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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenious acid, monosodium salt

RTECS #

CG3675000

CAS #

7784-46-5

Updated

December 2013

Molecular Weight

129.91

Molecular Formula

AsO2·Na

Synonyms

Arsenenous acid, sodium salt (9CI)
Arsenite de sodium (French)
Atlas A
Chem Pels C
Chem-Sen 56
Kill-All
Penite
Prodalumnol
Prodalumnol double
Sodanit
Sodium arsenite
Sodium metaarsenite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/human8 µmol/LTIVIEQ 5,353,1991
Cytogenetic Analysislymphocyte/human1 mg/LENMUDM 3,597,1981
Cytogenetic Analysisleukocyte/human1 nmol/LAEMBAP 91,117,1978
Cytogenetic Analysisfibroblast/human1 nmol/LAEMBAP 91,117,1978
Cytogenetic Analysislung/human2900 pmol/LMUREAV 16,332,1972
Cytogenetic Analysislymphocyte/mouse1500 µg/LMUREAV 386,279,1997
Cytogenetic Analysisoral/mouse2500 µg/kgFCTOD7 38,735,2000
Cytogenetic Analysisovary/hamster1 µmol/LENMUDM 4,493,1982
Cytogenetic Analysisembryo/hamster6200 nmol/LCRNGDP 6,1421,1985
Cytogenetic Analysislung/hamster10 µmol/L/24HMUTAEX 17,99,2002
Cytogenetic Analysisliver/mouse125 nmol/L/24WTOXID9 72,215,2003
Cytogenetic Analysisovary/hamster1 mmol/L/30MTXAPA9 201,156,2004
Cytogenetic Analysisoral/mouse140 mg/kg/10WEMMUEG 44,179,2004
Cytogenetic Analysisembryo/hamster4 µmol/L/24HMUREAV 603,111,2006
Cytogenetic Analysislymphocyte/human1 µmol/L/48HMUTAEX 19,223,2004
Cytogenetic Analysisother cell types/mouse20 µmol/L/4HMUREAV 634,40,2007
Cytogenetic Analysislymphocyte/human2.5 µmol/L/66HEMMUEG 42,192,2003
Cytogenetic Analysisother cell types/human0.5 µmol/L/2HMUREAV 674,109,2009
Cytogenetic Analysisother cell types/human0.5 µmol/L/4HMUREAV 674,109,2009
Cytogenetic Analysisother cell types/mouse0.77 µmol/L/10DMUREAV 675,66,2009
DNA Damageoral/rat0.804 gm/kg/30D-continuousHETOEA 26,939,2007
DNA Damageother cell types/human0.1 mmol/l/48HMUREAV 696,21,2010
DNA Damageother cell types/human100 µmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human0.316 mmol/l/48HMUREAV 696,21,2010
DNA Damageliver/human0.1 mmol/l/48HMUREAV 696,21,2010
DNA Damageother cell types/human1 µmol/L/48HMUTAEX 22,403,2007
DNA Damageoral/rat140 mg/kg/28D-continuousTOLED5 190,81,2009
DNA Damageoral/mouse70 µg/kg/7D-continuousFCTOD7 48,1032,2010
DNA Damageoral/rat210 mg/kg/21D- intermittentFCTOD7 48,3398,2010
DNA Damagefibroblast/hamster20 µmol/L/3HMUREAV 741,65,2012
DNA Damageother cell types/human2 µmol/L/4HMUREAV 674,109,2009
DNA Damageother cell types/mammal (species unspecified)250 µg/L/16DCNREA8 67,5239,2007
DNA Damageother cell types/human10 µmol/L/24HTXAPA9 232,41,2008
DNA Damageother cell types/human2 µmol/L/1HMUREAV 615,75,2007
DNA Damageother cell types/mouse100 µmol/L/120MMUREAV 603,121,2006
DNA Damageother cell types/human0.01 mmol/L/30MMUTAEX 19,129,2004
DNA Damage/other fish1 µmol/L/4HEMMUEG 44,83,2004
DNA Damageovary/hamster1 µmol/L/4HEMMUEG 44,83,2004
DNA Damageother cell types/human1 mmol/L/6HTOXID9 44,32,2005
DNA Damagefibroblast/human5 µmol/L/2HMUREAV 498,47,2001
DNA Damageoral/mouse100 mg/kgMUREAV 386,315,1997
DNA Damagelung/human1 µmol/LMUREAV 302,97,1993
DNA Damagelymphocyte/human200 µmol/LEMMUEG 23,299,1994
DNA Damageliver/human1 µmol/LCRNGDP 21,701,2000
DNA inhibitionfibroblast/human50 µmol/LIVTOE4 1,103,1987
DNA inhibitionHeLa cell/human200 µmol/LCRNGDP 13,2389,1992
DNA inhibitionHeLa cell/human5 µmol/L/1HMUREAV 493,31,2001
DNA repair/Escherichia coli63 µg/wellENMUDM 3,429,1981
DNA repair/Bacillus subtilis50 mmol/LMUREAV 31,185,1975
DNA repairlung/human25 µmol/L/24HMUREAV 715,32,2011
DNA repairfibroblast/human5 µmol/L/24HMOCAE8 47,508,2008
micronucleus testoral/mouse2.5 mg/kgFCTOD7 47,2454,2009
micronucleus testovary/hamster31.6 µmol/L/3HMUREAV 724,7,2011
micronucleus testother cell types/human1 µmol/L/3HMUREAV 724,7,2011
micronucleus testlymphocyte/human2 µmol/L/20HMUTAEX 22,255,2007
micronucleus testoral/mouse70 mg/kg/7D- intermittentMUREAV 632,37,2007
micronucleus testfibroblast/hamster20 µmol/L/3HMUREAV 741,65,2012
