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Barium carbonate (1:1)

RTECS #: CQ8600000

CAS #: 513-77-9

UPDATE: May 2009 MW: 197.35 MF: CO3•Ba


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. BF 1 (salt)
  2. BW - C3
  3. BW - P
  4. Barium carbonate
  5. Barium monocarbonate
  1. C.I. 77099
  2. C.I. Pigment White 10
  3. Carbonic acid, barium salt (1:1)
  4. Pigment White 10


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,150 µg/m3/24 hour (16 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		GTPZAB 20(7),33,1976
inhalation
rat 		lowest published toxic concentration: 3,130 µg/m3/24 hour (16 week prior to copulation) Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes 		GTPZAB 20(7),33,1976
inhalation
rat 		lowest published toxic concentration: 5.2 mg/m3 (70 day male) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		VCVN1* -,139,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R 85GMAT -,23,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
intraperitoneal
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
intratracheal
rat 		lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial) 		VCVN1* -,137,1988
intravenous
rat 		lowest published lethal dose: 20 mg/kg N/R EQSSDX 1,1,1975
oral
cat 		lowest published lethal dose: 4 mg/kg N/R YKYUA6 28,329,1977
oral
chicken 		lowest published lethal dose: 623 mg/kg N/R HBTME* -,407,2007
oral
dog 		lowest published lethal dose: 400 mg/kg N/R PCOC** -,95,1966
oral
guinea pig 		lowest published lethal dose: 104 mg/kg N/R HBTME* -,407,2007
oral
human 		lowest published toxic dose: 11 mg/kg Gastrointestinal: Ulceration or bleeding from stomach YKYUA6 31,1247,1980
oral
human 		lowest published lethal dose: 17 mg/kg N/R YKYUA6 28,329,1977
oral
human 		lowest published toxic dose: 29 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Paresthesia

Behavioral: Muscle weakness 		IJMDAI 3,565,1967
oral
man 		lowest published lethal dose: 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Change in rate

Cardiac: Other changes 		YKYUA6 28,329,1977
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R 85GMAT -,23,1982
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
oral
mouse 		lowest published lethal dose: 200 mg/kg N/R HBTME* -,407,2007
oral
rat 		lethal dose (50 percent kill): 418 mg/kg N/R 85GMAT -,23,1982
oral
rat 		lethal dose (50 percent kill): 418 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany 		VCVN1* -,136,1988
oral
rat 		lowest published lethal dose: 1,480 mg/kg N/R HBTME* -,407,2007
oral
rabbit 		lowest published lethal dose: 418 mg/kg N/R HBTME* -,407,2007
oral
woman 		lowest published toxic dose: 800 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Other changes 		BMJOAE 289,882,1984
subcutaneous
rabbit 		lowest published toxic dose: 10 mg/kg Behavioral: Muscle contraction or spasticity

Vascular: Shock

Gastrointestinal: Nausea or vomiting 		HBPTO* 2,1358,2001
unreported route
human 		lowest published toxic dose: 2.86 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tetany

Gastrointestinal: Gastritis 		VCVN1* -,138,1988
unreported route
human 		lowest published lethal dose: 286 mg/kg N/R VCVN1* -,138,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 5 mg/m3/4 hour/16 week- intermittent Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN1* -,138,1988
inhalation
rat 		lowest published toxic concentration: 5,200 µg/m3/17 week- intermittent Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Changes in: P 		GISAAA 39(1),27,1974
inhalation
rat 		lowest published toxic concentration: 5.2 mg/m3/70 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		VCVN1* -,139,1988
inhalation
rat 		lowest published toxic concentration: 13.4 mg/m3/16 week- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes 		VCVN1* -,139,1988
intratracheal
rat 		lowest published toxic dose: 750 mg/kg/13 week- intermittent Behavioral: Change in motor activity (specific assay) GTPZAB 26(9),10,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Ba)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Ba)/m3 DTLVS* 3,21,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Ba)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Ba)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Ba)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Ba)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.5 mg(Ba)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Ba)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Ba)/m3;
KZG- week 1 mg(Ba)/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Ba)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 08640;
Number of Industries 28;
Total Number of Facilities 993;
Number of Occupations 38;
Total Number of Employees Exposed 14,843
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 08640;
Number of Industries 97;
Total Number of Facilities 5,689;
Number of Occupations 61;
Total Number of Employees Exposed 88,778;
Total Number of Female Employees Exposed 13,598


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTME*
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a rat poison

NIOSH PROFILE (BARIUM and ITS COMPOUNDS), SRI, 2/77

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   Reproductive Effector
   Human Data

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