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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic trioxide

RTECS #

CG3325000

CAS #

1327-53-3

Updated

December 2013

Molecular Weight

197.84

Molecular Formula

As2O3

Synonyms

Acide arsenieux (French)
Anhydride arsenieux (French)
Arsenic blanc (French)
Arsenic oxide
Arsenic sesquioxide
Arsenic trioxide (ACGIH)
Arsenic(III) oxide
Arsenicum album
Arsenigen saure (German)
Arsenious acid
Arsenious oxide
Arsenious trioxide
Arsenite
Arsenolite
Arsenous acid
Arsenous acid anhydride
Arsenous anhydride
Arsenous oxide
Arsenous oxide anhydride
Arsentrioxide
Arsodent
Claudelite
Claudetite
Crude arsenic
Diarsenic trioxide
RCRA waste number P012
White arsenic

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human1200 nmol/LMUREAV 88,73,1981
Cytogenetic Analysisoral/mouse3696 mg/kgCYTOAN 52,445,1987
Cytogenetic Analysisother cell types/mouse28500 µg/m3JJATDK 5,61,1985
Cytogenetic Analysisintraperitoneal/rat25 mg/kg/5D- intermittentMUREAV 587,126,2005
Cytogenetic Analysisintraperitoneal/rat25 mg/kg/5DTOXID9 78,390,2004
Cytogenetic Analysisother cell types/mouse7 µmol/L/4HMUREAV 634,40,2007
Cytogenetic Analysismultiple/other fish6.936 mg/L/24HMUREAV 678,7,2009
Cytogenetic Analysissubcutaneous/mouse51.6 mg/kg/4W- intermittentCALEDQ 268,325,2008
Cytogenetic Analysislymphocyte/human1.4 µmol/L/24HFCTOD7 48,1234,2010
DNA Damagelymphocyte/human1.4 µmol/L/24HFCTOD7 48,1234,2010
DNA Damageother cell types/human20 µmol/L/12HMUTAEX 28,515,2013
DNA Damagefibroblast/human5 µg/L/30MTOXID9 66,123,2002
DNA Damageother cell types/human5 µg/L/30MTOXID9 66,123,2002
DNA Damageoral/mouse0.13 mg/kgTXCYAC 162,171,2001
DNA inhibitionoral/mouse20 mL/kgARGEAR 51,605,1981
DNA inhibitionHeLa cell/human500 µmol/LMUREAV 92,427,1982
DNA repair/Bacillus subtilis50 mmol/LMUREAV 77,109,1980
DNA repairother cell types/human20 µmol/L/12HMUTAEX 28,515,2013
DNA repairother cell types/human6 µmol/L/48HEMMUEG 50,46,2009
micronucleus testliver/human5 µmol/L/24HTXCYAC 198,315,2004
micronucleus testother cell types/human10 nmol/L/24HTOLED5 179,34,2008
micronucleus testother cell types/human0.1 nmol/L/48HTOLED5 179,34,2008
micronucleus testembryo/human0.1 nmol/L/24HTOLED5 179,34,2008
micronucleus testintraperitoneal/rat50 mg/kg/5DMUREAV 577S,1,2005
micronucleus testintraperitoneal/mouse1 mg/kgGNKAA5 20,365,1984
micronucleus testlung/hamster250 nmol/LMUREAV 412,213,1998
micronucleus testintraperitoneal/rat50 mg/kg/5D- intermittentMUREAV 587,126,2005
morphological transformother cell types/mouse0.04 mg/L/12DMUREAV 557,191,2004
mutation in microorganisms/Saccharomyes cerevisiae125 mg/L/18H (+/-enzymatic activation step)MUREAV 653,63,2008
sister chromatid exchangelymphocyte/human2 µg/cm3BCTKAG 19,255,1986
specific locus testintraperitoneal/mouse38 mg/kg/5DMUREAV 513,205,2002
specific locus testother cell types/mouse7 µmol/L/4HMUREAV 634,40,2007
specific locus testoral/rat1.4 mg/kgMUREAV 726,195,2011
specific locus testoral/rat11.2 mg/kg/4W- intermittentMUREAV 726,195,2011
Unscheduled DNA Synthesislung/human1 µmol/LMUREAV 315,11,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 28500 µg/m3/4H (9-12D pregnant)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 5,61,1985
inhalation/mouse 260 µg/m3/4H (9-12D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JJATDK 5,61,1985
intraperitoneal/rat 10 mg/kg (9D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 60,283,1999
intratracheal/rat 20800 µg/kg (8W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NEZAAQ 50,135,1995
oral/mouse 224 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)AEHLAU 23,102,1971
oral/mouse 3636 mg/kg (1-18D pregnant)Reproductive: Effects on fertility: Abortion52GUAX -,91,1983
oral/mouse 8250 µg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Behavioral
CHYCDW 28,20,1994
oral/mouse 1650 µg/kg (7-17D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemCHYCDW 28,20,1994
oral/mouse 315 mg/kg (1-21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72,35,2003
oral/rat 0.756 mg/kg (1-18D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 44,30,2005
oral/woman 600 mg/kg (30W pregnant)Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects
AJDCAI 117,328,1969
oral/rat 30 mg/kg (9D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TJADAB 60,283,1999
oral/rat 330 mg/kg (14D prior to copulation/1-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 38,459,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 50 µg/m3/24Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
HBPTO* 2,1398,2001
intratracheal/hamster toxic dose: 39608 µg/kg/24W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
intratracheal/hamster toxic dose: 55456 µg/kg/24W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JOUOD4 5(Suppl),109,1983
intratracheal/hamster toxic dose: 30 mg/kg/15W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SAIGBL 24,523,1982
intratracheal/hamster lowest published toxic dose: 45 mg/kg/15W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ATSUDG 7,403,1984
intratracheal/hamster toxic dose: 40 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
intratracheal/hamster toxic dose: 55450 µg/kg/15W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CALEDQ 21,141,1983
intratracheal/rat toxic dose: 167 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
SAIGBL 20,230,1978
intratracheal/rat toxic dose: 75 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FKIZA4 71,19,1980
intratracheal/rat lowest published toxic dose: 16 mg/kg/15W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
EVHPAZ 19,191,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 202 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 44 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 22 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 4 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Human, fibroblast Inhibitor Concentration Low: 1 µmol/LIn Vitro Toxicity Studies: Cell countingTXAPA9 250,69,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 2 µmol/L/72HIn Vitro Toxicity Studies: Cell countingTXAPA9 250,69,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 2 µmol/L/8HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTXAPA9 250,69,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 2 µmol/L/24HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 250,69,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 200 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Human, lung tumor Inhibitor Concentration Low: 1 µmol/LIn Vitro Toxicity Studies: Cell countingTXAPA9 250,69,2011
In Vitro/jkcInhibitor Concentration Low: 0.5 µmol/LIn Vitro Toxicity Studies: Cell countingTXAPA9 250,69,2011
In Vitro/jkhInhibitor Concentration (50 percent kill): 100 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/jtiInhibitor Concentration Low: 5 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 244,263,2010
In Vitro/jtiInhibitor Concentration Low: 10 µmol/L/12HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 244,263,2010
In Vitro/jtiInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TXAPA9 244,263,2010
In Vitro/jtiInhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.TXAPA9 244,263,2010
In Vitro/jtiInhibitor Concentration Low: 20 µmol/L/12HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TXAPA9 244,263,2010
In Vitro/mtgInhibitor Concentration Low: 10 µmol/L/48HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TXCYAC 285,142,2011
In Vitro/mtgInhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitro

In Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXCYAC 285,142,2011
In Vitro/mtgInhibitor Concentration Low: 10 µmol/L/12HIn Vitro Toxicity Studies: Cell countingTXCYAC 285,142,2011
In Vitro/paaInhibitor Concentration (50 percent kill): 30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 500 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.JOETD7 134,839,2011
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 0.006 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 0.016 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 0.03 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
intradermal/chicken lowest published lethal dose: 13 mg/kgHBAMAK 4,1306,1935
intradermal/Dog lowest published lethal dose: 2 mg/kgHBAMAK 4,1306,1935
intradermal/pigeon lowest published lethal dose: 100 mg/kgHBAMAK 4,1306,1935
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgVCVN5* -,88,1993
intraperitoneal/rat lethal dose (50 percent kill): 871 mg/kgGTPZAB 19(3),30,1975
intravenous/guinea pig lowest published toxic dose: 0.8 mg/kgCardiac: EKG changes not diagnostic of above

Cardiac: Change in resting or action potential
BCLPT* 98,381,2006
intravenous/mouse lethal dose (50 percent kill): 10700 µg/kgPSEBAA 78,392,1951
intravenous/rabbit lowest published lethal dose: 10560 µg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes
BIZEA2 70,144,1915
intravenous/rat lowest published toxic dose: 3.96 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 66,83,2002
oral/cattle lowest published lethal dose: 30 mg/kgHBAMAK 4,1306,1935
oral/Dog lowest published lethal dose: 10 mg/kgHBAMAK 4,1306,1935
oral/human lowest published lethal dose: 1429 µg/kgYKYUA6 31,1247,1980
oral/human lowest published lethal dose: 1.1 mg/kgGastrointestinal: Nausea or vomiting

Behavioral: Headache

Vascular: BP lowering not characterized in autonomic section
BJDEAZ 149,757,2003
oral/man lowest published toxic dose: 143 mg/kgCardiac: Change in rate

