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Arsenious acid, monosodium salt

RTECS #: CG3675000

CAS #: 7784-46-5

UPDATE: May 2009 MW: 129.91 MF: AsO2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Arsenenous acid, sodium salt (9CI)
  2. Arsenite de sodium (French)
  3. Atlas A
  4. Chem Pels C
  5. Chem - Sen 56
  6. Kill - All
  1. Penite
  2. Prodalumnol
  3. Prodalumnol double
  4. Sodanit
  5. Sodium arsenite
  6. Sodium metaarsenite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1 µmol/L ENMUDM 4,493,1982
cytogenetic analysis hamster embryo 6,200 nmol/L CRNGDP 6,1421,1985
cytogenetic analysis hamster lung 10 µmol/L/24 hour MUTAEX 17,99,2002
cytogenetic analysis hamster ovary 1 mmol/L/30 minute TXAPA9 201,156,2004
cytogenetic analysis hamster embryo 4 µmol/L/24 hour MUREAV 603,111,2006
cytogenetic analysis human other cell types 8 µmol/L TIVIEQ 5,353,1991
cytogenetic analysis human lymphocyte 1 mg/L ENMUDM 3,597,1981
cytogenetic analysis human leukocyte 1 nmol/L AEMBAP 91,117,1978
cytogenetic analysis human fibroblast 1 nmol/L AEMBAP 91,117,1978
cytogenetic analysis human lung 2,900 pmol/L MUREAV 16,332,1972
cytogenetic analysis human lymphocyte 1 µmol/L/48 hour MUTAEX 19,223,2004
cytogenetic analysis human lymphocyte 2.5 µmol/L/66 hour EMMUEG 42,192,2003
cytogenetic analysis mouse lymphocyte 1,500 µg/L MUREAV 386,279,1997
cytogenetic analysis oral
mouse 		2,500 µg/kg FCTOD7 38,735,2000
cytogenetic analysis mouse liver 125 nmol/L/24 week TOXID9 72,215,2003
cytogenetic analysis oral
mouse 		140 mg/kg/10 week EMMUEG 44,179,2004
cytogenetic analysis mouse other cell types 20 µmol/L/4 hour MUREAV 634,40,2007
DNA damage hamster ovary 1 µmol/L/4 hour EMMUEG 44,83,2004
DNA damage human lung 1 µmol/L MUREAV 302,97,1993
DNA damage human lymphocyte 200 µmol/L EMMUEG 23,299,1994
DNA damage human liver 1 µmol/L CRNGDP 21,701,2000
DNA damage human fibroblast 5 µmol/L/2 hour MUREAV 498,47,2001
DNA damage human other cell types 1 mmol/L/6 hour TOXID9 44,32,2005
DNA damage human other cell types 0.1 mmol/L/30 minute MUTAEX 19,129,2004
DNA damage human other cell types 2 µmol/L/1 hour MUREAV 615,75,2007
DNA damage mammal (species unspecified) other cell types 250 µg/L/16 day CNREA8 67,5239,2007
DNA damage oral
mouse 		100 mg/kg MUREAV 386,315,1997
DNA damage mouse other cell types 100 µmol/L/120 minute MUREAV 603,121,2006
DNA damage other fish 1 µmol/L/4 hour EMMUEG 44,83,2004
DNA inhibition human fibroblast 50 µmol/L IVTOE4 1,103,1987
DNA inhibition human HeLa cell 200 µmol/L CRNGDP 13,2389,1992
DNA inhibition human HeLa cell 5 µmol/L/1 hour MUREAV 493,31,2001
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
DNA repair Escherichia coli 63 µg/well ENMUDM 3,429,1981
unscheduled DNA synthesis human Ascites tumor 0.25 µmol/L/6 week EMMUEG 41,322,2003
unscheduled DNA synthesis other microorganisms 30 µmol/L ECREAL 180,161,1989
mutation in microorganisms Escherichia coli 160 µmol/L (-enzymatic activation step) MUREAV 31,185,1975
mutation in microorganisms Saccharomyes cerevisiae 100 mmol/L (-enzymatic activation step) MUREAV 117,149,1983
micronucleus test hamster ovary 50 µmol/L MUREAV 319,135,1993
micronucleus test hamster lung 10 µmol/L/6 hour MUTAEX 17,99,2002
micronucleus test hamster ovary 1 µmol/L/24 hour EMMUEG 44,83,2004
micronucleus test human lymphocyte 3 µmol/L EMMUEG 13,34,1989
micronucleus test human fibroblast 5 µmol/L MUREAV 440,75,1999
micronucleus test human liver 10 µmol/L/24 hour MUREAV 514,245,2002
micronucleus test human mammary gland 5 µmol/L/46 hour EMMUEG 40,236,2002
micronucleus test human mammary gland 10 µmol/L/8 hour EMMUEG 40,236,2002
micronucleus test human lymphocyte 80 µmol/L/2 hour EMMUEG 39,323,2002
micronucleus test human lymphocyte 2 µmol/L/24 hour EMMUEG 39,323,2002
micronucleus test human lymphocyte 2 µmol/L/48 hour EMMUEG 39,323,2002
micronucleus test intraperitoneal
mouse 		5 mg/kg MUREAV 147,290,1985
micronucleus test oral
mouse 		2,500 µg/kg EMMUEG 21,383,1993
micronucleus test oral
mouse 		20 mg/kg/4 day EMMUEG 40,71,2002
micronucleus test mouse lymphocyte 80 µmol/L/2 hour EMMUEG 39,323,2002
micronucleus test mouse lymphocyte 8 µmol/L/24 hour EMMUEG 39,323,2002
micronucleus test mouse lymphocyte 4 µmol/L/48 hour EMMUEG 39,323,2002
micronucleus test oral
mouse 		70 mg/kg/7 day- intermittent MUREAV 632,37,2007
micronucleus test other fish 1 µmol/L/48 hour EMMUEG 44,83,2004
micronucleus test pig lymphocyte 80 µmol/L/2 hour EMMUEG 39,323,2002
micronucleus test pig lymphocyte 8 µmol/L/24 hour EMMUEG 39,323,2002
micronucleus test rat lymphocyte 40 µmol/L/2 hour EMMUEG 39,323,2002
micronucleus test rat lymphocyte 2 µmol/L/24 hour EMMUEG 39,323,2002
micronucleus test rat lymphocyte 4 µmol/L/48 hour EMMUEG 39,323,2002
mutation in mammalian somatic cells mouse lymphocyte 1,500 µg/L JTEHD6 9,367,1982
mutation in mammalian somatic cells rat mammary gland 500 nmol/L/24 week MOCAE8 30,79,2001
