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Asbestos, chrysotile

RTECS #: CI6478500

CAS #: 12001-29-5


UPDATE: May 2009 MW: N/R MF: H4O4Si1/2H2O3/2Mg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 5R04
  2. 7 - 45 Asbestos
  3. Asbestos (ACGIH)
  4. Avibest C
  5. Calidria RG 100
  6. Calidria RG 144
  7. Calidria RG 600
  8. Cassiar AK
  9. Chrysotile
  10. Chrysotile asbestos
  1. Chrysotile asbestos (ACGIH)
  2. Hooker No. 1 chrysotile asbestos
  3. K6 - 30
  4. Metaxite
  5. NCI C61223A
  6. Plastibest 20
  7. RG 600
  8. Serpentine chrysotile
  9. Sylodex
  10. White asbestos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mg/L CRNGDP 8,553,1987
cytogenetic analysis hamster embryo 100 g/L ENVRAL 10,165,1975
cytogenetic analysis hamster ovary 10 mg/L CSHCAL 4,941,1977
cytogenetic analysis human lymphocyte 10 mg/L MUREAV 265,245,1992
cytogenetic analysis intraperitoneal
mouse
50 mg/kg MUREAV 319,303,1993
cytogenetic analysis intraperitoneal
rat
100 mg/kg CNREA8 48,6455,1988
cytogenetic analysis rat other cell types 2 mg/L NASGEJ 3,511,1985
cytogenetic analysis intratracheal
rat
2,900 gm/L ENVRAL 57,175,1992
DNA inhibition hamster lung 62 mg/L TIVIEQ 1,71,1987
unscheduled DNA synthesis human lung 10 mg/L JEPOEC 6(5/6),169,1986
unscheduled DNA synthesis rat other cell types 4 g/cm2 MUREAV 241,361,1990
micronucleus test hamster embryo 500 ng/cm2/48 hour CNREA8 44,5017,1984
micronucleus test hamster lung 3,297 g/L MUREAV 320,253,1994
micronucleus test human other cell types 0.5 ng/L/72 hour MUREAV 559,19,2004
mutation in mammalian somatic cells hamster lung 10 mg/L MUREAV 68,265,1979
morphological transform hamster embryo 250 ng/cm2 PAACA3 24,96,1983
morphological transform mouse other cell types 10 mg/L CSHCAL 4,941,1977
morphological transform rat other cell types 400 ng/cm2 CRNGDP 6,523,1985
other mutation test systems hamster embryo 1 mg/L ENVRAL 10,165,1975
other mutation test systems hamster ovary 10 mg/L MUREAV 116,369,1983
other mutation test systems human fibroblast 10 mg/L MUREAV 116,369,1983
other mutation test systems intratracheal
rat
2,900 gm/L ENVRAL 57,175,1992
sister chromatid exchange hamster ovary 100 g/L ENVRAL 24,325,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
5 gm/L MUREAV 261,9,1991
sex chromosome loss and nondisjunction hamster embryo 500 ng/cm2/48 hour CNREA8 44,5017,1984
sex chromosome loss and nondisjunction hamster lung 40 mg/L CRNGDP 8,553,1987
sex chromosome loss and nondisjunction intraperitoneal
rat
100 mg/kg CNREA8 48,6455,1988
specific locus test hamster ovary 40 mg/L MUREAV 602,14,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 23 mg/m3/7 hour/47 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Adrenal cortex tumors
ENVRAL 10,368,1975
inhalation
man
lowest published toxic concentration: 400 million particles per cubic foot/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Tumors
AEHLAU 28,61,1974
inhalation
rat
lowest published toxic concentration: 11 mg/m3/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
BJCAAI 29,252,1974
inhalation
rat
toxic concentration (other than lowest) : 12 mg/m3/13 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
RRCRBU 39,37,1972
inhalation
rat
toxic concentration (other than lowest) : 10 mg/m3/52 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IAPUDO 30,285,1980
inhalation
rat
toxic concentration (other than lowest) : 11 mg/m3/8 hour/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IAPUDO 30,363,1980
implant
rat
lowest published toxic dose: 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
IARCCD 8,289,1973
intrapleural
rat
lowest published toxic dose: 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
BJCAAI 23,567,1969
intrapleural
rat
lowest published toxic dose: 300 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONAW 20(4),47,1974
intrapleural
rat
toxic dose : 90 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JSOMBS 29,20,1979
intrapleural
rat
toxic dose : 200 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
JNCIAM 48,797,1972
intrapleural
rat
toxic dose : 120 mg/kg/2 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
CALEDQ 17,313,1983
intrapleural
rat
lowest published toxic dose: 300 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONC* -,1077,1991
intrapleural
rat
lowest published toxic dose: 240 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONC* -,1077,1991
intraperitoneal
hamster
lowest published toxic dose: 200 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Other changes
IAPUDO 30,337,1980
intraperitoneal
mouse
lowest published toxic dose: 80 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
ENVRAL 35,277,1984
intraperitoneal
mouse
toxic dose : 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
ENVRAL 27,433,1982
intraperitoneal
rat
lowest published toxic dose: 9 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
ZHPMAT 162,467,1976
intraperitoneal
rat
toxic dose : 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ENVRAL 4,496,1971
intraperitoneal
rat
toxic dose : 28 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NATWAY 59,318,1972