Gastrointestinal: Nausea or vomiting
HETOEA 23,359,2004
oral/man lowest published toxic dose: 8.6 mg/kgCardiac: Pulse rate increased without fall in BP

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
ARTODN 77,63,2003
oral/man lowest published lethal dose: 142.8 mg/kgBrain and Coverings: Changes in circulation

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 41,1,2003
oral/man lowest published lethal dose: 2857 mg/kgBehavioral: Coma

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Renal function tests depressed
JTCTDW 29,131,1991
oral/man lowest published lethal dose: 123 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Nausea or vomiting

Liver: Other changes
JFSCAS 36,1163,1992
oral/man lowest published lethal dose: 114 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
HETOEA 18,640,1999
oral/man lowest published lethal dose: 29 mg/kgBehavioral: Sleep

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea
AEMED3 16,702,1987
oral/man lowest published lethal dose: 286 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Liver: Liver function tests impaired

Musculoskeletal: Other changes
JTCTDW 29,45,1991
oral/man lowest published toxic dose: 14857 µg/kgEye: Visual field changes

Gastrointestinal: Hypermotility, diarrhea

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTCTDW 36,27,1998
oral/man lowest published toxic dose: 2 mg/kgBehavioral: Headache

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting
JTCTDW 39,13,2001
oral/man lowest published toxic dose: 0.057 gm/kgGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria

Blood: Aplastic anemia
HETOEA 28,63,2009
oral/mouse lethal dose (50 percent kill): 20 mg/kgVCVN5* -,88,1993
oral/rabbit lethal dose (50 percent kill): 20190 µg/kgCHYCDW 22,284,1988
oral/rat lethal dose (50 percent kill): 10 mg/kgVCVN5* -,88,1993
oral/woman lowest published toxic dose: 100 mg/kgCardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
JTCTDW 38,471,2000
oral/woman lowest published toxic dose: 0.1 gm/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
oral/woman lowest published toxic dose: 100 mg/kgCardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section

Gastrointestinal: Nausea or vomiting
JTCTDW 38,471,2000
oral/woman lowest published toxic dose: 549 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting

Blood: Changes in bone marrow not included in above
JJAMA* 20,1557,1996
oral/woman lowest published toxic dose: 20 mg/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes

Liver: Other changes
IAEHDW 68,342,1996
oral/woman lowest published toxic dose: 180 mg/kgPeripheral Nerve and Sensation: Paresthesia

Cardiac: EKG changes not diagnostic of above

Liver: Liver function tests impaired
JTCTDW 42,889,2004
subcutaneous/mouse lethal dose (50 percent kill): 9800 µg/kgPSEBAA 78,392,1951
subcutaneous/rat lowest published lethal dose: 8 mg/kgSkin: After topical application: CorrosiveJPETAB 19,337,1922
Tank with water/Limanda lethal concentration (50 percent kill): 43.9 mg/L/48HAQUTO* 7,135,1985
Tank with water/Limanda lethal concentration (50 percent kill): 31.6 mg/L/72HAQUTO* 7,135,1985
Tank with water/Limanda lethal concentration (50 percent kill): 28.5 mg/L/96HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): 83.6 mg/L/24HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): 33.3 mg/L/48HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): 28.5 mg/L/72HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): 27.3 mg/L/96HAQUTO* 7,135,1985
unreported route/human lowest published lethal dose: 0.29 mg/kgVCVN5* -,92,1993
unreported route/man lowest published lethal dose: 2941 µg/kg85DCAI 2,73,1970
unreported route/rat lowest published lethal dose: 8 mg/kgBIZEA2 184,360,1927

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 50 µg/m3/2W- intermittentImmunological Including Allergic: Decrease in humoral immune responseTXAPA9 241,253,2009
inhalation/rabbit lowest published toxic concentration: 0.22 mg/m3/8W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 66,83,2002
inhalation/rat lowest published toxic concentration: 31 µg/m3/24H/22W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes
GISAAA 47(1),6,1982
inhalation/rat lowest published toxic concentration: 500 µg/m3/24H/33D- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 47(11),74,1982
intraperitoneal/rat lowest published toxic dose: 25 mg/kg/5D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 44,379,2005
intratracheal/hamster lowest published toxic dose: 20800 µg/kg/8W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
FKIZA4 91,21,2000
intratracheal/rat lowest published toxic dose: 20800 µg/kg/8W- intermittentLiver: Changes in liver weightNEZAAQ 50,133,1995
intravenous/mouse lowest published toxic dose: 3 mg/kg/5D- intermittentCardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BJPCBM 154,105,2008
intravenous/rabbit lowest published toxic dose: 6 mg/kg/30D- intermittentCardiac: Arrythmias (indlucing changes in conduction)TXAPA9 189,214,2003
oral/human lowest published toxic dose: 37.8 µg/kg/3W- continuousKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 72,242,2003
oral/mouse lowest published toxic dose: 15 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 191,19,2003
oral/mouse lowest published toxic dose: 0.035 µg/kg/5W- continuousVascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral/mouse lowest published toxic dose: 0.07 µg/kg/10W- continuousVascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral/mouse lowest published toxic dose: 0.14 µg/kg/20W- continuousVascular: Structural changes in vessels

Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,170,2004
oral/mouse lowest published toxic dose: 0.14 mg/kg/10W- continuousVascular: Other changes

Tumorigenic: Facilitates action of known carcinogens

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,236,2004
oral/mouse lowest published toxic dose: 87.5 mg/kg/5W- continuousGastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Other changes
TOLED5 172,91,2007
oral/mouse lowest published toxic dose: 15 mg/kg/30D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1138,2008
oral/mouse lowest published toxic dose: 48 mg/kg/60D- continuousBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
NRTXDN 30,538,2009
oral/mouse lowest published toxic dose: 12 mg/kg/60D- continuousBehavioral: Alteration of classical conditioningNETEEC 31,318,2009
oral/mouse lowest published toxic dose: 22.4 mg/kg/28D- continuousBehavioral: Alteration of classical conditioningNETEEC 31,318,2009
oral/mouse lowest published toxic dose: 48 mg/kg/60D- continuousBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
NETEEC 31,318,2009
oral/mouse lowest published toxic dose: 27 mg/kg/9D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 72,242,2003
oral/rat lowest published toxic dose: 22.4 mg/kg/8W- continuousGastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,193,2002
oral/rat lowest published toxic dose: 25.2 mg/kg/3W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 72,242,2003
oral/rat lowest published toxic dose: 1820 mg/kg/26W- continuousBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
WDZAEK 8,95,1994
oral/rat lowest published toxic dose: 180 mg/kg/4D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
WDZAEK 4,4,1990
oral/rat lowest published toxic dose: 900 mg/kg/15W- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTOTDY 5,91,1983
oral/rat lowest published toxic dose: 350 µg/kg/30D- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: K
GISAAA 52(1),21,1987
unreported route/mouse lowest published toxic dose: 150 mg/kg/30D- intermittentCardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above
TOXID9 72,167,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 2,48,1973
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMSUDL 7,100,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 2,48,1973
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,39,1980
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,100,1987
TOXICOLOGY REVIEWAMIHAB 21,132,1960
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWPTPAD4 1,189,1976
TOXICOLOGY REVIEW85DHAX As,-,1977
TOXICOLOGY REVIEWDRDTO* 7,156,2002
TOXICOLOGY REVIEWTOLED5 133,1,2002
TOXICOLOGY REVIEWTOLED5 133,17,2002
TOXICOLOGY REVIEWTOLED5 145,1,2003
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWCRTXB2 33,215,2003
TOXICOLOGY REVIEWCREOH* 50,197,2004
TOXICOLOGY REVIEWENTOX* -,384,2005
TOXICOLOGY REVIEWJJATDK 26,191,2006
TOXICOLOGY REVIEWCRTOEC 19,1,2006
TOXICOLOGY REVIEWMUREAV 533,65,2003
TOXICOLOGY REVIEWMUREAV 651,131,2008
TOXICOLOGY REVIEWMUREAV 533,173,2003
TOXICOLOGY REVIEWMUREAV 533,183,2003
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWMUREAV 659,293,2008
TOXICOLOGY REVIEWHBTME* ,367,2007
TOXICOLOGY REVIEWHBTME* ,213,2007
TOXICOLOGY REVIEWCNREA8 66,11520,2006
TOXICOLOGY REVIEWMUREAV 674,36,2009
TOXICOLOGY REVIEWMUREAV 674,85,2009
TOXICOLOGY REVIEWMUREAV 674,101,2009
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWAEXHE* -,183,1999
TOXICOLOGY REVIEWIMEMDT 84,156,
TOXICOLOGY REVIEWMUREAV 704,115,2010
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNTAPM* -,737,1995
TOXICOLOGY REVIEWMUREAV 714,105,2011
TOXICOLOGY REVIEWMUREAV 750,1,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,100,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(As)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3 (resp), short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3 (production), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 07570; Number of Industries 8; Total Number of Facilities 107; Number of Occupations 16; Total Number of Employees Exposed 4657; Total Number of Female Employees Exposed 2001
National Occupational Hazard Survey 1974Hazard Code 07570; Number of Industries 6; Total Number of Facilities 1284; Number of Occupations 6; Total Number of Employees Exposed 3980

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsenic trioxide as As, 7901
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies; selected, October 2000
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