morphological transform hamster embryo 2 µmol/L CRNGDP 6,1421,1985
morphological transform hamster embryo 1 µmol/L/48 hour TXCYAC 203,155,2004
morphological transform human fibroblast 1 µmol/L CNREA8 47,3815,1987
morphological transform human Ascites tumor 0.25 µmol/L/6 week EMMUEG 41,322,2003
morphological transform mouse embryo 6 µmol/L CRNGDP 8,803,1987
morphological transform mouse fibroblast 0.1 µmol/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
other mutation test systems human lymphocyte 770 nmol/L SWEHDO 7,277,1981
sister chromatid exchange hamster ovary 1 µmol/L ENMUDM 4,493,1982
sister chromatid exchange hamster embryo 800 nmol/L CRNGDP 6,1421,1985
sister chromatid exchange hamster fibroblast 1 mg/L MUREAV 104,141,1982
sister chromatid exchange hamster ovary 1 mmol/L/30 minute TXAPA9 201,156,2004
sister chromatid exchange human lymphocyte 3,900 nmol/L SWEHDO 7,277,1981
sister chromatid exchange mouse liver 125 nmol/L/24 week TOXID9 72,215,2003
sex chromosome loss and nondisjunction human lymphocyte 1 pmol/L MUREAV 334,365,1995
specific locus test parenteral
Drosophila melanogaster 		770 µmol/L EMMUEG 25,288,1995
specific locus test oral
Drosophila melanogaster 		8 µmol/L EMMUEG 25,288,1995
specific locus test hamster other cell types 23 µmol/L/24 hour EMMUEG 35,114,2000
specific locus test hamster ovary 60 µmol/L/24 hour MUREAV 602,14,2006
specific locus test human Ascites tumor 0.1 µmol/L/6 week EMMUEG 41,322,2003
specific locus test oral
mouse 		140 mg/kg/10 week EMMUEG 44,179,2004
specific locus test mouse other cell types 20 µmol/L/4 hour MUREAV 634,40,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 5 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 23,40A,1981
intraperitoneal
hamster 		lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BECTA6 29,671,1982
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BECTA6 7,216,1972
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		BECTA6 7,216,1972
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system BECTA6 7,216,1972
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (9 day pregnant) Reproductive: Other developmental abnormalities EVHPAZ 19,219,1977
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg (8 day pregnant) Reproductive: Effects on newborn: Sex ratio BDERE* 67,231,2003
intraperitoneal
mouse 		lowest published toxic dose: 7.5 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		BDERB* 71,124,2004
intraperitoneal
mouse 		lowest published toxic dose: 7.5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		BDERB* 71,124,2004
intraperitoneal
mouse 		lowest published toxic dose: 7.5 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		BDERB* 68,335,2003
intraperitoneal
rat 		lowest published toxic dose: 11 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear 		TJADAB 23,66A,1981
intraperitoneal
rat 		lowest published toxic dose: 11 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 23,66A,1981
intraperitoneal
rat 		lowest published toxic dose: 7 mg/kg (4-10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXCYAC 234,10,2007
intravenous
hamster 		lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system EXMPA6 34,145,1981
intravenous
hamster 		lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EXMPA6 34,145,1981
oral
hamster 		lowest published toxic dose: 5 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 23,40A,1981
oral
hamster 		lowest published toxic dose: 25 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BECTA6 29,671,1982
oral
mouse 		lowest published toxic dose: 40 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TJADAB 21,27A,1980
oral
mouse 		lowest published toxic dose: 30 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Physical 		PSYBEC 24,227,1996
oral
mouse 		lowest published toxic dose: 45 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		BECTA6 26,749,1981
oral
mouse 		lowest published toxic dose: 300 mg/kg (15 day prior to copulation/1-15 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system ARPTAF 57(2),52,1995
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system TOXID9 72,214,2003
oral
mouse 		lowest published toxic dose: 6 mg/kg (10 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		AECTCV 42,93,2002
oral
mouse 		lowest published toxic dose: 2.2 mg/kg (8-18 day pregnant) Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Delayed effects 		TXCYAC 198,31,2004
oral
mouse 		lowest published toxic dose: 93.5 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Tumorigenic effects: Transplacental tumorigenesis 		TOXID9 44,30,2005
oral
mouse 		lowest published toxic dose: 75.35 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic 		TXCYAC 208,357,2005
oral
mouse 		lowest published toxic dose: 93.5 mg/kg (8-18 day pregnant) Reproductive: Other developmental abnormalities

