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L - Ascorbic acid

RTECS #: CI7650000

CAS #: 50-81-7


UPDATE: May 2009 MW: 176.14 MF: C6H8O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 3 - Keto - L - gulofuranolactone
  2. 3 - Oxo - L - gulofuranolactone
  3. 3 - Oxo - L - gulofuranolactone (enol form)
  4. Adenex
  5. Allercorb
  6. Antiscorbic vitamin
  7. Antiscorbutic vitamin
  8. Arco - cee
  9. Ascoltin
  10. Ascor - B.I.D.
  11. Ascorbajen
  12. Ascorbate
  13. Ascorbic acid
  14. Ascorbutina
  15. Ascorin
  16. Ascorteal
  17. Ascorvit
  18. C - Level
  19. C - Long
  20. C - Quin
  21. C - Span
  22. C - Vimin
  23. CE - VI - Sol
  24. Cantan
  25. Cantaxin
  26. Catavin C
  27. Ce - Mi - Lin
  28. Cebicure
  29. Cebid
  30. Cebion
  31. Cebione
  32. Cecon
  33. Cee - caps TD
  34. Cee - vite
  35. Cegiolan
  36. Ceglion
  37. Celaskon
  38. Celin
  39. Cemagyl
  40. Cemill
  41. Cenetone
  42. Cereon
  43. Cergona
  44. Cescorbat
  45. Cetamid
  46. Cetane - caps TD
  47. Cetemican
  48. Cevalin
  49. Cevatine
  50. Cevex
  51. Cevi - bid
  52. Cevimin
  1. Cevital
  2. Cevitamic acid
  3. Cevitamin
  4. Cevitan
  5. Cevitex
  6. Cewin
  7. Ciamin
  8. Cipca
  9. Citriscorb
  10. Colascor
  11. Concemin
  12. Davitamon C
  13. Dora - C - 500
  14. Duoscorb
  15. Hicee
  16. Hybrin
  17. IDO - C
  18. Kyselina askorbova (Czech)
  19. L (+) - Ascorbic acid
  20. L - 3 - Ketothreohexuronic acid lactone
  21. L - Ascorbate
  22. L - Lyxoascorbic acid
  23. L - Xyloascorbic acid
  24. L - threo - Hex - 2 - enonic acid, gamma - lactone
  25. Laroscorbine
  26. Lemascorb
  27. Liqui - Cee
  28. NCI - C54808
  29. NSC 33832
  30. Planavit C
  31. Proscorbin
  32. Redoxon
  33. Ribena
  34. Roscorbic
  35. Scorbacid
  36. Scorbu - C
  37. Secorbate
  38. Testascorbic
  39. Vicelat
  40. Vicomin C
  41. Viforcit
  42. Viscorin
  43. Vitace
  44. Vitacee
  45. Vitacimin
  46. Vitacin
  47. Vitamin C
  48. Vitamisin
  49. Vitascorbol
  50. Xitix
  51. ce lent


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 300 mg/L FCTXAV 18,497,1980
cytogenetic analysis intraperitoneal
mouse
1,600 mg/kg TCMUD8 9,51,1989
DNA damage Bacillus subtilis 2 mg/disc PMRSDJ 1,175,1981
DNA damage human fibroblast 200 Ámol/L CNREA8 42,3783,1982
DNA damage human other cell types 200 Ámol/L CNREA8 42,3783,1982
DNA damage human other cell types 300 Ámol/L/30 minute TOLED5 170,57,2007
DNA damage mammal (species unspecified) lymphocyte 500 Ámol/L JNSVA5 24,263,1978
DNA damage oral
mouse
1 mg/kg MUREAV 577S,1,2005
DNA inhibition human HeLa cell 2,500 Ámol/L MUREAV 92,427,1982
DNA inhibition human other cell types 200 Ámol/L CNREA8 42,3783,1982
DNA inhibition human other cell types 200 mg/L ONCOBS 35,160,1978
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
mutation in microorganisms Neurospora crassa 2 mmol/L (-enzymatic activation step) MAGDA3 10,249,1979
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) POASAD 34,114,1953
mutation in microorganisms Salmonella typhimurium 500 Ág/plate (+/-enzymatic activation step) ABCHA6 45,327,1981
micronucleus test hamster ovary 400 mg/L EMMUEG 26,240,1995
micronucleus test intraperitoneal
mouse
4,500 mg/kg/3 day- continuous EMMUEG 21,160,1993
micronucleus test oral
mouse
30 mg/kg MUREAV 577S,1,2005
gene conversion and mitotic recombination Saccharomyes cerevisiae 300 mg/L PMRSDJ 1,491,1981
other mutation test systems human fibroblast 200 Ámol/L CNREA8 42,3783,1982
other mutation test systems human other cell types 200 Ámol/L CNREA8 42,3783,1982
other mutation test systems mouse liver 500 Ámol/L JNSVA5 24,263,1978
sister chromatid exchange hamster ovary 500 mg/L SCIEAS 236,933,1987
sister chromatid exchange intraperitoneal
mouse
1,600 mg/kg TCMUD8 9,51,1989
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,468,1981
sperm morphology parenteral
silkworm
25 Ág EISOAU 34,367,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 6,680 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ARTODN 64,423,1990
intravenous
mouse
lowest published toxic dose: 800 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOIZAG 8,175,1961
oral
guinea pig
lowest published toxic dose: 19,500 mg/kg (30-58 day pregnant/10 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic ANYAA9 258,401,1975
oral
guinea pig
lowest published toxic dose: 5,800 mg/kg (1-58 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
BEXBAN 57,483,1964
oral
guinea pig
lowest published toxic dose: 2,471 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ANYAA9 258,465,1975
oral
rat
lowest published toxic dose: 2,500 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AJANA2 110,29,1962


