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Arsenic trioxide

RTECS #: CG3325000

CAS #: 1327-53-3


UPDATE: May 2009 MW: 197.84 MF: As2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acide arsenieux (French)
  2. Anhydride arsenieux (French)
  3. Arsenic blanc (French)
  4. Arsenic sesquioxide
  5. Arsenic oxide
  6. Arsenic (III) oxide
  7. Arsenic trioxide (ACGIH)
  8. Arsenicum album
  9. Arsenigen saure (German)
  10. Arsenious acid
  11. Arsenious oxide
  12. Arsenious trioxide
  13. Arsenite
  14. Arsenolite
  1. Arsenous acid
  2. Arsenous anhydride
  3. Arsenous oxide
  4. Arsenous oxide anhydride
  5. Arsenous acid anhydride
  6. Arsentrioxide
  7. Arsodent
  8. Claudelite
  9. Claudetite
  10. Crude arsenic
  11. Diarsenic trioxide
  12. RCRA waste number P012
  13. White arsenic


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human leukocyte 1,200 nmol/L MUREAV 88,73,1981
cytogenetic analysis oral
mouse
3,696 mg/kg CYTOAN 52,445,1987
cytogenetic analysis mouse other cell types 28,500 g/m3 JJATDK 5,61,1985
cytogenetic analysis mouse other cell types 7 mol/L/4 hour MUREAV 634,40,2007
cytogenetic analysis intraperitoneal
rat
25 mg/kg/5 day- intermittent MUREAV 587,126,2005
cytogenetic analysis intraperitoneal
rat
25 mg/kg/5 day TOXID9 78,390,2004
DNA damage human fibroblast 5 g/L/30 minute TOXID9 66,123,2002
DNA damage human other cell types 5 g/L/30 minute TOXID9 66,123,2002
DNA damage oral
mouse
0.13 mg/kg TXCYAC 162,171,2001
DNA inhibition human HeLa cell 500 mol/L MUREAV 92,427,1982
DNA inhibition oral
mouse
20 mL/kg ARGEAR 51,605,1981
DNA repair Bacillus subtilis 50 mmol/L MUREAV 77,109,1980
unscheduled DNA synthesis human lung 1 mol/L MUREAV 315,11,1994
mutation in microorganisms Saccharomyes cerevisiae 125 mg/L/18 hour (+/-enzymatic activation step) MUREAV 653,63,2008
micronucleus test hamster lung 250 nmol/L MUREAV 412,213,1998
micronucleus test human liver 5 mol/L/24 hour TXCYAC 198,315,2004
micronucleus test intraperitoneal
mouse
1 mg/kg GNKAA5 20,365,1984
micronucleus test intraperitoneal
rat
50 mg/kg/5 day- intermittent MUREAV 587,126,2005
micronucleus test intraperitoneal
rat
50 mg/kg/5 day MUREAV 577S,1,2005
morphological transform mouse other cell types 0.4 mg/L/12 day MUREAV 557,191,2004
sister chromatid exchange human lymphocyte 2 g/cm3 BCTKAG 19,255,1986
specific locus test intraperitoneal
mouse
38 mg/kg/5 day MUREAV 513,205,2002
specific locus test mouse other cell types 7 mol/L/4 hour MUREAV 634,40,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 28,500 g/m3/4 hour (9-12 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 5,61,1985
inhalation
mouse
lowest published toxic concentration: 260 g/m3/4 hour (9-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JJATDK 5,61,1985
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 60,283,1999
intratracheal
rat
lowest published toxic dose: 20,800 g/kg (8 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NEZAAQ 50,135,1995
oral
mouse
lowest published toxic dose: 224 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) AEHLAU 23,102,1971
oral
mouse
lowest published toxic dose: 3,636 mg/kg (1-18 day pregnant) Reproductive: Effects on fertility: Abortion 52GUAX -,91,1983
oral
mouse
lowest published toxic dose: 8,250 g/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Behavioral
CHYCDW 28,20,1994
oral
mouse
lowest published toxic dose: 1,650 g/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system CHYCDW 28,20,1994
oral
mouse
lowest published toxic dose: 315 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72,35,2003
oral
rat
lowest published toxic dose: 30 mg/kg (9 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TJADAB 60,283,1999
oral
rat
lowest published toxic dose: 330 mg/kg (14 day prior to copulation/1-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 38,459,2000
oral
rat
lowest published toxic dose: 0.756 mg/kg (1-18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 44,30,2005
oral
woman
lowest published toxic dose: 600 mg/kg (30 week pregnant) Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects
AJDCAI 117,328,1969


