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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic acid (H3AsO4)

RTECS #

CG0700000

CAS #

7778-39-4; 1327-52-2

Updated

September 201

Molecular Weight

141.95

Molecular Formula

AsH3O4

Synonyms

Acide arsenique liquide (French)
Crab grass killer
Desiccant L-10
HI-Yield desiccant H-10
Orthoarsenic acid
RCRA waste number P010
Zotox
Zotox Crab Grass Killer

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human7200 nmol/LMUREAV 88,73,1981
DNA Damageintraperitoneal/mouse10 mg/kgMUREAV 467,83,2000
micronucleus testintraperitoneal/mouse20 mg/kgMUREAV 389,3,1997

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 30 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system
JTSCDR 4,405,1979
intraperitoneal/mouse 40 mg/kg (7-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 15,30A,1977
oral/mouse 120 mg/kg (7-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 15,30A,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/chicken lowest published lethal dose: 125 mg/kgFDWU** -,-,1931
oral/Dog lowest published lethal dose: 10 mg/kgFDWU** -,-,1931
oral/pigeon lowest published lethal dose: 100 mg/kgFDWU** -,-,1931
oral/rabbit lowest published lethal dose: 5 mg/kgFDWU** -,-,1931
oral/rat lethal dose (50 percent kill): 48 mg/kgFMCHA2 -,C27,1991

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 133,1,2002
TOXICOLOGY REVIEWIMEMDT 84,39,2004
TOXICOLOGY REVIEWEMMUEG 47,6,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(As)/m3, NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84479; Number of Industries 5; Total Number of Facilities 249; Number of Occupations 9; Total Number of Employees Exposed 4415; Total Number of Female Employees Exposed 1111
National Occupational Hazard Survey 1974Hazard Code 84479; Number of Industries 2; Total Number of Facilities 30; Number of Occupations 2; Total Number of Employees Exposed 166

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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