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,802,500 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB83-201194


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 643 mg/kg N/R PMRSDJ 1,682,1981
intraperitoneal
mouse
lowest published toxic dose: 90 mg/kg Behavioral: Rigidity (includes catalepsy) PSCHDL 181,71,2005
intravenous
cattle
lowest published toxic dose: 500 mg/kg Peripheral Nerve and Sensation: Fasciculations

Eye: Mydriasis (pupilliary dilation)

Cardiac: Pulse rate increased without fall in BP
JAPTO* 24,513,2004
intravenous
cattle
lowest published toxic dose: 500 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition
JAPTO* 24,513,2004
intravenous
cattle
lowest published toxic dose: 500 mg/kg Nutritional and Gross Metabolic: Changes in: Metabolic acidosis JAPTO* 24,513,2004
intravenous
man
lowest published toxic dose: 2,300 mg/kg/2 day Blood: Oxidant related (GPD deficient) anemia AIMEAS 82,810,1975
intravenous
mouse
lethal dose (50 percent kill): 518 mg/kg N/R RPOBAR 2,269,1970
intravenous
rat
lethal dose (50 percent kill): >4 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)
OYYAA2 12,131,1976
intravenous
woman
lowest published lethal dose: 900 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AIMDAP 145,950,1985
oral
mouse
lethal dose (50 percent kill): 3,367 mg/kg N/R NCISP* JAN1986
oral
mouse
lowest published toxic dose: 250 mg/kg Nutritional and Gross Metabolic: Other changes BPBLEO 27,1093,2004
oral
mouse
lowest published toxic dose: 100 mg/kg Liver: Other changes TXCYAC 246,132,2008
oral
rat
lethal dose (50 percent kill): 11,900 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
OYYAA2 12,131,1976
oral
rat
lethal dose (50 percent kill): 11.9 gm/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
ENTOX* -,182,2005
subcutaneous
rat
lethal dose (50 percent kill): >10 gm/kg N/R OYYAA2 12,131,1976
skin
mouse
lowest published toxic dose: 50 mg/kg Immunological Including Allergic: Increase in cellular immune response FATOAO 47,84,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rat
: 300 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
EJPHAZ 534,202,2006
oral
human
lowest published toxic dose: 72.96 gm/kg/313 week- continuous Tumorigenic: Active as anti-cancer agent JJIND8 92,1881,2000
oral
human
lowest published toxic dose: 600 mg/kg/14 day- intermittent Vascular: BP lowering not characterized in autonomic section

Endocrine: Other changes
PSCHDL 159,319,2002
oral
monkey
lowest published toxic dose: 6,000 mg/kg/30 day- continuous Reproductive: Other effects on male

