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Arsenious acid, potassium salt

RTECS #: CG3800000

CAS #: 10124-50-2


UPDATE: May 2009 MW: 399.65 MF: AsH3O3xK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Arsenenous acid, potassium salt
  2. Arsenite de potassium (French)
  3. Arsonic acid, potassium salt
  1. Kaliumarsenit (German)
  2. NSC 3060
  3. Potassium metaarsenite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human leukocyte 1 mol/L/48 hour CNREA8 25,980,1965


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
child
toxic dose : 390 mg/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
AIMEAS 61,296,1964
oral
man
lowest published toxic dose: 214 mg/kg/15 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
GASTAB 68,1582,1975
oral
man
toxic dose : 7,560 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Tumors
ANSUA5 99,348,1934
oral
man
toxic dose : 441 mg/kg/3 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
ANSUA5 99,348,1934
skin
mouse
lowest published toxic dose: 576 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
BMJOAE 2,1107,1922


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
dog
lowest published lethal dose: 2 mg/kg N/R HBAMAK 4,1307,1935
intravenous
rabbit
lowest published lethal dose: 6 mg/kg N/R HBAMAK 4,1307,1935
oral
dog
lowest published lethal dose: 3 mg/kg N/R HBAMAK 4,1307,1935
oral
human
lowest published toxic dose: 74 mg/kg Liver: Other changes

Skin: After systemic exposure: Dermatitis, other
LANCAO 1,269,1953
oral
rat
lethal dose (50 percent kill): 14 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Dehydration
AFDOAQ 15,122,1951
subcutaneous
cat
lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
dog
lowest published lethal dose: 700 g/kg N/R HBAMAK 4,1307,1935
subcutaneous
guinea pig
lowest published lethal dose: 9 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
mouse
lowest published lethal dose: 16 mg/kg N/R HBAMAK 4,1307,1935
subcutaneous
pigeon
lowest published lethal dose: 12 mg/kg N/R FDWU** -,-,1931
subcutaneous
rabbit
lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1307,1935
skin
rat
lethal dose (50 percent kill): 150 mg/kg N/R PHJOAV 185,361,1960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
TOXICOLOGY REVIEW
85DHAX As,-,1977
TOXICOLOGY REVIEW
ENVRAL 16,139,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
ANSUA5 Annals of Surgery. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1885-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931
GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-

Used in veterinary medicine, and for chronic dermatitis in man

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data

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