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Registry of Toxic Effects of Chemical Substances (RTECS)

Barium carbonate (1:1)

RTECS #

CQ8600000

CAS #

513-77-9

Updated

April 2012

Molecular Weight

197.35

Molecular Formula

CO3·Ba

Synonyms

Barium carbonate
Barium monocarbonate
BF 1 (salt)
BW-C3
BW-P
C.I. 77099
C.I. Pigment White 10
Carbonic acid, barium salt (1:1)
Pigment White 10

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1150 µg/m3/24H (16W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
GTPZAB 20(7),33,1976
inhalation/rat 3130 µg/m3/24H (16W prior to copulation)Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
GTPZAB 20(7),33,1976
inhalation/rat 5.2 mg/m3 (70D male)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
VCVN1* -,139,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kg85GMAT -,23,1982
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVN1* -,136,1988
intraperitoneal/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVN1* -,136,1988
intratracheal/rat lowest published lethal dose: 250 mg/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)
VCVN1* -,137,1988
intravenous/rat lowest published lethal dose: 20 mg/kgEQSSDX 1,1,1975
oral/cat lowest published lethal dose: 4 mg/kgYKYUA6 28,329,1977
oral/chicken lowest published lethal dose: 623 mg/kgHBTME* -,407,2007
oral/Dog lowest published lethal dose: 400 mg/kgPCOC** -,95,1966
oral/guinea pig lowest published lethal dose: 104 mg/kgHBTME* -,407,2007
oral/human lowest published toxic dose: 11 mg/kgGastrointestinal: Ulceration or bleeding from stomachYKYUA6 31,1247,1980
oral/human lowest published lethal dose: 17 mg/kgYKYUA6 28,329,1977
oral/human lowest published toxic dose: 29 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Paresthesia

Behavioral: Muscle weakness
IJMDAI 3,565,1967
oral/man lowest published lethal dose: 800 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Change in rate

Cardiac: Other changes
YKYUA6 28,329,1977
oral/mouse lethal dose (50 percent kill): 200 mg/kg85GMAT -,23,1982
oral/mouse lowest published lethal dose: 200 mg/kgHBTME* -,407,2007
oral/mouse lethal dose (50 percent kill): 200 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVN1* -,136,1988
oral/rabbit lowest published lethal dose: 418 mg/kgHBTME* -,407,2007
oral/rat lethal dose (50 percent kill): 418 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVN1* -,136,1988
oral/rat lowest published lethal dose: 1480 mg/kgHBTME* -,407,2007
oral/rat lethal dose (50 percent kill): 418 mg/kg85GMAT -,23,1982
oral/woman lowest published toxic dose: 800 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Lung, Thorax, or Respiration: Other changes
BMJOAE 289,882,1984
subcutaneous/rabbit lowest published toxic dose: 10 mg/kgBehavioral: Muscle contraction or spasticity

Vascular: Shock

Gastrointestinal: Nausea or vomiting
HBPTO* 2,1358,2001
unreported route/human lowest published toxic dose: 2.86 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tetany

Gastrointestinal: Gastritis
VCVN1* -,138,1988
unreported route/human lowest published lethal dose: 286 mg/kgVCVN1* -,138,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 5 mg/m3/4H/16W- intermittentCardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,138,1988
inhalation/rat lowest published toxic concentration: 5.2 mg/m3/70D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,139,1988
inhalation/rat lowest published toxic concentration: 13.4 mg/m3/16W- intermittentEndocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes
VCVN1* -,139,1988
inhalation/rat lowest published toxic concentration: 5200 µg/m3/17W- intermittentVascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Changes in: P
GISAAA 39(1),27,1974
intratracheal/rat lowest published toxic dose: 750 mg/kg/13W- intermittentBehavioral: Change in motor activity (specific assay)GTPZAB 26(9),10,1982

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Ba)/m3DTLVS* 3,21,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Ba)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Ba)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Ba)/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(Ba)/m3, NOV2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.5 mg(Ba)/m3, short term exposure limit 2 mg(Ba)/m3, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg(Ba)/m3, MAC(short term exposure limit) 1.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(Ba)/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Ba)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 08640; Number of Industries 97; Total Number of Facilities 5689; Number of Occupations 61; Total Number of Employees Exposed 88778; Total Number of Female Employees Exposed 13598
National Occupational Hazard Survey 1974Hazard Code 08640; Number of Industries 28; Total Number of Facilities 993; Number of Occupations 38; Total Number of Employees Exposed 14843

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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