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Delayed effects 		TXAPA9 198,377,2004
oral
mouse 		lowest published toxic dose: 46.75 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Tumorigenic effects: Ovarian tumors

Reproductive: Tumorigenic effects: Uterine tumors 		TOXID9 66,84,2002
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Other neonatal measures or effects 		TXAPA9 215,295,2006
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 236,7,2007
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 220,284,2007
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Delayed effects CRNGDP 25,133,2004
oral
mouse 		lowest published toxic dose: 93.5 mg/kg (8-18 day pregnant) Reproductive: Tumorigenic effects: Transplacental tumorigenesis CRNGDP 25,133,2004
oral
mouse 		lowest published toxic dose: 187 mg/kg (8-18 day pregnant) Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Biochemical and metabolic 		CNREA8 66,1337,2006
oral
rat 		lowest published toxic dose: 3.67 mg/kg (multigenerations) Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		NETEEC 24,743,2002
oral
rat 		lowest published toxic dose: 0.95 mg/kg (0-18 day pregnant) Reproductive: Other effects to embryo or fetus TOXID9 72,214,2003
oral
rat 		lowest published toxic dose: 61.53 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		NETEEC 24,743,2002
oral
rat 		lowest published toxic dose: 54.78 µg/kg (0-21 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth 		TOLED5 136,65,2002
oral
rat 		lowest published toxic dose: 6 mg/kg (3-22 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth 		TOLED5 128,73,2002
oral
rat 		lowest published toxic dose: 0.6 mg/kg (3-22 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Behavioral 		TOLED5 128,73,2002
oral
rat 		lowest published toxic dose: 0.9 mg/kg (1-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 66,84,2002
oral
rat 		lowest published toxic dose: 41 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		FCTOD7 45,1606,2007
parenteral
mouse 		lowest published toxic dose: 10 mg/kg (8 day pregnant) Reproductive: Other effects to embryo or fetus TSPLS* -,218,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg/3 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TOSCF2 76,271,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 1,078 ng/kg Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		TXAPA9 224,138,2007
intramuscular
mouse 		lethal dose (50 percent kill): 14 mg/kg N/R EXMDA4 (440),312,1978
intraperitoneal
guinea pig 		lethal dose : >1 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		JTEHF8 59,119,2000
intraperitoneal
hamster 		lethal dose : >100 µg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		JTEHF8 59,119,2000
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,170 µg/kg N/R COREAF 257,791,1963
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Blood: Changes in bone marrow not included in above

