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Antipyrine

RTECS #: CD2450000

CAS #: 60-80-0


UPDATE: February 2008 MW: 188.25 MF: C11H12N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2 - Dihydro - 1,5 - dimethyl - 2 - phenyl - 3H - pyrazol - 3 - one
  2. 1 - Phenyl - 2,3 - dimethylpyrazole - 5 - one
  3. 1 - Phenyl - 2,3 - dimethyl - 5 - pyrazolone
  4. 2,3 - Dimethyl - 1 - phenyl - 3 - pyrazolin - 5 - one
  5. 2,3 - Dimethyl - 1 - phenyl - 5 - pyrazolone
  6. 3H - Pyrazol - 3 - one, 1,2 - dihydro - 1,5 - dimethyl - 2 - phenyl - (9CI)
  7. Analgesine
  8. Anodynin
  9. Anodynine
  10. Antipirin
  11. Antipyrin
  12. Apirelina
  13. Azophen
  14. Azophene
  15. Dimethyloxychinizin
  16. Dimethyloxyquinazine
  1. Fenazon (Czech)
  2. Fenazone
  3. Methozin
  4. Oxydimethylquinazine
  5. Parodyne
  6. Phenazon
  7. Phenazone
  8. Phenazonum
  9. Phenazone (pharmaceutical)
  10. Phenozone
  11. Phenylon
  12. Phenylone
  13. Pyrazophyl
  14. Sedatin
  15. Sedatine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition human HeLa cell 80 mmol/L CRNGDP 13,2389,1992
sister chromatid exchange intraperitoneal
mouse
100 mg/kg MUREAV 420,15,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 361 gm/kg/92 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors
IJCNAW 27,521,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 750 mg/kg N/R AIPTAK 135,376,1962
intravenous
cat
lowest published lethal dose: 525 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JPETAB 39,177,1930
intravenous
mouse
lethal dose (50 percent kill): 500 mg/kg N/R ARZNAD 10,686,1960
intravenous
rabbit
lowest published lethal dose: 600 mg/kg N/R HBTXAC 5,14,1959
oral
cat
lowest published lethal dose: 1,250 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JPETAB 39,177,1930
oral
dog
lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1304,1935
oral
guinea pig
lowest published lethal dose: 1,400 mg/kg N/R HBTXAC 5,14,1959
oral
mouse
lethal dose (50 percent kill): 1,310 mg/kg N/R JAPMA8 45,137,1956
oral
rat
lethal dose (50 percent kill): 1,705 mg/kg N/R ARZNAD 9,401,1959
rectal
cat
lowest published lethal dose: 800 mg/kg N/R JAPMA8 33,10,1944
subcutaneous
cat
lowest published lethal dose: 700 mg/kg N/R HBAMAK 4,1304,1935
subcutaneous
frog
lowest published lethal dose: 2 gm/kg N/R HBAMAK 4,1304,1935
subcutaneous
guinea pig
lowest published lethal dose: 1,600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression
AEPPAE 186,195,1937
subcutaneous
mouse
lethal dose (50 percent kill): 1 gm/kg N/R ARZNAD 17,214,1967
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Analgesia

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
EJPHAZ 538,57,2006
subcutaneous
rat
lowest published lethal dose: 1,570 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Cardiac: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
AEPPAE 186,195,1937
subcutaneous
rabbit
lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1304,1935
unreported route
man
lowest published lethal dose: 74 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 144,383,2003
TOXICOLOGY REVIEW
TPHSDY 24,524,2003
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07420;
Number of Industries 3;
Total Number of Facilities 41;
Number of Occupations 3;
Total Number of Employees Exposed 739
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07420;
Number of Industries 4;
Total Number of Facilities 163;
Number of Occupations 7;
Total Number of Employees Exposed 1,907;
Total Number of Female Employees Exposed 1,486


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

Used as an analgesic and antipyretic

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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