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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic pentoxide

RTECS #

CG2275000

CAS #

1303-28-2

Updated

September 201

Molecular Weight

229.84

Molecular Formula

As2O5

Synonyms

Anhydride arsenique (French)
Arsenic acid anhydride
Arsenic anhydride
Arsenic(V) oxide
Diarsenic pentoxide
RCRA waste number P011

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human1200 nmol/LMUREAV 88,73,1981
DNA inhibitionfibroblast/human100 µmol/LIVTOE4 1,103,1987
DNA repair/Bacillus subtilis50 mmol/LMUREAV 77,109,1980
sister chromatid exchangefibroblast/hamster3200 µg/LMUREAV 104,141,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 4597 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous/mouse 4597 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/rabbit lowest published lethal dose: 6 mg/kgNTIS** PB214-270
oral/man lowest published lethal dose: 0.043 gm/kgCardiac: EKG changes not diagnostic of above

Cardiac: Other changes

Gastrointestinal: Ulceration or bleeding from stomach
CTOXAO 47,737,2009
oral/mouse lethal dose (50 percent kill): 55 mg/kgIRGGAJ 20,21,1963
oral/rat lethal dose (50 percent kill): 8 mg/kg28ZEAL 5,14,1976
subcutaneous/rabbit lowest published lethal dose: 12400 µg/kgAIPTAK 21,489,1911

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 23,39,1980

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,100,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(As)/m3, NOV2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.03 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(As)/m3, carc 1, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84436; Number of Industries 7; Total Number of Facilities 457; Number of Occupations 11; Total Number of Employees Exposed 14394; Total Number of Female Employees Exposed 5393
National Occupational Hazard Survey 1974Hazard Code 84436; Number of Industries 1; Total Number of Facilities 174; Number of Occupations 2; Total Number of Employees Exposed 1744

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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