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Registry of Toxic Effects of Chemical Substances (RTECS)

Aspartic acid, L-

RTECS #

CI9098500

CAS #

56-84-8; 6899-03-2; 181119-33-5

Updated

December 2010

Molecular Weight

133.12

Molecular Formula

C4H7NO4

Synonyms

(+)-Aspartic acid
(L)-Aspartic acid
(S)-Aminobutanedioic acid
(S)-Aspartic acid
Asparagic acid
Asparaginic acid
ASPARAGINSAEURE (German)
Aspartic acid
Butanedioic acid, amino-, (S)-
H-Asp-OH
L-(+)-Aspartic acid
L-Aminosuccinic acid
L-Asparagic acid
L-Asparaginic acid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human10 mg/LMUREAV 372,75,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 6 gm/kgPCJOAU 25,569,1991
intraperitoneal/rat lowest published toxic dose: 500 mg/kgBehavioral: Change in motor activity (specific assay)FATOAO 53,22,1990
intraperitoneal/rat lowest published toxic dose: 100 mg/kgBehavioral: Alteration of classical conditioningFATOAO 53,22,1990
intraperitoneal/rat lowest published toxic dose: 10 mg/kgBehavioral: Alteration of operant conditioningFATOAO 53,22,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 100 mg/kg/10D- intermittentBehavioral: Alteration of classical conditioningFATOAO 53,22,1990
intraperitoneal/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentBehavioral: Excitement

Behavioral: Alteration of classical conditioning
FATOAO 53,22,1990
oral/rat lowest published toxic dose: 3000 mg/kg/60D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
SIMEJ* 48,1033,2007
oral/rat lowest published toxic dose: 64368 mg/kg/90D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 13231.8 mg/kg/90D- continuousGastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 2421 mg/kg/90D- continuousBiochemical: Metabolism (intermediary): Lipids including transportFCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 62694 mg/kg/90D- continuousKidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 127494 mg/kg/90D- continuousGastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes
FCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 249318 mg/kg/90D- continuousGastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 46,2789,2008
oral/rat lowest published toxic dose: 25079 mg/kg/7D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ARZNAD 32,738,1982

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWNBREV* 3,179,1979
TOXICOLOGY REVIEWNBREV* 9,299,1985

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81861; Number of Industries 3; Total Number of Facilities 634; Number of Occupations 11; Total Number of Employees Exposed 9033; Total Number of Female Employees Exposed 6545
National Occupational Hazard Survey 1974Hazard Code 81861; Number of Industries 3; Total Number of Facilities 803; Number of Occupations 3; Total Number of Employees Exposed 5939

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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