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Registry of Toxic Effects of Chemical Substances (RTECS)

Antipyrine

RTECS #

CD2450000

CAS #

60-80-0

Updated

July 2013

Molecular Weight

188.25

Molecular Formula

C11H12N2O

Synonyms

1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
1-Phenyl-2,3-dimethyl-5-pyrazolone
1-Phenyl-2,3-dimethylpyrazole-5-one
2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one
2,3-Dimethyl-1-phenyl-5-pyrazolone
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-2-phenyl- (9CI)
Analgesine
Anodynin
Anodynine
Antipirin
Antipyrin
Apirelina
Azophen
Azophene
Dimethyloxychinizin
Dimethyloxyquinazine
Fenazon (Czech)
Fenazone
Methozin
Oxydimethylquinazine
Parodyne
Phenazon
Phenazone
Phenazone (pharmaceutical)
Phenazonum
Phenozone
Phenylon
Phenylone
Pyrazophyl
Sedatin
Sedatine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionHeLa cell/human80 mmol/LCRNGDP 13,2389,1992
sister chromatid exchangeintraperitoneal/mouse100 mg/kgMUREAV 420,15,1998

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 361 gm/kg/92W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors
IJCNAW 27,521,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 750 mg/kgAIPTAK 135,376,1962
intravenous/cat lowest published lethal dose: 525 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JPETAB 39,177,1930
intravenous/mouse lethal dose (50 percent kill): 500 mg/kgARZNAD 10,686,1960
intravenous/rabbit lowest published lethal dose: 600 mg/kgHBTXAC 5,14,1959
oral/cat lowest published lethal dose: 1250 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JPETAB 39,177,1930
oral/Dog lowest published lethal dose: 500 mg/kgHBAMAK 4,1304,1935
oral/guinea pig lowest published lethal dose: 1400 mg/kgHBTXAC 5,14,1959
oral/mouse lethal dose (50 percent kill): 1310 mg/kgJAPMA8 45,137,1956
oral/rat lethal dose (50 percent kill): 1705 mg/kgARZNAD 9,401,1959
rectal/cat lowest published lethal dose: 800 mg/kgJAPMA8 33,10,1944
subcutaneous/cat lowest published lethal dose: 700 mg/kgHBAMAK 4,1304,1935
subcutaneous/frog lowest published lethal dose: 2 gm/kgHBAMAK 4,1304,1935
subcutaneous/guinea pig lowest published lethal dose: 1600 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression
AEPPAE 186,195,1937
subcutaneous/mouse lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Analgesia

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
EJPHAZ 538,57,2006
subcutaneous/mouse lethal dose (50 percent kill): 1 gm/kgARZNAD 17,214,1967
subcutaneous/rabbit lowest published lethal dose: 1 gm/kgHBAMAK 4,1304,1935
subcutaneous/rat lowest published lethal dose: 1570 mg/kgAutonomic Nervous System: Other (direct) parasympathomimetic

Cardiac: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
AEPPAE 186,195,1937
unreported route/man lowest published lethal dose: 74 mg/kg85DCAI 2,73,1970

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 144,383,2003
TOXICOLOGY REVIEWTPHSDY 24,524,2003
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,35,1987
TOXICOLOGY REVIEWMUREAV 733,39,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 07420; Number of Industries 4; Total Number of Facilities 163; Number of Occupations 7; Total Number of Employees Exposed 1907; Total Number of Female Employees Exposed 1486
National Occupational Hazard Survey 1974Hazard Code 07420; Number of Industries 3; Total Number of Facilities 41; Number of Occupations 3; Total Number of Employees Exposed 739

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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