CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Arsenic chloride

RTECS #: CG1750000

CAS #: 7784-34-1


UPDATE: May 2009 MW: 181.27 MF: AsCl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Arsenic butter
  2. Arsenic (III) chloride
  3. Arsenous chloride
  4. Arsenous trichloride (9CI)
  5. Butter of arsenic
  1. Chlorure arsenieux (French)
  2. Chlorure d'arsenic (French)
  3. Fuming liquid arsenic
  4. Trichloroarsine
  5. Trichlorure d'arsenic (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human leukocyte 600 nmol/L MUREAV 88,73,1981
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
micronucleus test intraperitoneal
mouse
5,500 µg/kg MUREAV 389,3,1997
morphological transform hamster embryo 3 µmol/L CNREA8 39,193,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 200 mg/m3/20 minute N/R HBTXAC 1,324,1955
inhalation
mouse
lowest published lethal concentration: 338 ppm/10 minute N/R HBTXAC 1,324,1955
oral
rat
lethal dose (50 percent kill): 48 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 27(4),54,1983
oral
rat
lowest published toxic dose: 330 mg/kg Behavioral: Alteration of classical conditioning

Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes
VCVN5* -,90,1993
oral
rat
lethal dose (50 percent kill): 35.7 mg/kg N/R TOVEFN (6),11,2003
oral
rat
lowest published toxic dose: 17.85 mg/kg Immunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOVEFN (6),11,2003
oral
rat
lowest published toxic dose: 17.85 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases TOVEFN (6),11,2003
skin
rat
lethal dose (50 percent kill): 80 mg/kg N/R VCVN5* -,88,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(As)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1018,1987
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(As)/m3, OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg(As)/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg(As)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(As)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg(As)/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(As)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(As)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ARSENIC, INORGANIC-air Carcinogen ceiling concentration 0.002 mg(As)/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82192;
Number of Industries 1;
Total Number of Facilities 139;
Number of Occupations 3;
Total Number of Employees Exposed 823
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82192;
Number of Industries 3;
Total Number of Facilities 36;
Number of Occupations 3;
Total Number of Employees Exposed 1,142;
Total Number of Female Employees Exposed 152


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the ceramic industry and in the synthesis of chlorine-containing arsenicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in the ceramic industry and in the synthesis of chlorine-containing arsenicals

RTECS Compound Description:
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us