micronucleus testlymphocyte/human3 µmol/LEMMUEG 13,34,1989
micronucleus testfibroblast/human5 µmol/LMUREAV 440,75,1999
micronucleus testlung/hamster10 µmol/L/6HMUTAEX 17,99,2002
micronucleus testintraperitoneal/mouse5 mg/kgMUREAV 147,290,1985
micronucleus testovary/hamster50 µmol/LMUREAV 319,135,1993
micronucleus testliver/human10 µmol/L/24HMUREAV 514,245,2002
micronucleus testmammary gland/human5 µmol/L/46HEMMUEG 40,236,2002
micronucleus testmammary gland/human10 µmol/L/8HEMMUEG 40,236,2002
micronucleus testlymphocyte/human80 µmol/L/2HEMMUEG 39,323,2002
micronucleus testoral/mouse20 mg/kg/4DEMMUEG 40,71,2002
micronucleus testlymphocyte/mouse80 µmol/L/2HEMMUEG 39,323,2002
micronucleus testlymphocyte/rat40 µmol/L/2HEMMUEG 39,323,2002
micronucleus testlymphocyte/pig80 µmol/L/2HEMMUEG 39,323,2002
micronucleus testlymphocyte/human2 µmol/L/24HEMMUEG 39,323,2002
micronucleus testlymphocyte/mouse8 µmol/L/24HEMMUEG 39,323,2002
micronucleus testlymphocyte/rat2 µmol/L/24HEMMUEG 39,323,2002
micronucleus testlymphocyte/pig8 µmol/L/24HEMMUEG 39,323,2002
micronucleus testlymphocyte/human2 µmol/L/48HEMMUEG 39,323,2002
micronucleus testlymphocyte/mouse4 µmol/L/48HEMMUEG 39,323,2002
micronucleus testlymphocyte/rat4 µmol/L/48HEMMUEG 39,323,2002
micronucleus testovary/hamster1 µmol/L/24HEMMUEG 44,83,2004
micronucleus test/other fish1 µmol/L/48HEMMUEG 44,83,2004
morphological transformAscites tumor/human0.025 µmol/L/6WEMMUEG 41,322,2003
morphological transformembryo/hamster1 µmol/L/48HTXCYAC 203,155,2004
morphological transformembryo/hamster2 µmol/LCRNGDP 6,1421,1985
morphological transformembryo/mouse6 µmol/LCRNGDP 8,803,1987
morphological transformfibroblast/mouse0.01 µmol/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
morphological transformfibroblast/human1 µmol/LCNREA8 47,3815,1987
morphological transformother cell types/mouse0.455 mg/L/72HMUREAV 725,57,2011
morphological transformother cell types/mouse0.025 mg/L/10DMUREAV 725,57,2011
morphological transformembryo/mouse0.32 mg/L/72HMUREAV 702,100,2010
morphological transformfibroblast/mouse0.1 mg/L/10DMUREAV 702,100,2010
mutation in mammalian somatic cellslymphocyte/mouse1500 µg/LJTEHD6 9,367,1982
mutation in mammalian somatic cellsmammary gland/rat500 nmol/L/24WMOCAE8 30,79,2001
mutation in microorganisms/Escherichia coli160 µmol/L (-enzymatic activation step)MUREAV 31,185,1975
mutation in microorganisms/Saccharomyes cerevisiae100 mmol/L (-enzymatic activation step)MUREAV 117,149,1983
other mutation test systemslymphocyte/human770 nmol/LSWEHDO 7,277,1981
other mutation test systemsoral/rat0.804 gm/kg/30D-continuousHETOEA 26,939,2007
other mutation test systemsmultiple/other fish200 µmol/L/24H-continuousEMMUEG 48,658,2007
sex chromosome loss and nondisjunctionlymphocyte/human1 pmol/LMUREAV 334,365,1995
sister chromatid exchangeovary/hamster1 µmol/LENMUDM 4,493,1982
sister chromatid exchangeembryo/hamster800 nmol/LCRNGDP 6,1421,1985
sister chromatid exchangefibroblast/hamster1 mg/LMUREAV 104,141,1982
sister chromatid exchangelymphocyte/human3900 nmol/LSWEHDO 7,277,1981
sister chromatid exchangeovary/hamster1 mmol/L/30MTXAPA9 201,156,2004
sister chromatid exchangeliver/mouse125 nmol/L/24WTOXID9 72,215,2003
specific locus testoral/mouse140 mg/kg/10WEMMUEG 44,179,2004
specific locus testother cell types/hamster23 µmol/L/24HEMMUEG 35,114,2000
specific locus testAscites tumor/human0.1 µmol/L/6WEMMUEG 41,322,2003
specific locus testovary/hamster60 µmol/L/24HMUREAV 602,14,2006
specific locus testother cell types/mouse20 µmol/L/4HMUREAV 634,40,2007
specific locus testparenteral/Drosophila melanogaster770 µmol/LEMMUEG 25,288,1995
specific locus testoral/Drosophila melanogaster8 µmol/LEMMUEG 25,288,1995
specific locus testother cell types/human0.63 mg/L (-enzymatic activation step)MUREAV 695,87,2010
specific locus testother cell types/human0.25 mg/L/16H (-enzymatic activation step)MUREAV 724,76,2011
specific locus testother cell types/human0.31 mg/L/16H (+enzymatic activation step)MUREAV 724,76,2011