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 215,237,2006
oral
mouse
lowest published toxic dose: 546 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-247,1983
oral
mouse
lowest published toxic dose: 18,000 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,19,2003
oral
mouse
lowest published toxic dose: 210 mg/kg/2 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 44,46,2005
oral
mouse
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JOETD7 113,503,2007
oral
mouse
lowest published toxic dose: 480,000 mg/kg/480 day- continuous Tumorigenic: Facilitates action of known carcinogens CRNGDP 26,657,2005
oral
rat
lowest published toxic dose: 455 gm/kg/13 week- continuous Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-247,1983
oral
rat
lowest published toxic dose: 2,500 mg/kg/10 day- intermittent Endocrine: Hyperglycemia

Blood: Other changes
FATOBP 159,75,1986
oral
rat
lowest published toxic dose: 7,000 mg/kg/28 day- intermittent Endocrine: Change in gonadotropins

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in ovarian weight
AECTCV 41,83,2001
oral
rat
lowest published toxic dose: 1,200 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 188,117,2003
oral
rat
lowest published toxic dose: 769 mg/kg/25 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOSCF2 73,339,2003
oral
rat
lowest published toxic dose: 2,240 mg/kg/16 week- intermittent Liver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 199,47,2004
oral
rat
lowest published toxic dose: 2,100 mg/kg/12 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 211,26,2005
oral
rat
lowest published toxic dose: 2,800 mg/kg/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 166,27,2006
oral
rat
lowest published toxic dose: 11,200 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 166,27,2006
oral
rat
lowest published toxic dose: 5,600 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 166,27,2006
oral
rat
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 232,170,2007
oral
rat
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Brain and Coverings: Changes in brain weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
NRTXDN 28,490,2007
oral
rat
lowest published toxic dose: 300 mg/kg/30 day- intermittent Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 241,99,2007
oral
rat
lowest published toxic dose: 4,000 mg/kg/20 day- intermittent Behavioral: Altered sleep time (including change in righting reflex) FCLPH* 18,153,2004
oral
rabbit
lowest published toxic dose: 1,680 mg/kg/12 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Impotence

Reproductive: Other effects on male
TXCYAC 207,81,2005
oral
rabbit
lowest published toxic dose: 4,480 mg/kg/16 week- intermittent Behavioral: Food intake (animal)

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
TXCYAC 215,97,2005
oral
rabbit
lowest published toxic dose: 1,680 mg/kg/12 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 235,194,2007
parenteral
rat
lowest published toxic dose: 28 gm/kg/7 day- continuous Vascular: BP lowering not characterized in autonomic section

Vascular: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCLPH* 18(Suppl 1),63,2004
skin
mouse
lowest published toxic dose: 500 mg/kg/10 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984
skin
mouse
lowest published toxic dose: 120 gm/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases ACPSI* 23,813,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ARPTDI 43,97,2003
TOXICOLOGY REVIEW
CMAJAX 164,353,2001
TOXICOLOGY REVIEW
CTOXAO 40,715,2002
TOXICOLOGY REVIEW
TOLED5 140-141,125,2003
TOXICOLOGY REVIEW
APHRER 39,2073,2005
TOXICOLOGY REVIEW
ENTOX* -,182,2005
TOXICOLOGY REVIEW
IJTOFN 24,51,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HTOPA* 1,595,2002
TOXICOLOGY REVIEW
MUREAV 543,191,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0462;
Number of Industries 24;
Total Number of Facilities 5,030;
Number of Occupations 33;
Total Number of Employees Exposed 69,440
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0462;
Number of Industries 41;
Total Number of Facilities 7,888;
Number of Occupations 56;
Total Number of Employees Exposed 137,698;
Total Number of Female Employees Exposed 84,231


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-human lymphocytes; In vitro SCE-human
EPA GENETOX PROGRAM 1988, Positive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor, packaging material, pharmaceutical
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EISOAU Eiyo to Shokuryo. Food and Nutrition. (Tokyo, Japan) V.10-35, 1957-82.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HTOPA*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
MAGDA3 Mechanisms of Ageing and Development. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205)
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
POASAD Proceedings of the Oklahoma Academy of Science. (Oklahoma Academy of Science, c/o Executive Secretary-Treasurer, Southwestern Oklahoma State Univ., Weatherford, OK 73096) V.1- 1910/1920-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a food and feed additive, flavor, packaging material, pharmaceutical

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Natural Product

ALT CAS #: 14536-17-5
ALT CAS #: 30208-61-8
ALT CAS #: 50976-75-5
ALT CAS #: 56533-05-2
ALT CAS #: 57304-74-2
ALT CAS #: 57606-40-3
ALT CAS #: 89924-69-6
ALT CAS #: 129940-97-2
Click Here for Additional Information about RTECS

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