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 50 g/m3/24 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
HBPTO* 2,1398,2001
intratracheal
hamster
lowest published toxic dose: 45 mg/kg/15 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ATSUDG 7,403,1984
intratracheal
hamster
toxic dose : 40 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
intratracheal
hamster
toxic dose : 55,450 g/kg/15 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
intratracheal
hamster
toxic dose : 39,608 g/kg/24 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
intratracheal
hamster
toxic dose : 55,456 g/kg/24 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
intratracheal
hamster
toxic dose : 30 mg/kg/15 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SAIGBL 24,523,1982
intratracheal
rat
lowest published toxic dose: 16 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
EVHPAZ 19,191,1977
intratracheal
rat
toxic dose : 75 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FKIZA4 71,19,1980
intratracheal
rat
toxic dose : 167 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SAIGBL 20,230,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intradermal
chicken
lowest published lethal dose: 13 mg/kg N/R HBAMAK 4,1306,1935
intradermal
dog
lowest published lethal dose: 2 mg/kg N/R HBAMAK 4,1306,1935
intradermal
pigeon
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1306,1935
intraperitoneal
mouse
lethal dose (50 percent kill): 10 mg/kg N/R VCVN5* -,88,1993
intraperitoneal
rat
lethal dose (50 percent kill): 871 mg/kg N/R GTPZAB 19(3),30,1975
intravenous
guinea pig
lowest published toxic dose: 0.8 mg/kg Cardiac: EKG changes not diagnostic of above

Cardiac: Change in resting or action potential
BCLPT* 98,381,2006
intravenous
mouse
lethal dose (50 percent kill): 10,700 g/kg N/R PSEBAA 78,392,1951
intravenous
rat
lowest published toxic dose: 3.96 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 66,83,2002
intravenous
rabbit
lowest published lethal dose: 10,560 g/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes
BIZEA2 70,144,1915
oral
cattle
lowest published lethal dose: 30 mg/kg N/R HBAMAK 4,1306,1935
oral
dog
lowest published lethal dose: 10 mg/kg N/R HBAMAK 4,1306,1935
oral
human
lowest published lethal dose: 1,429 g/kg N/R YKYUA6 31,1247,1980
oral
human
lowest published lethal dose: 1.1 mg/kg Gastrointestinal: Nausea or vomiting

Behavioral: Headache

Vascular: BP lowering not characterized in autonomic section
BJDEAZ 149,757,2003
oral
man
lowest published lethal dose: 114 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
HETOEA 18,640,1999
oral
man
lowest published lethal dose: 29 mg/kg Behavioral: Sleep

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea
AEMED3 16,702,1987
oral
man
lowest published lethal dose: 286 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Liver: Liver function tests impaired

Musculoskeletal: Other changes
JTCTDW 29,45,1991
oral
man
lowest published toxic dose: 14,857 g/kg Eye: Visual field changes

Gastrointestinal: Hypermotility, diarrhea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTCTDW 36,27,1998
oral
man
lowest published lethal dose: 2,857 mg/kg Behavioral: Coma

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 29,131,1991
oral
man
lowest published lethal dose: 123 mg/kg Brain and Coverings: Other degenerative changes

Gastrointestinal: Nausea or vomiting

Liver: Other changes
JFSCAS 36,1163,1992
oral
man
lowest published toxic dose: 2 mg/kg Behavioral: Headache

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting
JTCTDW 39,13,2001
oral
man
lowest published toxic dose: 8.6 mg/kg Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
ARTODN 77,63,2003
oral
man
lowest published toxic dose: 143 mg/kg Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting
HETOEA 23,359,2004
oral
man
lowest published lethal dose: 142.8 mg/kg Brain and Coverings: Changes in circulation

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 41,1,2003
oral
mouse
lethal dose (50 percent kill): 20 mg/kg N/R VCVN5* -,88,1993
oral
rat
lethal dose (50 percent kill): 10 mg/kg N/R VCVN5* -,88,1993
oral
rabbit
lethal dose (50 percent kill): 20,190 g/kg N/R CHYCDW 22,284,1988
oral
woman
lowest published toxic dose: 100 mg/kg Cardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
oral
woman
lowest published toxic dose: 549 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting

Blood: Changes in bone marrow not included in above
JJAMA* 20,1557,1996
oral
woman
lowest published toxic dose: 20 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes

Liver: Other changes
IAEHDW 68,342,1996
oral
woman
lowest published toxic dose: 100 mg/kg Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
JTCTDW 38,471,2000
oral
woman
lowest published toxic dose: 0.1 gm/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
oral
woman
lowest published toxic dose: 180 mg/kg Peripheral Nerve and Sensation: Paresthesia

Cardiac: EKG changes not diagnostic of above

Liver: Liver function tests impaired
JTCTDW 42,889,2004
subcutaneous
mouse
lethal dose (50 percent kill): 9,800 g/kg N/R PSEBAA 78,392,1951
subcutaneous
rat
lowest published lethal dose: 8 mg/kg Skin: After topical application: Corrosive JPETAB 19,337,1922
unreported route
human
lowest published lethal dose: 0.29 mg/kg N/R VCVN5* -,92,1993
unreported route
man
lowest published lethal dose: 2,941 g/kg N/R 85DCAI 2,73,1970
unreported route
rat
lowest published lethal dose: 8 mg/kg N/R BIZEA2 184,360,1927