Unscheduled DNA Synthesis/Other microorganisms30 µmol/LECREAL 180,161,1989
Unscheduled DNA SynthesisAscites tumor/human0.025 µmol/L/6WEMMUEG 41,322,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 11 mg/kg (7D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 23,66A,1981
intraperitoneal/rat 11 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 23,66A,1981
intraperitoneal/mouse 10 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BECTA6 7,216,1972
intraperitoneal/mouse 10 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BECTA6 7,216,1972
intraperitoneal/mouse 10 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemBECTA6 7,216,1972
intraperitoneal/mouse 10 mg/kg (9D pregnant)Reproductive: Other developmental abnormalitiesEVHPAZ 19,219,1977
intraperitoneal/hamster 5 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 23,40A,1981
intraperitoneal/hamster 5 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BECTA6 29,671,1982
intraperitoneal/mouse 10 mg/kg (8D pregnant)Reproductive: Effects on newborn: Sex ratioBDERE* 67,231,2003
intraperitoneal/rat 7 mg/kg (4-10D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXCYAC 234,10,2007
intraperitoneal/mouse 7.5 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
BDERB* 71,124,2004
intraperitoneal/mouse 7.5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
BDERB* 71,124,2004
intraperitoneal/mouse 7.5 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BDERB* 68,335,2003
intraperitoneal/mouse 2.5 mg/kg (8D pregnant)Reproductive: Other developmental abnormalitiesTXAPA9 250,117,2011
intravenous/hamster 2 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemEXMPA6 34,145,1981
intravenous/hamster 5 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EXMPA6 34,145,1981
oral/rat 3.67 mg/kg (multigenerations)Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NETEEC 24,743,2002
oral/rat 0.95 mg/kg (0-18D pregnant)Reproductive: Other effects to embryo or fetusTOXID9 72,214,2003
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary systemTOXID9 72,214,2003
oral/rat 61.53 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NETEEC 24,743,2002
oral/rat 54.78 µg/kg (0-21D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth
TOLED5 136,65,2002
oral/mouse 6 mg/kg (10D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AECTCV 42,93,2002
oral/rat 6 mg/kg (3-22D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth
TOLED5 128,73,2002
oral/rat 0.6 mg/kg (3-22D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Behavioral
TOLED5 128,73,2002
oral/hamster 5 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 23,40A,1981
oral/hamster 25 mg/kg (12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
BECTA6 29,671,1982
oral/mouse 40 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTJADAB 21,27A,1980
oral/mouse 30 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Physical
PSYBEC 24,227,1996
oral/mouse 45 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BECTA6 26,749,1981
oral/mouse 300 mg/kg (15D prior to copulation/1-15D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemARPTAF 57(2),52,1995
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 220,284,2007
oral/rat 41 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
FCTOD7 45,1606,2007
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Biochemical and metabolic
CNREA8 66,1337,2006
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Delayed effectsCRNGDP 25,133,2004
oral/mouse 93.5 mg/kg (8-18D pregnant)Reproductive: Tumorigenic effects: Transplacental tumorigenesisCRNGDP 25,133,2004
oral/mouse 2.2 mg/kg (8-18D pregnant)Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Delayed effects
TXCYAC 198,31,2004
oral/mouse 93.5 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Tumorigenic effects: Transplacental tumorigenesis
TOXID9 44,30,2005
oral/mouse 75.35 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic
TXCYAC 208,357,2005
oral/mouse 93.5 mg/kg (8-18D pregnant)Reproductive: Other developmental abnormalities