Blood: Tumors 		EVHPAZ 95,,1991
intraperitoneal
mouse 		lowest published toxic dose: 1.25 mg/kg Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 66,86,2002
intraperitoneal
mouse 		lowest published toxic dose: 4 mg/kg Blood: Other changes

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		TOXID9 66,86,2002
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TOPADD 32,527,2004
intraperitoneal
rat 		lowest published lethal dose: 7 mg/kg N/R JPETAB 58,454,1936
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOLED5 165,257,2006
intravenous
rat 		lowest published lethal dose: 6 mg/kg N/R JPETAB 33,270,1928
intravenous
rat 		lowest published toxic dose: 6 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 200,111,2004
intravenous
rabbit 		lethal dose (50 percent kill): 7,600 µg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair 		TXCYAC 51,213,1988
oral
child 		lowest published toxic dose: 1 mg/kg N/R CTOXAO 10,477,1977
oral
child 		lowest published lethal dose: 2 mg/kg N/R CTOXAO 10,477,1977
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 10 mg/kg N/R FMCHA2 -,C277,1991
oral
man 		lowest published lethal dose: 143 mg/kg Behavioral: Excitement

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory stimulation 		YAKUD5 41,1439,1999
oral
rat 		lethal dose (50 percent kill): 41 mg/kg N/R VCVN5* -,89,1993
oral
rat 		lowest published toxic dose: 0.5 mg/kg Brain and Coverings: Other degenerative changes TOLED5 133,93,2002
oral
rat 		lowest published toxic dose: 41 mg/kg Gastrointestinal: Hypermotility, diarrhea FCTOD7 45,1606,2007
oral
rat 		lowest published lethal dose: 41 mg/kg Gastrointestinal: Hypermotility, diarrhea FCTOD7 45,1606,2007
oral
rabbit 		lowest published lethal dose: 12 mg/kg N/R JPETAB 33,270,1928
subcutaneous
mouse 		lowest published toxic dose: 13.5 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 203,53,2005
subcutaneous
mouse 		lowest published lethal dose: 13.5 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 203,53,2005
subcutaneous
rat 		lowest published lethal dose: 11,999 µg/kg N/R JPETAB 320,994,2007
subcutaneous
rat 		lethal dose : 12,999 µg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		JPETAB 320,994,2007
subcutaneous
rat 		lethal dose (50 percent kill): 13,998 µg/kg N/R JPETAB 320,994,2007
skin
mouse 		lethal dose (50 percent kill): 12 mg/kg N/R VCVN5* -,89,1993
skin
rat 		lethal dose (50 percent kill): 150 mg/kg N/R VCVN5* -,89,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrapleural
mouse 		lowest published toxic dose: 2.4 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* IMM-94004
intrapleural
mouse 		lowest published toxic dose: 1.2 mg/kg/14 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Blood: Microcytosis with or without anemia 		NTPTR* IMM-94004
intrapleural
mouse 		lowest published toxic dose: 0.4 mg/kg/14 day- continuous Immunological Including Allergic: Decrease in cellular immune response NTPTR* IMM-94004
intraperitoneal
mouse 		lowest published toxic dose: 16.8 µg/kg/3 week- intermittent Vascular: Structural changes in vessels TOSCF2 76,271,2003
intraperitoneal
mouse 		lowest published toxic dose: 2 mg/kg/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		TOXID9 78,235,2004
intraperitoneal
rat 		lowest published toxic dose: 17,330 µg/kg/7 day- intermittent Endocrine: Hyperglycemia TXAPA9 55,126,1980
intraperitoneal
rat 		lowest published toxic dose: 116.55 mg/kg/21 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 42,737,2004
intraperitoneal
rat 		lowest published toxic dose: 166.5 mg/kg/30 day- intermittent Liver: Other changes

Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 208,25,2005
intraperitoneal
rat 		lowest published toxic dose: 166.5 mg/kg/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Hypoglycemia 		DCTODJ 27,179,2004
intraperitoneal
rat 		lowest published toxic dose: 166.5 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		DCTODJ 27,179,2004
oral
dog 		lowest published toxic dose: 512 mg/kg/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		FAATDF 13,439,1989
oral
guinea pig 		lowest published toxic dose: 634.67 mg/kg/16 week- continuous Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Blood: Other changes 		JTCTDW 39,675,2001
oral
guinea pig 		lowest published toxic dose: 1,586.67 mg/kg/16 week- continuous Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS 		JTCTDW 39,675,2001
oral
guinea pig 		lowest published toxic dose: 635.04 mg/kg/16 week- continuous Liver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		CTOXAO 39,675,2001
oral
guinea pig 		lowest published toxic dose: 1,590.4 mg/kg/16 week- continuous Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		CTOXAO 39,675,2001
oral
mouse 		lowest published toxic dose: 2,621 mg/kg/26 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes 		IJEBA6 37,147,1999
oral
mouse 		lowest published toxic dose: 7 mg/kg/14 day- intermittent Blood: Changes in bone marrow not included in above TOLED5 109(Suppl 1),55,1999
oral
mouse 		lowest published toxic dose: 75 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold 		TOXID9 54,86,2000
oral
mouse 		lowest published toxic dose: 908 mg/kg/17 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TXCYAC 147,157,2000
oral
mouse 		lowest published toxic dose: 504 mg/kg/48 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		TOSCF2 55,460,2000
oral
mouse 		lowest published toxic dose: 1,120 mg/kg/10 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,214,2003
oral
mouse 		lowest published toxic dose: 1,120 mg/kg/10 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOXID9 72,214,2003
oral
mouse 		lowest published toxic dose: 182 mg/kg/26 week- continuous Skin and Appendages: Tumors TOXID9 44,143,2005
oral
mouse 		lowest published toxic dose: 5 mg/kg/2 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other 		TOXID9 44,29,2005
oral
mouse 		lowest published toxic dose: 75.34 mg/kg/10 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 208,357,2005
oral
mouse 		lowest published toxic dose: 70 µg/kg/5 week- continuous Cardiac: Other changes

Vascular: Other changes 		TOXID9 44,238,2005
oral
mouse 		lowest published toxic dose: 144,000 µg/kg/12 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 204,18,2005
oral
mouse 		lowest published toxic dose: 2,520 mg/kg/48 week- continuous Liver: Other changes TOXID9 66,85,2002
oral
mouse 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 78,233,2004
oral
mouse 		lowest published toxic dose: 406 mg/kg/29 week- continuous Skin: After systemic exposure: Dermatitis, other

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 78,390,2004
oral
mouse 		lowest published toxic dose: 116.5 mg/kg/0.5 year- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXAPA9 206,169,2005
oral
mouse 		lowest published toxic dose: 233 mg/kg/1 year- continuous Liver: Fatty liver degeneration TXAPA9 206,169,2005
oral
mouse 		lowest published toxic dose: 292.5 mg/kg/457 day- continuous Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) TXAPA9 206,169,2005
oral
mouse 		lowest published toxic dose: 42 µg/kg/21 day- continuous Kidney, Ureter, and Bladder: Changes primarily in glomeruli TXAPA9 224,39,2007
oral
mouse 		lowest published toxic dose: 6 µg/kg/3 day- continuous Kidney, Ureter, and Bladder: Proteinuria TXAPA9 224,39,2007
oral
mouse 		lowest published toxic dose: 700 µg/kg/2 week- continuous Vascular: Structural changes in vessels

