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Benz (e) acephenanthrylene

RTECS #: CU1400000

CAS #: 205-99-2


UPDATE: August 2008 MW: 252.32 MF: C20H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,3 - Benzfluoranthene
  2. 2,3 - Benzofluoranthene
  3. 2,3 - Benzofluoranthrene
  4. 3,4 - Benz (e) acephenanthrylene
  5. 3,4 - Benzfluoranthene
  1. 3,4 - Benzofluoranthene
  2. B (b) F
  3. Benzo (b) fluoranthene
  4. Benzo (b) fluoranthene (ACGIH)
  5. Benzo (e) fluoranthene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct hamster lung 3 mol/L MUREAV 419,91,1998
DNA adduct oral
mouse
6.3 mg/kg/9 week- intermittent JJATDK 15,59,1995
DNA adduct intraperitoneal
rat
100 mg/kg CRNGDP 13,1731,1992
DNA adduct rat liver 3 mol/L MUREAV 419,91,1998
DNA adduct rat liver 30 mol/L/24 hour MUTAEX 22,55,2007
DNA damage Escherichia coli 414.5 g/L/3 hour (+enzymatic activation step) MUREAV 515,85,2002
DNA damage human fibroblast 1 mol/L/24 hour MUREAV 547,109,2004
unscheduled DNA synthesis oral
mouse
6.3 mg/kg/9 week- intermittent JJATDK 15,59,1995
mutation in microorganisms Salmonella typhimurium 31 nmol/plate (-enzymatic activation step) CRNGDP 6,1023,1985
mutation in microorganisms Salmonella typhimurium 68 nmol/plate/48 hour (+enzymatic activation step) MUREAV 557,99,2004
micronucleus test human liver 100 mol/L/24 hour TXCYAC 198,315,2004
micronucleus test oral
mouse
6.3 mg/kg/9 week- intermittent JJATDK 15,59,1995
micronucleus test intraperitoneal
rat
100 mg/kg EMMUEG 17(Suppl 19),13,1991
mutation in mammalian somatic cells human lymphocyte 55 g/L MUREAV 371,123,1996
morphological transform hamster lung 100 g/L TXCYAC 17,149,1980
other mutation test systems rat liver 100 nmol/L/48 hour MUREAV 615,87,2007
sister chromatid exchange intraperitoneal
hamster
900 mg/kg/24 hour MUREAV 66,65,1979
sister chromatid exchange intraperitoneal
rat
100 mg/kg EMMUEG 17(Suppl 19),13,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JJIND8 71,539,1983
implant
rat
toxic dose : 5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
50NNAZ 7,571,1983
intraperitoneal
mouse
lowest published toxic dose: 5,046 g/kg/15 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
CALEDQ 34,15,1987
subcutaneous
mouse
lowest published toxic dose: 72 mg/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
AICCA6 19,490,1963
skin
mouse
lowest published toxic dose: 88 ng/kg/120 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
ARGEAR 50,266,1980
skin
mouse
toxic dose : 72 mg/kg/60 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CANCAR 12,1194,1959
skin
mouse
toxic dose : 4,037 g/kg/20 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CRNGDP 6,1023,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 7,570 g/kg Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TOXID9 78,397,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 52,987 g/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,397,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Control as low as possible DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 3,69,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 32,147,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 32,147,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
MUREAV 544,397,2003
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 540,89,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
MUREAV 613,103,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - NORWAY time-weighted average 0.04 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0466;
Number of Industries 3;
Total Number of Facilities 142;
Number of Occupations 3;
Total Number of Employees Exposed 2,283


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

50NNAZ "Polynuclear Aromatic Hydrocarbons, International Symposium, 7th, 1982," Cooke, M., and A.J. Dennis, eds., Columbus, OH, Battelle Press, 1983
AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW.
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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