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Delayed effects
TXAPA9 198,377,2004
oral/rat 0.9 mg/kg (1-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 66,84,2002
oral/mouse 46.75 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Tumorigenic effects: Ovarian tumors

Reproductive: Tumorigenic effects: Uterine tumors
TOXID9 66,84,2002
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Reproductive: Effects on newborn: Other neonatal measures or effects
TXAPA9 215,295,2006
oral/mouse 187 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 236,7,2007
oral/rat 56.4 mg/kg (1D preg-17W after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
TXCYAC 261,68,2009
oral/rat 26 mg/kg (10D male/10D pre-4W after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
NRTXDN 31,94,2010
oral/rat 444 mg/kg (10D male/10D pre-13W after birth)Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
NRTXDN 31,94,2010
oral/rat 140 mg/kg (28D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesTOLED5 190,81,2009
parenteral/mouse 10 mg/kg (8D pregnant)Reproductive: Other effects to embryo or fetusTSPLS* -,218,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 3 mg/kg/3W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens
TOSCF2 76,271,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 6 µmol/L/48HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTXAPA9 244,366,2010
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 6 µmol/L/96HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Other assays
TXAPA9 244,366,2010
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 25 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Human, lung Inhibitor Concentration Low: 20 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 273,12,2010
In Vitro/Human, lung Inhibitor Concentration Low: 200 nmol/LIn Vitro Toxicity Studies: Other assaysTXCYAC 273,12,2010
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 10 µmol/L/12HIn Vitro Toxicity Studies: Other assays

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 249,86,2010
In Vitro/jkhInhibitor Concentration (50 percent kill): 30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/jtiInhibitor Concentration Low: 0.1 µmol/L/12HVascular: Other changesTXAPA9 244,291,2010
In Vitro/jtiInhibitor Concentration Low: 0.5 µmol/L/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTXAPA9 244,291,2010
In Vitro/jtiInhibitor Concentration Low: 0.05 µmol/L/8HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTXAPA9 244,291,2010
In Vitro/mqbInhibitor Concentration Low: 20 nmol/L/3DIn Vitro Toxicity Studies: Cell differentiationTXAPA9 250,154,2011
In Vitro/mzxInhibitor Concentration Low: 0.5 µmol/L/4DImmunological Including Allergic: Decrease in humoral immune responseTXAPA9 245,344,2010
In Vitro/mzxInhibitor Concentration Low: 5 µmol/L/8HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,344,2010
In Vitro/paaInhibitor Concentration (50 percent kill): 25 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 150 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
intracerebral/rat lowest published toxic dose: 1078 ng/kgBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TXAPA9 224,138,2007
intramuscular/mouse lethal dose (50 percent kill): 14 mg/kgEXMDA4 (440),312,1978
intraperitoneal/guinea pig Lethal dose: >1 mg/kgKidney, Ureter, and Bladder: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JTEHF8 59,119,2000
intraperitoneal/hamster Lethal dose: >100 µg/kgKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JTEHF8 59,119,2000
intraperitoneal/mouse lethal dose (50 percent kill): 1170 µg/kgCOREAF 257,791,1963
intraperitoneal/mouse lowest published toxic dose: 10 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOPADD 32,527,2004
intraperitoneal/mouse lowest published toxic dose: 4 mg/kgBlood: Other changes

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
TOXID9 66,86,2002
intraperitoneal/mouse lowest published toxic dose: 4 mg/kgLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BCLPT* 100,249,2007
intraperitoneal/mouse lowest published toxic dose: 2.5 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 47,2454,2009
intraperitoneal/mouse lowest published toxic dose: 10 mg/kgBlood: Changes in bone marrow not included in above

Blood: Tumors
EVHPAZ 95,,1991
intraperitoneal/mouse lowest published toxic dose: 1.25 mg/kgLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 66,86,2002
intraperitoneal/rat lowest published toxic dose: 3 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 165,257,2006
intraperitoneal/rat lowest published lethal dose: 7 mg/kgJPETAB 58,454,1936
intravenous/rabbit lethal dose (50 percent kill): 7600 µg/kgBehavioral: Change in motor activity (specific assay)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
TXCYAC 51,213,1988
intravenous/rat lowest published lethal dose: 6 mg/kgJPETAB 33,270,1928
intravenous/rat lowest published toxic dose: 2 mg(As)/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TXAPA9 232,33,2008
intravenous/rat lowest published toxic dose: 6 mg/kgKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 200,111,2004
oral/child lowest published toxic dose: 1 mg/kgCTOXAO 10,477,1977
oral/child lowest published lethal dose: 2 mg/kgCTOXAO 10,477,1977
oral/mammal (species unspecified) lethal dose (50 percent kill): 10 mg/kgFMCHA2 -,C277,1991
oral/man lowest published lethal dose: 143 mg/kgBehavioral: Excitement

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory stimulation
YAKUD5 41,1439,1999
oral/mouse lowest published toxic dose: 36 mg/kgBehavioral: Alteration of classical conditioning

