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Arsenic acid, disodium salt, heptahydrate

RTECS #: CG0900000

CAS #: 10048-95-0


UPDATE: May 2009 MW: 427.00 MF: AsHO4•2Na•7H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Dibasic sodium arsenate heptahydrate
  2. Disodium arsenate, heptahydrate
  3. Sodium acid arsenate, heptahydrate
  1. Sodium arsenate, dibasic, heptahydrate
  2. Sodium arsenate heptahydrate
  3. Sodium arseniate heptahydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
Drosophila melanogaster
454 ppm SOGEBZ 10,608,1974
cytogenetic analysis hamster embryo 10 mg/L ENMUDM 3,597,1981
cytogenetic analysis hamster ovary 10 mmol/L/30 minute TXAPA9 201,156,2004
cytogenetic analysis human leukocyte 7,200 nmol/L MUREAV 88,73,1981
cytogenetic analysis human lymphocyte 10 mg/L ENMUDM 3,597,1981
cytogenetic analysis human fibroblast 16 µmol/L MUREAV 357,123,1996
cytogenetic analysis human lymphocyte 50 µmol/L/66 hour EMMUEG 42,192,2003
DNA damage human other cell types 10 mmol/L/3 hour MUTAEX 19,129,2004
micronucleus test multiple
other fish
75 µg/L/30 day- continuous MUTAEX 20,291,2005
morphological transform human fibroblast 2,500 nmol/L CNREA8 47,3815,1987
sister chromatid exchange hamster embryo 1 mg/L ENMUDM 3,597,1981
sister chromatid exchange hamster fibroblast 10 mg/L MUREAV 104,141,1982
sister chromatid exchange hamster ovary 10 mmol/L/30 minute TXAPA9 201,156,2004
sister chromatid exchange human lymphocyte 5 mg/L ENMUDM 3,597,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 20 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
ANEMDG 176,345,1987
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
TJADAB 6,235,1972
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** CONF-771017
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Body wall
NTIS** CONF-771017
intraperitoneal
mouse
lowest published toxic dose: 45 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) AEHLAU 24,62,1972
intraperitoneal
mouse
lowest published toxic dose: 45 mg/kg (8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TCMUD8 22,315,2002
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 10,153,1974
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 10,153,1974
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 10,153,1974
intraperitoneal
rat
lowest published toxic dose: 35 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 60,283,1999
intravenous
hamster
lowest published toxic dose: 15 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
AEHLAU 22,557,1971
intravenous
hamster
lowest published toxic dose: 15 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Eye, ear
AEHLAU 22,557,1971
intravenous
hamster
lowest published toxic dose: 20 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system EXMPA6 34,145,1981
oral
mouse
lowest published toxic dose: 120 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** CONF-771017
oral
mouse
lowest published toxic dose: 120 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
EVHPAZ 19,219,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lethal dose (50 percent kill): 87,360 µg/kg N/R EXMDA4 (440),312,1978
subcutaneous
guinea pig
lowest published lethal dose: 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
BMJOAE 2,217,1913


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 43 mg/kg/4 week- continuous Liver: Other changes

Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTEHD6 49,177,1996
oral
mouse
lowest published toxic dose: 2,520 mg/kg/48 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOSCF2 55,460,2000
oral
rat
lowest published toxic dose: 3 mg/kg/30 day- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOPADD 32,64,2004
oral
rat
lowest published toxic dose: 12.2 mg/kg/122 day- continuous Liver: Fatty liver degeneration

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOPADD 32,64,2004
subcutaneous
mouse
lowest published toxic dose: 3,202 mg/kg/15 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 55,460,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(As)/m3, OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ANEMDG Anatomy and Embryology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.146- 1974-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXMDA4 International Congress Series--Excerpta Medica. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) No.1- 1952-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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