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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic acid, disodium salt

RTECS #

CG0875000

CAS #

7778-43-0; 55957-14-7

Updated

December 2013

Molecular Weight

185.91

Molecular Formula

AsHO4·2Na

Synonyms

Disodium arsenate
Disodium arsenic acid
Disodium hydrogen arsenate
Disodium hydrogen orthoarsenate
Disodium monohydrogen arsenate
Sodium acid arsenate
Sodium arsenate dibasic, anhydrous
Sodium arsenate, dibasic

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/human50 µmol/LTIVIEQ 5,353,1991
Cytogenetic Analysisovary/hamster80 µmol/LENMUDM 4,493,1982
Cytogenetic Analysisembryo/hamster64 µmol/LCRNGDP 6,1421,1985
Cytogenetic Analysisovary/hamster1 µmol/LENMUDM 4,493,1982
DNA Damageother cell types/human2 µmol/L/1HMUREAV 615,75,2007
DNA inhibitionintraperitoneal/rat45 mg/kgENVRAL 28,1,1982
DNA inhibitionother cell types/human10 µmol/LAKEDAX 237,819,1970
DNA inhibitionlymphocyte/human100 nmol/LADMFAU 242,343,1972
DNA repair/Escherichia coli130 µg/wellENMUDM 3,429,1981
DNA repair/Bacillus subtilis50 mmol/LMUREAV 31,185,1975
DNA repair/Bacillus subtilis100 mmol/LMUREAV 77,109,1980
micronucleus testlymphocyte/human2 µmol/L/48HMUTAEX 22,255,2007
micronucleus testmultiple/other fish5055.96 ppb/30D-continuousMUTAEX 20,291,2005
morphological transformembryo/mouse20 µmol/LCRNGDP 8,803,1987
morphological transformembryo/hamster2500 µg/LCNREA8 39,1008,1979
mutation in microorganismslymphocyte/mouse18 mg/L (+enzymatic activation step)JTEHD6 9,367,1982
other mutation test systemsintraperitoneal/rat45 mg/kgENVRAL 28,1,1982
other mutation test systemslymphocyte/human100 nmol/LADMFAU 242,343,1972
sister chromatid exchangelymphocyte/human2500 µg/LMUREAV 119,415,1983
sister chromatid exchangeembryo/hamster10 µmol/LCRNGDP 6,1421,1985
sister chromatid exchangeovary/hamster1 µmol/LENMUDM 4,493,1982
specific locus testparenteral/Drosophila melanogaster1080 µmol/LEMMUEG 25,288,1995
specific locus testoral/Drosophila melanogaster10 µmol/LEMMUEG 25,288,1995

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 17.9 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
BDERB* 71,124,2004
intraperitoneal/mouse 17.9 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 71,124,2004
oral/mouse 6.2 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)TOLED5 180,59,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/mzxInhibitor Concentration Low: 10 µmol/L/4DImmunological Including Allergic: Decrease in humoral immune responseTXAPA9 245,344,2010
intraperitoneal/rat lowest published lethal dose: 34720 µg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
JPETAB 58,454,1936

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/domestic animal lowest published toxic dose: 56 mg/kg/28D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesFCTOD7 50,1946,2012
oral/domestic animal lowest published toxic dose: 168 mg/kg/84D- intermittentLiver: Fatty liver degeneration

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes
FCTOD7 50,1946,2012
oral/rat lowest published toxic dose: 450 mg/kg/90D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
BECTA6 50,100,1993

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen
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