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Arsenic acid, disodium salt

RTECS #: CG0875000

CAS #: 7778-43-0


UPDATE: May 2009 MW: 185.91 MF: AsHO4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Disodium arsenate
  2. Disodium arsenic acid
  3. Disodium hydrogen arsenate
  4. Disodium hydrogen orthoarsenate
  1. Disodium monohydrogen arsenate
  2. Sodium acid arsenate
  3. Sodium arsenate, dibasic
  4. Sodium arsenate dibasic, anhydrous


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 80 µmol/L ENMUDM 4,493,1982
cytogenetic analysis hamster embryo 64 µmol/L CRNGDP 6,1421,1985
cytogenetic analysis hamster ovary 1 µmol/L ENMUDM 4,493,1982
cytogenetic analysis human other cell types 50 µmol/L TIVIEQ 5,353,1991
DNA damage human other cell types 2 µmol/L/1 hour MUREAV 615,75,2007
DNA inhibition human other cell types 10 µmol/L AKEDAX 237,819,1970
DNA inhibition human lymphocyte 100 nmol/L ADMFAU 242,343,1972
DNA inhibition intraperitoneal
rat
45 mg/kg ENVRAL 28,1,1982
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
DNA repair Bacillus subtilis 100 mmol/L MUREAV 77,109,1980
DNA repair Escherichia coli 130 µg/well ENMUDM 3,429,1981
mutation in microorganisms mouse lymphocyte 18 mg/L (+enzymatic activation step) JTEHD6 9,367,1982
micronucleus test multiple
other fish
5,055.96 ppb/30 day- continuous MUTAEX 20,291,2005
morphological transform hamster embryo 2,500 µg/L CNREA8 39,1008,1979
morphological transform mouse embryo 20 µmol/L CRNGDP 8,803,1987
other mutation test systems human lymphocyte 100 nmol/L ADMFAU 242,343,1972
other mutation test systems intraperitoneal
rat
45 mg/kg ENVRAL 28,1,1982
sister chromatid exchange hamster embryo 10 µmol/L CRNGDP 6,1421,1985
sister chromatid exchange hamster ovary 1 µmol/L ENMUDM 4,493,1982
sister chromatid exchange human lymphocyte 2,500 µg/L MUREAV 119,415,1983
specific locus test parenteral
Drosophila melanogaster
1,080 µmol/L EMMUEG 25,288,1995
specific locus test oral
Drosophila melanogaster
10 µmol/L EMMUEG 25,288,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 17.9 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 71,124,2004
intraperitoneal
mouse
lowest published toxic dose: 17.9 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
BDERB* 71,124,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published lethal dose: 34,720 µg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
JPETAB 58,454,1936


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 450 mg/kg/90 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BECTA6 50,100,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(As)/m3, OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in dyeing with turkey-red oil and in printing fabrics
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

ADMFAU Archiv fuer Dermatologische Forschung. (Berlin, Ger.) V.240-252, 1971-75. For publisher information, see ADREDL.
AKEDAX Archiv fuer Klinische und Experimentelle Dermatologie. (Berlin, Ger.) V.201-239, 1955-71. For publisher information, see ADMFAU.
BDERB*
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used in dyeing with turkey-red oil and in printing fabrics

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 55957-14-7
Click Here for Additional Information about RTECS

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