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed
JOETD7 134,26,2011
oral/rabbit lowest published lethal dose: 12 mg/kgJPETAB 33,270,1928
oral/rat lowest published toxic dose: 41 mg/kgGastrointestinal: Hypermotility, diarrheaFCTOD7 45,1606,2007
oral/rat lethal dose (50 percent kill): 41 mg/kgVCVN5* -,89,1993
oral/rat lowest published lethal dose: 41 mg/kgGastrointestinal: Hypermotility, diarrheaFCTOD7 45,1606,2007
oral/rat lowest published toxic dose: 8 mg/kgReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 187,201,2009
oral/rat lowest published toxic dose: 0.5 mg/kgBrain and Coverings: Other degenerative changesTOLED5 133,93,2002
skin/mouse lethal dose (50 percent kill): 12 mg/kgVCVN5* -,89,1993
skin/rat lethal dose (50 percent kill): 150 mg/kgVCVN5* -,89,1993
subcutaneous/mouse lowest published toxic dose: 13.5 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 203,53,2005
subcutaneous/mouse lowest published lethal dose: 13.5 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 203,53,2005
subcutaneous/rat lowest published lethal dose: 11999 µg/kgJPETAB 320,994,2007
subcutaneous/rat lethal dose (50 percent kill): 13998 µg/kgJPETAB 320,994,2007
subcutaneous/rat lowest published lethal dose: 12999 µg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
JPETAB 320,994,2007
Tank with water/other fish lowest published toxic concentration: 25982 µg/L/6HLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
EMMUEG 48,658,2007
Tank with water/other fish lowest published toxic concentration: 12991 µg/L/7DLiver: Other changesEMMUEG 48,558,2007
Tank with water/other fish lowest published toxic concentration: 25982 µg/L/4DLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
EMMUEG 48,558,2007

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 16.8 µg/kg/3W- intermittentVascular: Structural changes in vesselsTOSCF2 76,271,2003
intraperitoneal/mouse lowest published toxic dose: 2 mg/kg/2W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TOXID9 78,235,2004
intraperitoneal/rat lowest published toxic dose: 166.5 mg/kg/30D- intermittentLiver: Other changes

Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 208,25,2005
intraperitoneal/rat lowest published toxic dose: 116.55 mg/kg/21D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 42,737,2004
intraperitoneal/rat lowest published toxic dose: 166.5 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Hypoglycemia
DCTODJ 27,179,2004
intraperitoneal/rat lowest published toxic dose: 166.5 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
DCTODJ 27,179,2004
intraperitoneal/rat lowest published toxic dose: 17330 µg/kg/7D- intermittentEndocrine: HyperglycemiaTXAPA9 55,126,1980
intrapleural/mouse lowest published toxic dose: 2.4 mg/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* IMM-94004
intrapleural/mouse lowest published toxic dose: 1.2 mg/kg/14D- continuousLung, Thorax, or Respiration: Changes in lung weight

Blood: Microcytosis with or without anemia
NTPTR* IMM-94004
intrapleural/mouse lowest published toxic dose: 0.4 mg/kg/14D- continuousImmunological Including Allergic: Decrease in cellular immune responseNTPTR* IMM-94004
oral/chicken lowest published toxic dose: 15 mg/kg/60D- intermittentEndocrine: Changes in spleen weight

Immunological Including Allergic: Decreased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 251,51,2008
oral/Dog lowest published toxic dose: 512 mg/kg/26W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FAATDF 13,439,1989
oral/guinea pig lowest published toxic dose: 634.67 mg/kg/16W- continuousBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Blood: Other changes
JTCTDW 39,675,2001
oral/guinea pig lowest published toxic dose: 1586.67 mg/kg/16W- continuousBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
JTCTDW 39,675,2001
oral/guinea pig lowest published toxic dose: 635.04 mg/kg/16W- continuousLiver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 39,675,2001
oral/guinea pig lowest published toxic dose: 1590.4 mg/kg/16W- continuousBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
JTCTDW 39,675,2001
oral/monkey lowest published toxic dose: 30 mg/kg/6D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 -,329,2009
oral/mouse lowest published toxic dose: 28 µg/kg/2W- continuousLiver: Other changesJCINAO 118,3980,2008
oral/mouse lowest published toxic dose: 100 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 -,137,2009
oral/mouse lowest published toxic dose: 10.92 mg/kg/13W- continuousBlood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,267,2009
oral/mouse lowest published toxic dose: 75 mg/kg/30D- intermittentLiver: Other changesTOXID9 -,327,2009
oral/mouse lowest published toxic dose: 60 mg/kg/30D- continuousBlood: Other changes

Biochemical: Metabolism (intermediary): Other
TXCYAC 241,134,2007
oral/mouse lowest published toxic dose: 1989.4 mg/kg/29W- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 226,128,2008
oral/mouse lowest published toxic dose: 116.5 mg/kg/0.5Y- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 206,169,2005
oral/mouse lowest published toxic dose: 233 mg/kg/1Y- continuousLiver: Fatty liver degenerationTXAPA9 206,169,2005
oral/mouse lowest published toxic dose: 292.5 mg/kg/457D- continuousLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)TXAPA9 206,169,2005
oral/mouse lowest published toxic dose: 0.476 mg/kg/4W- continuousNutritional and Gross Metabolic: Other changesTXAPA9 227,400,2008
oral/mouse lowest published toxic dose: 0.3 mg/kg/30D- intermittentBlood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TXAPA9 230,216,2008
oral/mouse lowest published toxic dose: 20 mg/kg/2D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BCLPT* 101,333,2007
oral/mouse lowest published toxic dose: 20 mg/kg/2D- intermittentCardiac: Cardiomyopathy including infarction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 82,137,2008
oral/mouse lowest published toxic dose: 1.041 gm/kg/7W- continuousVascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 241,90,2009
oral/mouse lowest published toxic dose: 31.58 mg/kg/13W- continuousVascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 241,90,2009
oral/mouse lowest published toxic dose: 3.927 gm/kg/33W- continuousVascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 241,90,2009
oral/mouse lowest published toxic dose: 1.428 gm/kg/12W- continuousVascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 241,90,2009
oral/mouse lowest published toxic dose: 700 µg/kg/7D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,1032,2010
oral/mouse lowest published toxic dose: 70 µg/kg/5W- continuousCardiac: Other changes