intraperitoneal
rabbit
lowest published toxic dose: 25 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Other changes
IAPUDO 30,337,1980
intratracheal
hamster
toxic dose : 48 mg/kg/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IAPUDO 30,305,1980
intratracheal
mouse
lowest published toxic dose: 200 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PAACA3 15,6,1974
intratracheal
rat
lowest published toxic dose: 13 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
ENVRAL 21,63,1980
multiple
hamster
lowest published toxic dose: 240 gm/kg/35 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens
ANYAA9 132,456,1965
oral
rat
lowest published toxic dose: 7,100 mg/kg/39 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
ARGEAR 46,437,1976
subcutaneous
mouse
lowest published toxic dose: 2,400 mg/kg/13 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
FCTXAV 6,566,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 2.8 fiber/cubic centimeter/5 year Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
ENVRAL 23,292,1980
intrapleural
rat
lowest published toxic dose: 150 mg/kg Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Changes in: Fe
ABBIA4 311,13,1994
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Immunological Including Allergic: Increase in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
EVHPAZ 51,147,1983
intraperitoneal
rat
lowest published lethal dose: 300 mg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Peritonitis
AJPAA4 70,291,1973
intratracheal
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 207,221,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/6 hour/78 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 7,503,1995
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/48 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INHTE5 7,503,1995
inhalation
rat
lowest published toxic concentration: 8,210 g/m3/6 hour/20 day- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) TXAPA9 137,67,1996
intratracheal
rat
lowest published toxic dose: 195 mg/kg/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
GISAAA -,35,1993
oral
rat
lowest published toxic dose: 10,867 mg/kg/78 week- continuous Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Other carbohydrates
TOLED5 39,205,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 fibers/cubic centimeter DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 2,17,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 2,17,1973
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 14,11,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 14,11,1977
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,106,1987
TOXICOLOGY REVIEW
31BYAP -,93,1974
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 fiber/cubic centimeter (fiber > 5 um) DTLWS* 3,33,1973
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1001,1987
Occupational Exposure Limit - AUSTRALIA 0.1 f/mL, JUL2008
Occupational Exposure Limit - KOREA time-weighted average 0.1 fiber/cm3, carcinogen, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 fibers/cubic centimeter, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 fiber/ml, short term exposure limit 6 fibers/ml, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 fiber/cm3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 f/cubic centimeter, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 f/cubic centimeter, Carcinogen, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASBESTOS-air 100 minute time-weighted average 0.1 fiber/cubic centimeter in a 400L air sample NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1575;
Number of Industries 45;
Total Number of Facilities 5,924;
Number of Occupations 48;
Total Number of Employees Exposed 92,033;
Total Number of Female Employees Exposed 13,262


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: TRP reversion
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Asbestos (bulk) by PLM, 9002; by PCM, 7400; by TEM, 7402
NIOSH Analytical Method, 1994: Asbestos, chrysotile by XRD, 9000
NTP Carcinogenesis Studies (feed):some evidence:rat NTPTR* NTP-TR-295,1985
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:hamster
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

31BYAP "Experimental Lung Cancer: Carcinogenesis and Bioassays, International Symposium, 1974," Karbe, E., and J.F. Park, eds., Springer-Verlag New York, Inc., 1974
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold Spring Harbor, NY) V.1-10, 1974-83.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JSOMBS Journal of the Society of Occupational Medicine. (John Wright & Sons, Ltd., Techno House, Redcliffe Way, Bristol BS1 6NX, UK) V.23- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NASGEJ NATO ASI Series, Series G: Ecological Sciences. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1983-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Natural Product

ALT CAS #: 12426-98-1
ALT CAS #: 61076-97-9
Click Here for Additional Information about RTECS

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