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Registry of Toxic Effects of Chemical Substances (RTECS)

Arsenic chloride

RTECS #

CG1750000

CAS #

7784-34-1

Updated

September 201

Molecular Weight

181.27

Molecular Formula

AsCl3

Synonyms

Arsenic butter
Arsenic(III) chloride
Arsenous chloride
Arsenous trichloride (9CI)
Butter of arsenic
Chlorure arsenieux (French)
Chlorure d'arsenic (French)
Fuming liquid arsenic
Trichloroarsine
Trichlorure d'arsenic (French)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisleukocyte/human600 nmol/LMUREAV 88,73,1981
DNA repair/Bacillus subtilis50 mmol/LMUREAV 31,185,1975
micronucleus testother cell types/mammal (species unspecified)200 µmol/LTXCYAC 270,66,2010
micronucleus testintraperitoneal/mouse5500 µg/kgMUREAV 389,3,1997
morphological transformembryo/hamster3 µmol/LCNREA8 39,193,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/kvxInhibitor Concentration Low: 20 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXCYAC 270,66,2010
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration Low: 5 µmol/L/66HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TXCYAC 270,66,2010
inhalation/cat Lowest published lethal concentration: 200 mg/m3/20MHBTXAC 1,324,1955
inhalation/mouse Lowest published lethal concentration: 338 ppm/10MHBTXAC 1,324,1955
oral/rat lethal dose (50 percent kill): 48 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 27(4),54,1983
oral/rat lowest published toxic dose: 330 mg/kgBehavioral: Alteration of classical conditioning

Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes
VCVN5* -,90,1993
oral/rat lethal dose (50 percent kill): 35.7 mg/kgTOVEFN (6),11,2003
oral/rat lowest published toxic dose: 17.85 mg/kgImmunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOVEFN (6),11,2003
oral/rat lowest published toxic dose: 17.85 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesTOVEFN (6),11,2003
skin/rat lethal dose (50 percent kill): 80 mg/kgVCVN5* -,88,1993

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(As)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 mg(As)/m3, carc, MAY2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(As)/m3, carc, OCT2007
Occupational Safety and Health Administration (OSHA)-cancer hazardCFRGBR 29,1910.1018,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-airCarcinogen ceiling concentration 0.002 mg(As)/m3/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 82192; Number of Industries 3; Total Number of Facilities 36; Number of Occupations 3; Total Number of Employees Exposed 1142; Total Number of Female Employees Exposed 152
National Occupational Hazard Survey 1974Hazard Code 82192; Number of Industries 1; Total Number of Facilities 139; Number of Occupations 3; Total Number of Employees Exposed 823

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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