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 31 g/m3/24 hour/22 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 47(1),6,1982
inhalation
rat
lowest published toxic concentration: 500 g/m3/24 hour/33 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(11),74,1982
inhalation
rabbit
lowest published toxic concentration: 0.22 mg/m3/8 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 66,83,2002
intraperitoneal
rat
lowest published toxic dose: 25 mg/kg/5 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 44,379,2005
intratracheal
hamster
lowest published toxic dose: 20,800 g/kg/8 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
FKIZA4 91,21,2000
intratracheal
rat
lowest published toxic dose: 20,800 g/kg/8 week- intermittent Liver: Changes in liver weight NEZAAQ 50,133,1995
intravenous
rabbit
lowest published toxic dose: 6 mg/kg/30 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction) TXAPA9 189,214,2003
oral
human
lowest published toxic dose: 37.8 g/kg/3 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 72,242,2003
oral
mouse
lowest published toxic dose: 15 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,19,2003
oral
mouse
lowest published toxic dose: 27 mg/kg/9 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 72,242,2003
oral
mouse
lowest published toxic dose: 0.35 g/kg/5 week- continuous Vascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral
mouse
lowest published toxic dose: 0.7 g/kg/10 week- continuous Vascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral
mouse
lowest published toxic dose: 0.14 g/kg/20 week- continuous Vascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral
mouse
lowest published toxic dose: 0.14 mg/kg/10 week- continuous Vascular: Other changes

Tumorigenic: Facilitates action of known carcinogens

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,236,2004
oral
mouse
lowest published toxic dose: 87.5 mg/kg/5 week- continuous Gastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Other changes
TOLED5 172,91,2007
oral
mouse
lowest published toxic dose: 15 mg/kg/30 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1138,2008
oral
rat
lowest published toxic dose: 1,820 mg/kg/26 week- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
WDZAEK 8,95,1994
oral
rat
lowest published toxic dose: 180 mg/kg/4 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
WDZAEK 4,4,1990
oral
rat
lowest published toxic dose: 900 mg/kg/15 week- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTOTDY 5,91,1983
oral
rat
lowest published toxic dose: 350 g/kg/30 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: K
GISAAA 52(1),21,1987
oral
rat
lowest published toxic dose: 25.2 mg/kg/3 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 72,242,2003
oral
rat
lowest published toxic dose: 22.4 mg/kg/8 week- continuous Gastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,193,2002
unreported route
mouse
lowest published toxic dose: 150 mg/kg/30 day- intermittent Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above
TOXID9 72,167,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,100,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 2,48,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,39,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,100,1987
TOXICOLOGY REVIEW
AMIHAB 21,132,1960
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
PTPAD4 1,189,1976
TOXICOLOGY REVIEW
85DHAX As,-,1977
TOXICOLOGY REVIEW
DRDTO* 7,156,2002
TOXICOLOGY REVIEW
TOLED5 133,1,2002
TOXICOLOGY REVIEW
TOLED5 133,17,2002
TOXICOLOGY REVIEW
TOLED5 145,1,2003
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
CRTXB2 33,215,2003
TOXICOLOGY REVIEW
CREOH* 50,197,2004
TOXICOLOGY REVIEW
ENTOX* -,384,2005
TOXICOLOGY REVIEW
JJATDK 26,191,2006
TOXICOLOGY REVIEW
CRTOEC 19,1,2006
TOXICOLOGY REVIEW
MUREAV 533,65,2003
TOXICOLOGY REVIEW
MUREAV 651,131,2008
TOXICOLOGY REVIEW
MUREAV 533,173,2003
TOXICOLOGY REVIEW
MUREAV 533,183,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
MUREAV 659,293,2008
TOXICOLOGY REVIEW
HBTME* ,367,2007
TOXICOLOGY REVIEW
HBTME* ,213,2007
TOXICOLOGY REVIEW
CNREA8 66,11520,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,100,1998
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - AUSTRALIA Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(As)/m3, OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, continuous1 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3 (resp), short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3 (production), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07570;
Number of Industries 6;
Total Number of Facilities 1,284;
Number of Occupations 6;
Total Number of Employees Exposed 3,980
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07570;
Number of Industries 8;
Total Number of Facilities 107;
Number of Occupations 16;
Total Number of Employees Exposed 4,657;
Total Number of Female Employees Exposed 2,001


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of pesticides, glass, industrial chemicals and drugs
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NIOSH Analytical Method, 1994: Arsenic trioxide as As, 7901
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

52GUAX "Anorganische Stoffe in der Toxikologie and Kriminalistik, Symposium, Mosbach, Fed. Rep. Ger., 1983," Heppenheim, Fed. Rep. Ger., Verlag Dr. Dieter Helm, 1983
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
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HBTME*
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Used in manufacture of pesticides, glass, industrial chemicals and drugs

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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