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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic acid, lead(2+) salt(1:1)

RTECS #

CG0980000

CAS #

7784-40-9; 37196-28-4

Updated

September 201

Molecular Weight

347.12

Molecular Formula

AsHO4·Pb

Synonyms

Acid lead arsenate
Acid lead orthoarsenate
Arsenate of lead
Dibasic lead arsenate
Gypsine
Lead acid arsenate
Lead arsenate
Lead arsenate (ACGIH:OSHA)
Lead arsenate (standard)
Lead hydrogenarsenate
Ortho L40 dust
Schultenite
Standard lead arsenate

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 128 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 51(1),74,1986
intraperitoneal/mouse lethal dose (50 percent kill): 128 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
VCVN1* -,428,1988
intraperitoneal/mouse lethal dose (50 percent kill): 1285 mg/kgVCVN5* -,89,1993
oral/chicken lethal dose (50 percent kill): 450 mg/kgPCOC** -,653,1966
oral/mammal (species unspecified) lethal dose (50 percent kill): 10 mg/kgYKYUA6 37,1323,1986
oral/mouse lethal dose (50 percent kill): 1526 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GISAAA 51(1),74,1986
oral/mouse lethal dose (50 percent kill): 1500 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
VCVN1* -,428,1988
oral/mouse lethal dose (50 percent kill): 1526 mg/kgVCVN5* -,89,1993
oral/rabbit lethal dose (50 percent kill): 100 mg/kgJPIFAN (3),5,1970
oral/rat lethal dose (50 percent kill): 100 mg/kgPCOC** -,653,1966
oral/rat lethal dose (50 percent kill): 3100 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
VCVN1* -,428,1988
skin/rat lethal dose (50 percent kill): >2400 mg/kgTXAPA9 14,515,1969
unreported route/mammal (species unspecified) lowest published lethal dose: 10 mg/kgYKYUA6 38,89,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2420 mg/kg/11D- intermittentGastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes
VCVN1* -,428,1988
oral/rat lowest published toxic dose: 36 gm/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
PHRPA6 56,1610,1941
oral/rat lowest published toxic dose: 2420 mg/kg/11D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Interstitial nephritis
GISAAA 51(1),74,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(Pb)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 1,40,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal NO EVIDENCEIMEMDT 2,48,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,39,1980
TOXICOLOGY REVIEW85DHAX As,-,1977
TOXICOLOGY REVIEWENVRAL 13,36,1977

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,187,1998
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg(Pb)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0.15 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Pb)/m3, KZG-week 0.8 mg(Pb)/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.15 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air10H time-weighted average <0.1 mg(Pb)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
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