Vascular: Other changes
TOXID9 44,238,2005
oral/mouse lowest published toxic dose: 144000 µg/kg/12W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 204,18,2005
oral/mouse lowest published toxic dose: 2621 mg/kg/26W- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes
IJEBA6 37,147,1999
oral/mouse lowest published toxic dose: 7 mg/kg/14D- intermittentBlood: Changes in bone marrow not included in aboveTOLED5 109(Suppl 1),55,1999
oral/mouse lowest published toxic dose: 75 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold
TOXID9 54,86,2000
oral/mouse lowest published toxic dose: 908 mg/kg/17W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXCYAC 147,157,2000
oral/mouse lowest published toxic dose: 504 mg/kg/48W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TOSCF2 55,460,2000
oral/mouse lowest published toxic dose: 1120 mg/kg/10W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 72,214,2003
oral/mouse lowest published toxic dose: 1120 mg/kg/10W- continuousLiver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TOXID9 72,214,2003
oral/mouse lowest published toxic dose: 75.34 mg/kg/10D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 208,357,2005
oral/mouse lowest published toxic dose: 42 µg/kg/21D- continuousKidney, Ureter, and Bladder: Changes primarily in glomeruliTXAPA9 224,39,2007
oral/mouse lowest published toxic dose: 6 µg/kg/3D- continuousKidney, Ureter, and Bladder: ProteinuriaTXAPA9 224,39,2007
oral/mouse lowest published toxic dose: 700 µg/kg/2W- continuousVascular: Structural changes in vessels

Liver: Other changes
TXAPA9 222,327,2007
oral/mouse lowest published toxic dose: 1750 µg/kg/5W- continuousBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 222,327,2007
oral/mouse lowest published toxic dose: 212128 mg/kg/8W- continuousBehavioral: Fluid intakeTXAPA9 222,305,2007
oral/mouse lowest published toxic dose: 280672 mg/kg/8W- continuousEndocrine: Other changesTXAPA9 222,305,2007
oral/mouse lowest published toxic dose: 6 mg/kg/3D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 220,146,2007
oral/mouse lowest published toxic dose: 12 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTXAPA9 220,146,2007
oral/mouse lowest published toxic dose: 16 mg/kg/2D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 220,146,2007
oral/mouse lowest published toxic dose: 401.5 mg/kg/365D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
HETOEA 23,399,2004
oral/mouse lowest published toxic dose: 2520 mg/kg/48W- continuousLiver: Other changesTOXID9 66,85,2002
oral/mouse lowest published toxic dose: 100 mg/kg/10D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 78,233,2004
oral/mouse lowest published toxic dose: 182 mg/kg/26W- continuousSkin and Appendages: TumorsTOXID9 44,143,2005
oral/mouse lowest published toxic dose: 5 mg/kg/2D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TOXID9 44,29,2005
oral/mouse lowest published toxic dose: 406 mg/kg/29W- continuousSkin: After systemic exposure: Dermatitis, other

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,390,2004
oral/mouse lowest published toxic dose: 80 mg/kg/8D- continuousBehavioral: Tremor

Behavioral: Alteration of classical conditioning

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 246,1,2010
oral/mouse lowest published toxic dose: 108 mg/kg/6D- continuousBehavioral: Tremor

Behavioral: Alteration of classical conditioning

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 246,1,2010
oral/mouse lowest published toxic dose: 76 mg/kg/7D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 246,1,2010
oral/mouse lowest published toxic dose: 84 mg/kg/9D- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Blood: Changes in spleen
TXAPA9 246,1,2010
oral/rabbit lowest published toxic dose: 2483 mg/kg/43W- continuousCardiac: Cardiac output

Cardiac: Other changes

Vascular: Other changes
ATSUDG 8,452,1985
oral/rat lowest published toxic dose: 2730 mg/kg/78W- continuousCardiac: Cardiac output

Vascular: Measurement of regional blood flow

Vascular: Other changes
ATSUDG 8,452,1985
oral/rat lowest published toxic dose: 560 µg/kg/28D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
JTSCDR 24,425,1999
oral/rat lowest published toxic dose: 372.4 mg/kg/4W- intermittentBlood: Other changes

