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Registry of Toxic Effects of Chemical Substances (RTECS)

Bentonite

RTECS #

CT9450000

CAS #

1302-78-9; 11004-12-9

Updated

December 2012

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

Albagel Premium USP 4444
Bentonite 2073
Bentonite magma
HI-Jel
Imvite I.G.B.A
Magbond
Montmorillonite
Panther creek bentonite
Southern bentonite
Tixoton
Volcaly bentonite BC
Volclay
Wilkinite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/human120 mg/L/24HMUREAV 720,62,2011
DNA Damageother cell types/human60 mg/L/48HMUREAV 720,62,2011
DNA Damageother cell types/human30 mg/L/72HMUREAV 720,62,2011
micronucleus testother cell types/human60 mg/L/24HMUREAV 720,62,2011
micronucleus testother cell types/human30 mg/L/72HMUREAV 720,62,2011

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 12000 gm/kg/28W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ANYAA9 57,678,1954

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published toxic dose: 240 mg/kg/1HLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
IVIEM* -,453,1985
intravenous/Dog lowest published lethal dose: 10 mg/kgVascular: Thromobosis distant from injection siteJCINAO 42,860,1963
intravenous/rat lethal dose (50 percent kill): 35 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaBSIBAC 44,1685,1968
subcutaneous/mouse lowest published toxic dose: 15.96 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJPETAB 329,439,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 14 gm/kg/7D- intermittentBehavioral: Change in motor activity (specific assay)EJPHAZ 551,156,2006
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentEndocrine: Other changesEJPHAZ 551,156,2006

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg/m3 (resp. dust), 2 mg/m3 (total dust), MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1608; Number of Industries 3; Total Number of Facilities 70; Number of Occupations 3; Total Number of Employees Exposed 1732
National Occupational Exposure Survey 1983Hazard Code X9436; Number of Industries 2; Total Number of Facilities 171; Number of Occupations 4; Total Number of Employees Exposed 6525
National Occupational Exposure Survey 1983Hazard Code X9494; Number of Industries 4; Total Number of Facilities 115; Number of Occupations 3; Total Number of Employees Exposed 11850; Total Number of Female Employees Exposed 11045
National Occupational Exposure Survey 1983Hazard Code 90340; Number of Industries 212; Total Number of Facilities 31430; Number of Occupations 147; Total Number of Employees Exposed 545795; Total Number of Female Employees Exposed 36750
National Occupational Hazard Survey 1974Hazard Code 90340; Number of Industries 169; Total Number of Facilities 22741; Number of Occupations 130; Total Number of Employees Exposed 286502

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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