Liver: Other changes 		TXAPA9 222,327,2007
oral
mouse 		lowest published toxic dose: 1,750 µg/kg/5 week- continuous Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXAPA9 222,327,2007
oral
mouse 		lowest published toxic dose: 212,128 mg/kg/8 week- continuous Behavioral: Fluid intake TXAPA9 222,305,2007
oral
mouse 		lowest published toxic dose: 280,672 mg/kg/8 week- continuous Endocrine: Other changes TXAPA9 222,305,2007
oral
mouse 		lowest published toxic dose: 6 mg/kg/3 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 220,146,2007
oral
mouse 		lowest published toxic dose: 12 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TXAPA9 220,146,2007
oral
mouse 		lowest published toxic dose: 16 mg/kg/2 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 220,146,2007
oral
mouse 		lowest published toxic dose: 401.5 mg/kg/365 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		HETOEA 23,399,2004
oral
mouse 		lowest published toxic dose: 60 mg/kg/30 day- continuous Blood: Other changes

Biochemical: Metabolism (intermediary): Other 		TXCYAC 241,134,2007
oral
mouse 		lowest published toxic dose: 1,989.4 mg/kg/29 week- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 226,128,2008
oral
mouse 		lowest published toxic dose: 4,000 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXAPA9 227,108,2008
oral
mouse 		lowest published toxic dose: 0.476 mg/kg/4 week- continuous Nutritional and Gross Metabolic: Other changes TXAPA9 227,400,2008
oral
mouse 		lowest published toxic dose: 0.3 mg/kg/30 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response 		TXAPA9 230,216,2008
oral
rat 		lowest published toxic dose: 2,730 mg/kg/78 week- continuous Cardiac: Cardiac output

Vascular: Measurement of regional blood flow

Vascular: Other changes 		ATSUDG 8,452,1985
oral
rat 		lowest published toxic dose: 560 µg/kg/28 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight 		JTSCDR 24,425,1999
oral
rat 		lowest published toxic dose: 350 mg/kg/16 week- continuous Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Blood: Other changes 		JTCTDW 39,675,2001
oral
rat 		lowest published toxic dose: 875 mg/kg/16 week- continuous Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTCTDW 39,675,2001
oral
rat 		lowest published toxic dose: 187.6 µg/kg/28 day- intermittent Endocrine: Change in gonadotropins

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in ovarian weight 		AECTCV 41,83,2001
oral
rat 		lowest published toxic dose: 372.4 mg/kg/4 week- intermittent Blood: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Liver: Changes in liver weight 		TXCYAC 172,59,2002
oral
rat 		lowest published toxic dose: 2.8 mg/kg/4 week- intermittent Blood: Change in clotting factors TXAPA9 179,83,2002
oral
rat 		lowest published toxic dose: 1,400 mg/kg/16 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		CTOXAO 39,675,2001
oral
rat 		lowest published toxic dose: 560 mg/kg/16 week- continuous Liver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		CTOXAO 39,675,2001
oral
rat 		lowest published toxic dose: 45 mg/kg/90 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 72,271,2003
oral
rat 		lowest published toxic dose: 1.4 mg/kg/28 day- intermittent Endocrine: Change in gonadotropins

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Related to Chronic Data: Changes in ovarian weight 		AECTCV 41,83,2001
oral
rat 		lowest published toxic dose: 0.6 mg/kg/20 day- continuous Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay) 		TOLED5 128,73,2002
oral
rat 		lowest published toxic dose: 266 mg/kg/28 day- intermittent Liver: Changes in liver weight INIMP* 1,925,2001
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 44,124,2005
oral
rat 		lowest published toxic dose: 600 mg/kg/60 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 210,25,2005
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOLED5 156,297,2005
oral
rat 		lowest published toxic dose: 240 mg/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 44,432,2005
oral
rat 		lowest published toxic dose: 120 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor 		TOXID9 44,432,2005
oral
rat 		lowest published toxic dose: 120 mg/kg/30 day- intermittent Gastrointestinal: Other changes