Immunological Including Allergic: Decrease in humoral immune response

Liver: Changes in liver weight
TXCYAC 172,59,2002
oral/rat lowest published toxic dose: 2.8 mg/kg/4W- intermittentBlood: Change in clotting factorsTXAPA9 179,83,2002
oral/rat lowest published toxic dose: 1400 mg/kg/16W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
JTCTDW 39,675,2001
oral/rat lowest published toxic dose: 560 mg/kg/16W- continuousLiver: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 39,675,2001
oral/rat lowest published toxic dose: 350 mg/kg/16W- continuousBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Blood: Other changes
JTCTDW 39,675,2001
oral/rat lowest published toxic dose: 875 mg/kg/16W- continuousBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JTCTDW 39,675,2001
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 156,297,2005
oral/rat lowest published toxic dose: 240 mg/kg/30D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 44,432,2005
oral/rat lowest published toxic dose: 120 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor
TOXID9 44,432,2005
oral/rat lowest published toxic dose: 120 mg/kg/30D- intermittentGastrointestinal: Other changes

Liver: Other changes

Liver: Changes in liver weight
TOXID9 44,432,2005
oral/rat lowest published toxic dose: 120 mg/kg/30D- intermittentBlood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
TOXID9 44,432,2005
oral/rat lowest published toxic dose: 7 mg/kg/7D- intermittentBehavioral: Food intake (animal)TOXID9 44,432,2005
oral/rat lowest published toxic dose: 45 mg/kg/90D- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,271,2003
oral/rat lowest published toxic dose: 1.4 mg/kg/28D- intermittentEndocrine: Change in gonadotropins

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Related to Chronic Data: Changes in ovarian weight
AECTCV 41,83,2001
oral/rat lowest published toxic dose: 187.6 µg/kg/28D- intermittentEndocrine: Change in gonadotropins

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in ovarian weight
AECTCV 41,83,2001
oral/rat lowest published toxic dose: 0.6 mg/kg/20D- continuousBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)
TOLED5 128,73,2002
oral/rat lowest published toxic dose: 84 mg/kg/12W- intermittentSpinal Cord: Other degenerative changesNRTXDN 26,309,2005
oral/rat lowest published toxic dose: 126 mg/kg/12W- intermittentSpinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
NRTXDN 26,309,2005
oral/rat lowest published toxic dose: 42 mg/kg/12W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 211,26,2005
oral/rat lowest published toxic dose: 0.3 mg/kg/60D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 217,63,2006
oral/rat lowest published toxic dose: 15 mg/kg/60D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 217,63,2006
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 160,1,2005
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,368,2006
oral/rat lowest published toxic dose: 266 mg/kg/28D- intermittentLiver: Changes in liver weightINIMP* 1,925,2001
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 44,124,2005
oral/rat lowest published toxic dose: 300 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
NRTXDN 27,1024,2006
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 27,1024,2006
oral/rat lowest published toxic dose: 600 mg/kg/60D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 210,25,2005
oral/rat lowest published toxic dose: 204 mg/kg/60D- intermittentEndocrine: Hyperglycemia

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 78,236,2004
oral/rat : 7 mg/kg/10W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 44,1579,2006
oral/rat : 2.8 mg/kg/4W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 44,1579,2006
oral/rat : 88.228 mg(As)/kg/4W- continuousBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
JAPTO* 26,213,2006
oral/rat lowest published toxic dose: 0.168 gm/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 48,1072,2010
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentCardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 48,1210,2010
oral/rat lowest published toxic dose: 210 mg/kg/21D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 48,3398,2010
oral/rat lowest published toxic dose: 84.9 mg/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNETEEC 32,640,2010
oral/rat lowest published toxic dose: 948.05 mg/kg/335D- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NETEEC 32,640,2010
oral/rat lowest published toxic dose: 25.795 mg/kg/335D- continuousBehavioral: Fluid intakeNETEEC 32,640,2010
oral/rat lowest published toxic dose: 8.395 mg/kg/1Y- continuousBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)
NETEEC 32,640,2010
oral/rat lowest published toxic dose: 1032.95 mg/kg/1Y- continuousBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 32,640,2010
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentBiochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NRTXDN 31,533,2010
oral/rat lowest published toxic dose: 77.5 mg/kg/31D- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 49,974,2011
oral/rat lowest published toxic dose: 1200 mg/kg/120D- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 284,26,2011
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETOX* 32,760,2011
oral/rat lowest published toxic dose: 375 mg/kg/30D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 244,315,2010
oral/rat lowest published toxic dose: 900 mg/kg/90D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TXAPA9 244,315,2010
oral/rat lowest published toxic dose: 300 mg/kg/30D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 244,315,2010
oral/rat lowest published toxic dose: 600 mg/kg/60D- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 244,315,2010
oral/rat lowest published toxic dose: 10.5 mg/kg/3W- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TXAPA9 240,73,2009
oral/rat lowest published toxic dose: 10.5 mg/kg/1W- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TXAPA9 240,73,2009
oral/rat lowest published toxic dose: 17.5 mg/kg/5W- continuousBehavioral: Food intake (animal)TXAPA9 244,99,2010
oral/rat lowest published toxic dose: 43.75 mg/kg/5W- continuousKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladderTXAPA9 244,99,2010
oral/rat lowest published toxic dose: 87.5 mg/kg/5W- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Kidney, Ureter, and Bladder: Other changes
TXAPA9 244,99,2010
oral/rat lowest published toxic dose: 175 mg/kg/5W- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 244,99,2010
oral/rat lowest published toxic dose: 140 mg/kg/28D- continuousRelated to Chronic Data: Changes in ovarian weightTOLED5 190,81,2009
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
ARTODN 82,543,2008
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 48,326,2010
oral/rat lowest published toxic dose: 70 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,605,2010
oral/rat lowest published toxic dose: 150 mg/kg/15D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 47,2544,2009
oral/rat lowest published toxic dose: 130 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests

