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Bentonite

RTECS #: CT9450000

CAS #: 1302-78-9


UPDATE: May 2008 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Albagel Premium USP 4444
  2. Bentonite 2073
  3. Bentonite magma
  4. HI - Jel
  5. Imvite I.G.B.A
  6. Magbond
  7. Montmorillonite
  1. Panther creek bentonite
  2. Southern bentonite
  3. Tixoton
  4. Volcaly bentonite BC
  5. Volclay
  6. Wilkinite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 12,000 gm/kg/28 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ANYAA9 57,678,1954


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rat
lowest published toxic dose: 240 mg/kg/1 hour Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
IVIEM* -,453,1985
intravenous
dog
lowest published lethal dose: 10 mg/kg Vascular: Thromobosis distant from injection site JCINAO 42,860,1963
intravenous
rat
lethal dose (50 percent kill): 35 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema BSIBAC 44,1685,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 14 gm/kg/7 day- intermittent Behavioral: Change in motor activity (specific assay) EJPHAZ 551,156,2006
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- intermittent Endocrine: Other changes EJPHAZ 551,156,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg/m3 (respirable), 2 mg/m3 (total), APR2007


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 90340;
Number of Industries 169;
Total Number of Facilities 22,741;
Number of Occupations 130;
Total Number of Employees Exposed 286,502
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1608;
Number of Industries 3;
Total Number of Facilities 70;
Number of Occupations 3;
Total Number of Employees Exposed 1,732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9436;
Number of Industries 2;
Total Number of Facilities 171;
Number of Occupations 4;
Total Number of Employees Exposed 6,525
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9494;
Number of Industries 4;
Total Number of Facilities 115;
Number of Occupations 3;
Total Number of Employees Exposed 11,850;
Total Number of Female Employees Exposed 11,045
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 90340;
Number of Industries 212;
Total Number of Facilities 31,430;
Number of Occupations 147;
Total Number of Employees Exposed 545,795;
Total Number of Female Employees Exposed 36,750


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a mineral, natural or synthetic fiber
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
IVIEM* In Vitro Effects of Mineral Dusts (Third International Workshop, E. G. Beck, J. Bignon, Editors; Berlin, Springer-Verlag) 1985.
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-

Used as a mineral, natural or synthetic fiber

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen

ALT CAS #: 11004-12-9
Click Here for Additional Information about RTECS

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