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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenious acid, potassium salt

RTECS #

CG3800000

CAS #

10124-50-2

Updated

September 201

Molecular Weight

399.65

Molecular Formula

AsH3O3·xK

Synonyms

Arsenenous acid, potassium salt
Arsenite de potassium (French)
Arsonic acid, potassium salt
Kaliumarsenit (German)
NSC 3060
Potassium metaarsenite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human1 µmol/L/48HCNREA8 25,980,1965

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/child toxic dose: 390 mg/kg/3Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
AIMEAS 61,296,1964
oral/man lowest published toxic dose: 214 mg/kg/15Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
GASTAB 68,1582,1975
oral/man toxic dose: 7560 mg/kg/26W- continuousTumorigenic: Carcinogenic by RTECS criteria

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Tumors
ANSUA5 99,348,1934
oral/man toxic dose: 441 mg/kg/3W- continuousTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
ANSUA5 99,348,1934
skin/mouse lowest published toxic dose: 576 mg/kg/12W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
BMJOAE 2,1107,1922

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/Dog lowest published lethal dose: 2 mg/kgHBAMAK 4,1307,1935
intravenous/rabbit lowest published lethal dose: 6 mg/kgHBAMAK 4,1307,1935
oral/Dog lowest published lethal dose: 3 mg/kgHBAMAK 4,1307,1935
oral/human lowest published toxic dose: 74 mg/kgLiver: Other changes

Skin: After systemic exposure: Dermatitis, other
LANCAO 1,269,1953
oral/rat lethal dose (50 percent kill): 14 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Dehydration
AFDOAQ 15,122,1951
skin/rat lethal dose (50 percent kill): 150 mg/kgPHJOAV 185,361,1960
subcutaneous/cat lowest published lethal dose: 5 mg/kgHBAMAK 4,1307,1935
subcutaneous/Dog lowest published lethal dose: 700 µg/kgHBAMAK 4,1307,1935
subcutaneous/guinea pig lowest published lethal dose: 9 mg/kgHBAMAK 4,1307,1935
subcutaneous/mouse lowest published lethal dose: 16 mg/kgHBAMAK 4,1307,1935
subcutaneous/pigeon lowest published lethal dose: 12 mg/kgFDWU** -,-,1931
subcutaneous/rabbit lowest published lethal dose: 8 mg/kgHBAMAK 4,1307,1935

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 2,48,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,39,1980
TOXICOLOGY REVIEW85DHAX As,-,1977
TOXICOLOGY REVIEWENVRAL 16,139,1978

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
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