Biochemical: Metabolism (intermediary): Other
TXAPA9 240,236,2009
oral/rat lowest published toxic dose: 560 mg/kg/28D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 240,367,2009
oral/rat lowest published toxic dose: 11.9 mg/kg/17W- continuousBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
FCTOD7 47,490,2009
oral/rat lowest published toxic dose: 150 mg/kg/30D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 47,249,2009
oral/rat lowest published toxic dose: 300 mg/kg/30D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 160,1,2005
oral/rat lowest published toxic dose: 153 mg/kg/90D- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 160,135,2006
oral/rat lowest published toxic dose: 25 mg/kg/5D- intermittentBehavioral: Somnolence (general depressed activity)

Endocrine: Hypoglycemia

Blood: Changes in leukocyte (WBC) count
FCTOD7 46,740,2008
oral/rat lowest published toxic dose: 400 mg/kg/80D- continuousVascular: BP elevation not characterized in autonomic sectionFCTOD7 45,2479,2007
oral/rat lowest published toxic dose: 1000 mg/kg/200D- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 45,2479,2007
oral/rat lowest published toxic dose: 200 mg/kg/40D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesFCTOD7 45,2479,2007
oral/rat lowest published toxic dose: 600 mg/kg/120D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: CatalasesFCTOD7 45,2479,2007
oral/rat lowest published toxic dose: 2400 mg/kg/240D- intermittentLiver: Other changes

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
INJPD2 39,107,2007
oral/rat lowest published toxic dose: 285.6 mg/kg/6W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 184,121,2009
oral/rat lowest published toxic dose: 571.2 mg/kg/12W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 184,121,2009
oral/rat lowest published toxic dose: 150 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed
FCTOD7 46,3506,2008
oral/rat lowest published toxic dose: 181.7 mg/kg/3W- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
TXCYAC 261,41,2009
oral/rat lowest published toxic dose: 140 mg/kg/2W- continuousGastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CBINA8 176,188,2008
oral/rat lowest published toxic dose: 84 mg/kg/4W- continuousPeripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Other proteins
CBINA8 176,188,2008
oral/rat lowest published toxic dose: 0.804 gm/kg/30D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins
HETOEA 26,939,2007
oral/rat lowest published toxic dose: 20 mg/kg/2D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TOLED5 187,201,2009
oral/rat lowest published toxic dose: 15 mg/kg/3D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 187,201,2009
oral/rat lowest published toxic dose: 121.1 mg/kg/2W- continuousKidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladderTOLED5 187,124,2009
oral/rat lowest published toxic dose: 600 mg/kg/60D- intermittentBlood: Other changesTXAPA9 250,39,2011
oral/rat lowest published toxic dose: 900 mg/kg/90D- intermittentBlood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 250,39,2011
oral/rat lowest published toxic dose: 1200 mg/kg/120D- intermittentBlood: Other hemolysis with or without anemia

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 250,39,2011
subcutaneous/mouse lowest published toxic dose: 98 mg/kg/15W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 55,460,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,100,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,100,1987
TOXICOLOGY REVIEWPTPAD4 1,189,1976
TOXICOLOGY REVIEWENVRAL 16,139,1978
TOXICOLOGY REVIEWTOLED5 133,17,2002
TOXICOLOGY REVIEWTOLED5 145,1,2003
TOXICOLOGY REVIEWCRTXB2 33,215,2003
TOXICOLOGY REVIEWCRTXB2 34,301,2004
TOXICOLOGY REVIEWNETEEC 29,425,2007
TOXICOLOGY REVIEWMUREAV 533,65,2003
TOXICOLOGY REVIEWMUREAV 533,183,2003
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUREAV 659,293,2008
TOXICOLOGY REVIEWTXAPA9 233,92,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWAEXHE* -,397,1999
TOXICOLOGY REVIEWMUTAEX 22,161,2007
TOXICOLOGY REVIEWIMEMDT 84,156,
TOXICOLOGY REVIEWMUREAV 704,115,2010
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 714,105,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 751,15,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,160,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(As)/m3, NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84465; Number of Industries 7; Total Number of Facilities 114; Number of Occupations 7; Total Number of Employees Exposed 2068; Total Number of Female Employees Exposed 222
National Occupational Hazard Survey 1974Hazard Code 84465; Number of Industries 9; Total Number of Facilities 339; Number of Occupations 9; Total Number of Employees Exposed 2865

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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