Liver: Other changes

Liver: Changes in liver weight 		TOXID9 44,432,2005
oral
rat 		lowest published toxic dose: 120 mg/kg/30 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		TOXID9 44,432,2005
oral
rat 		lowest published toxic dose: 7 mg/kg/7 day- intermittent Behavioral: Food intake (animal) TOXID9 44,432,2005
oral
rat 		lowest published toxic dose: 204 mg/kg/60 day- intermittent Endocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 78,236,2004
oral
rat 		lowest published toxic dose: 84 mg/kg/12 week- intermittent Spinal Cord: Other degenerative changes NRTXDN 26,309,2005
oral
rat 		lowest published toxic dose: 126 mg/kg/12 week- intermittent Spinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		NRTXDN 26,309,2005
oral
rat 		lowest published toxic dose: 42 mg/kg/12 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 211,26,2005
oral
rat 		lowest published toxic dose: 0.3 mg/kg/60 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 217,63,2006
oral
rat 		lowest published toxic dose: 15 mg/kg/60 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 217,63,2006
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 160,1,2005
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 90,368,2006
oral
rat 		: 7 mg/kg/10 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,1579,2006
oral
rat 		: 2.8 mg/kg/4 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		FCTOD7 44,1579,2006
oral
rat 		: 88.228 mg(As)/kg/4 week- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		JAPTO* 26,213,2006
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOLED5 160,1,2005
oral
rat 		lowest published toxic dose: 153 mg/kg/90 day- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 160,135,2006
oral
rat 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Other 		NRTXDN 27,1024,2006
oral
rat 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NRTXDN 27,1024,2006
oral
rat 		lowest published toxic dose: 25 mg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Endocrine: Hypoglycemia

Blood: Changes in leukocyte (WBC) count 		FCTOD7 46,740,2008
oral
rat 		lowest published toxic dose: 400 mg/kg/80 day- continuous Vascular: BP elevation not characterized in autonomic section FCTOD7 45,2479,2007
oral
rat 		lowest published toxic dose: 1,000 mg/kg/200 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		FCTOD7 45,2479,2007
oral
rat 		lowest published toxic dose: 200 mg/kg/40 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes FCTOD7 45,2479,2007
oral
rat 		lowest published toxic dose: 600 mg/kg/120 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases FCTOD7 45,2479,2007
oral
rat 		lowest published toxic dose: 2,400 mg/kg/240 day- intermittent Liver: Other changes

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		INJPD2 39,107,2007
oral
rabbit 		lowest published toxic dose: 2,483 mg/kg/43 week- continuous Cardiac: Cardiac output

Cardiac: Other changes

Vascular: Other changes 		ATSUDG 8,452,1985
subcutaneous
mouse 		lowest published toxic dose: 98 mg/kg/15 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOSCF2 55,460,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,100,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,100,1987
TOXICOLOGY REVIEW
PTPAD4 1,189,1976
TOXICOLOGY REVIEW
ENVRAL 16,139,1978
TOXICOLOGY REVIEW
TOLED5 133,17,2002
TOXICOLOGY REVIEW
TOLED5 145,1,2003
TOXICOLOGY REVIEW
CRTXB2 33,215,2003
TOXICOLOGY REVIEW
CRTXB2 34,301,2004
TOXICOLOGY REVIEW
NETEEC 29,425,2007
TOXICOLOGY REVIEW
MUREAV 533,65,2003
TOXICOLOGY REVIEW
MUREAV 533,183,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,293,2008
TOXICOLOGY REVIEW
TXAPA9 233,92,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,160,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84465;
Number of Industries 9;
Total Number of Facilities 339;
Number of Occupations 9;
Total Number of Employees Exposed 2,865
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84465;
Number of Industries 7;
Total Number of Facilities 114;
Number of Occupations 7;
Total Number of Employees Exposed 2,068;
Total Number of Female Employees Exposed 222


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a herbicide, pesticide, inhibitor of corrosion and in production of medicinals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967-
ARPTAF Arkhiv Patologii. Archives of Pathology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.8- 1946-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BDERB*
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXMDA4 International Congress Series--Excerpta Medica. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) No.1- 1952-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INIMP* International Immunopharmacology (http://www.elsevier.com/locate/intimp) V.1- 2001-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
IVTOE4 In Vitro Toxicology: A Journal of Molecular and Cellular Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1986/87-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSYBEC Psychobiology. (Psychonomic Society Inc., 1710 Fortview Road, Austin, TX 78704) V.15- 1987-
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TSPLS*
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Used as a herbicide, pesticide, inhibitor of corrosion and in production of medicinals

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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