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Barium chloride, dihydrate

RTECS #: CQ8751000

CAS #: 10326-27-9


UPDATE: May 2009 MW: 244.28 MF: BaCl2•2H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Barium dichloride dihydrate
  1. NCI - C61074


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
specific locus test inhalation
mouse
4,094 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 51 mg/kg N/R TXAPA9 63,461,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 47 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 19,527,1992
oral
mouse
lowest published toxic dose: 1,868 mg/kg/15 day- continuous Liver: Changes in liver weight NTPTR* NTP-TR-432,1994
oral
mouse
lowest published toxic dose: 1,050 mg/kg/15 day- intermittent Liver: Changes in liver weight HBTME* -,407,2007
oral
mouse
lowest published toxic dose: 40,950 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBTME* -,407,2007
oral
rat
lowest published toxic dose: 16 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P
FAATDF 19,527,1992
oral
rat
lowest published toxic dose: 5,915 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight HBTME* -,407,2007
oral
rat
lowest published toxic dose: 16,380 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBTME* -,407,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Ba)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Ba)/m3 DTLVS* 3,21,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Ba)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Ba)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Ba)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.5 mg(Ba)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg(Ba)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Ba)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Ba)/m3;
KZG- week 1 mg(Ba)/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Ba)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7401;
Number of Industries 3;
Total Number of Facilities 42;
Number of Occupations 3;
Total Number of Employees Exposed 320


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
HBTME*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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