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Registry of Toxic Effects of Chemical Substances (RTECS)

Barium chloride, dihydrate

RTECS #

CQ8751000

CAS #

10326-27-9

Updated

September 201

Molecular Weight

244.28

Molecular Formula

BaCl2·2H2O

Synonyms

Barium dichloride dihydrate
NCI-C61074

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformfibroblast/mouse300 mg/L/10DMUREAV 702,100,2010
specific locus testinhalation/mouse4094 µmol/LMUREAV 608,29,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 51 mg/kgTXAPA9 63,461,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 47 gm/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 19,527,1992
oral/mouse lowest published toxic dose: 1868 mg/kg/15D- continuousLiver: Changes in liver weightNTPTR* NTP-TR-432,1994
oral/mouse lowest published toxic dose: 1050 mg/kg/15D- intermittentLiver: Changes in liver weightHBTME* -,407,2007
oral/mouse lowest published toxic dose: 40950 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBTME* -,407,2007
oral/rat lowest published toxic dose: 16 gm/kg/13W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P
FAATDF 19,527,1992
oral/rat lowest published toxic dose: 5915 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightHBTME* -,407,2007
oral/rat lowest published toxic dose: 16380 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBTME* -,407,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 mg(Ba)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Ba)/m3DTLVS* 3,21,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Ba)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Ba)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Ba)/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.5 mg(Ba)/m3, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(Ba)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg(Ba)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Ba)/m3, KZG-week 1 mg(Ba)/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Ba)/m3, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7401; Number of Industries 3; Total Number of Facilities 42; Number of Occupations 3; Total Number of Employees Exposed 320

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);no evidence:mouse,rat
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