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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic acid, disodium salt, heptahydrate

RTECS #

CG0900000

CAS #

10048-95-0

Updated

September 201

Molecular Weight

427.00

Molecular Formula

AsHO4·2Na·7H2O

Synonyms

Dibasic sodium arsenate heptahydrate
Disodium arsenate, heptahydrate
Sodium acid arsenate, heptahydrate
Sodium arsenate heptahydrate
Sodium arsenate, dibasic, heptahydrate
Sodium arseniate heptahydrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human7200 nmol/LMUREAV 88,73,1981
Cytogenetic Analysislymphocyte/human10 mg/LENMUDM 3,597,1981
Cytogenetic Analysisfibroblast/human16 µmol/LMUREAV 357,123,1996
Cytogenetic Analysisembryo/hamster10 mg/LENMUDM 3,597,1981
Cytogenetic Analysisoral/Drosophila melanogaster454 ppmSOGEBZ 10,608,1974
Cytogenetic Analysisovary/hamster10 mmol/L/30MTXAPA9 201,156,2004
Cytogenetic Analysislymphocyte/human50 µmol/L/66HEMMUEG 42,192,2003
Cytogenetic Analysisother cell types/mouse3.2 µmol/L/10DMUREAV 675,66,2009
DNA Damageother cell types/human10 mmol/L/3HMUTAEX 19,129,2004
micronucleus testlymphocyte/human16 µmol/L/20HMUTAEX 22,255,2007
micronucleus testmultiple/other fish75 µg/L/30D-continuousMUTAEX 20,291,2005
morphological transformfibroblast/mouse1 mg/L/10DMUREAV 702,100,2010
morphological transformfibroblast/human2500 nmol/LCNREA8 47,3815,1987
sister chromatid exchangeembryo/hamster1 mg/LENMUDM 3,597,1981
sister chromatid exchangefibroblast/hamster10 mg/LMUREAV 104,141,1982
sister chromatid exchangeovary/hamster10 mmol/L/30MTXAPA9 201,156,2004
sister chromatid exchangelymphocyte/human5 mg/LENMUDM 3,597,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 40 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
TJADAB 6,235,1972
intraperitoneal/mouse 40 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** CONF-771017
intraperitoneal/mouse 40 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Body wall
NTIS** CONF-771017
intraperitoneal/mouse 45 mg/kg (9D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)AEHLAU 24,62,1972
intraperitoneal/hamster 20 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
ANEMDG 176,345,1987
intraperitoneal/rat 30 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 10,153,1974
intraperitoneal/rat 20 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 10,153,1974
intraperitoneal/rat 20 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 10,153,1974
intraperitoneal/rat 35 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 60,283,1999
intraperitoneal/mouse 45 mg/kg (8D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TCMUD8 22,315,2002
intravenous/hamster 15 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
AEHLAU 22,557,1971
intravenous/hamster 15 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Eye, ear
AEHLAU 22,557,1971
intravenous/hamster 20 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemEXMPA6 34,145,1981
oral/mouse 120 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** CONF-771017
oral/mouse 120 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
EVHPAZ 19,219,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 60 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/jkhInhibitor Concentration (50 percent kill): 300 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/paaInhibitor Concentration (50 percent kill): 300 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 250 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
intramuscular/mouse lethal dose (50 percent kill): 87360 µg/kgEXMDA4 (440),312,1978
oral/mouse lowest published toxic dose: 88 mg/kgLiver: Liver function tests impaired

Liver: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed
JOETD7 134,26,2011
subcutaneous/guinea pig lowest published lethal dose: 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
BMJOAE 2,217,1913
Tank with water/Urchin lowest published toxic concentration: 0.011 mg/L/48HReproductive: Other developmental abnormalitiesTIVIEQ 39,247,1997

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
multiple/non-mammalian species lowest published toxic concentration: 43.78 gm/m3/4D- continuousBlood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 48,2848,2010
multiple/non-mammalian species lowest published toxic concentration: 4.378 gm/m3/5D- continuousEndocrine: Hyperglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
FCTOD7 48,2848,2010
oral/mouse lowest published toxic dose: 43 mg/kg/4W- continuousLiver: Other changes

Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTEHD6 49,177,1996
oral/mouse lowest published toxic dose: 2520 mg/kg/48W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOSCF2 55,460,2000
oral/rat lowest published toxic dose: 3 mg/kg/30D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOPADD 32,64,2004
oral/rat lowest published toxic dose: 12.2 mg/kg/122D- continuousLiver: Fatty liver degeneration

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOPADD 32,64,2004
subcutaneous/mouse lowest published toxic dose: 3202 mg/kg/15W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 55,460,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
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