonella typhimurium68 nmol/plate/48H (+enzymatic activation step)MUREAV 557,99,2004
other mutation test systemsliver/rat100 nmol/L/48HMUREAV 615,87,2007
sister chromatid exchangeintraperitoneal/hamster900 mg/kg/24HMUREAV 66,65,1979
sister chromatid exchangeintraperitoneal/rat100 mg/kgEMMUEG 17(Suppl 19),13,1991
Unscheduled DNA Synthesisoral/mouse6.3 mg/kg/9W- intermittentJJATDK 15,59,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 5 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JJIND8 71,539,1983
implant/rat toxic dose: 5 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
50NNAZ 7,571,1983
intraperitoneal/mouse lowest published toxic dose: 5046 µg/kg/15D- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
CALEDQ 34,15,1987
skin/mouse lowest published toxic dose: 88 ng/kg/120W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
ARGEAR 50,266,1980
skin/mouse toxic dose: 4037 µg/kg/20D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CRNGDP 6,1023,1985
skin/mouse toxic dose: 72 mg/kg/60W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CANCAR 12,1194,1959
subcutaneous/mouse lowest published toxic dose: 72 mg/kg/9W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
AICCA6 19,490,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 7570 µg/kgLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 78,397,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 52987 µg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,397,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 3,69,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,147,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,147,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWMUREAV 636,144,2007
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-NORWAYtime-weighted average 0.04 mg/m3, JAN1999

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0466; Number of Industries 3; Total Number of Facilities 142; Number of Occupations 3; Total Number of Employees Exposed 2283

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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