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Registry of Toxic Effects of Chemical Substances (RTECS)

Antimony oxide

RTECS #

CC5650000

CAS #

1309-64-4

Updated

September 201

Molecular Weight

291.50

Molecular Formula

O3Sb2

Synonyms

A 1582
A 1588LP
Amspec-KR
Antimonious oxide
Antimony sesquioxide
Antimony trioxide
Antimony trioxide production
Antimony trioxide production (ACGIH)
Antimony White
Antimony(3+) oxide
Antox
AP 50
AT 3
AT 3 (fireproofing agent)
Atox F
Atox S
C.I. 77052
C.I. Pigment White 11
Chemetron fire shield
Dechlorane A-O
Diantimony trioxide
Exitelite
Fireshield FSPO 405
Flowers of antimony
NCI-C55152
Nyacol A 1510LP
Nyacol A 1530
Patox C
Patox H
Patox L
Patox M
Patox S
Stibiox MS
Thermoguard B
Thermoguard L
Thermoguard S
Timonox
Timonox White Star
Twinkling star
Weisspiessglanz (German)
White star

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildNTIS** OTS0555447

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human50 mg/LMUREAV 415,109,1998
DNA Damageinhalation/human0.12 ng/L/1YEMMUEG 40,184,2002
DNA repair/Bacillus subtilis50 mmol/LMUREAV 77,109,1980
sister chromatid exchangelung/hamster90 µg/LMUREAV 264,163,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 270 µg/m3 (1-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(10),85,1987
inhalation/rat 82 µg/m3 (1-21D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
GISAAA 52(10),85,1987
inhalation/rat 270 µg/m3/24H (1-21D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 54(4),68,1989
intratesticular/rat 23320 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 4200 µg/m3/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
AIHAM* 20,1,1980
inhalation/rat toxic concentration (other than lowest): 4 mg/m3/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
PESTC* 8,16,1980
inhalation/rat toxic concentration (other than lowest): 1600 µg/m3/52W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
AIHAM* 20,1,1980
inhalation/rat toxic concentration (other than lowest): 50 mg/m3/7H/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JTEHD6 18,607,1986
inhalation/rat lowest published toxic concentration: 45 mg/m3/52W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,353,2007

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 172 mg/kgENTOX* -,150,2005
intraperitoneal/rat lethal dose (50 percent kill): 3250 mg/kgEQSSDX 1,1,1975
intravenous/Dog lowest published lethal dose: 3 mg/kgHBAMAK 4,1289,1935
oral/rat lethal dose (50 percent kill): >34 gm/kgENTOX* -,150,2005
oral/rat lethal dose (50 percent kill): >34600 mg/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
NTIS** OTS0555447
skin/rabbit lowest published lethal dose: 2 gm/kgNTIS** OTS0555447
subcutaneous/mammal (species unspecified) Lethal dose: >120 mg/kgGTPZAB 8(7),25,1964
subcutaneous/rabbit lowest published lethal dose: 2500 µg/kgHBAMAK 4,1289,1935
subcutaneous/rat lethal dose (50 percent kill): 7904 mg/kgGISAAA 38(1),99,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 45 mg/m3/10W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 27,256,1945
inhalation/mammal (species unspecified) lowest published toxic concentration: 57 mg/m3/24H/26W- continuousBlood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,106,1989
inhalation/rabbit lowest published toxic concentration: 90 mg/m3/56W- intermittentLung, Thorax, or Respiration: Fibrosing alveolitisHBTME* -,353,2007
inhalation/rat lowest published toxic dose: 4.2 mg/m3/1Y- intermittentLung, Thorax, or Respiration: Fibrosing alveolitisHBTME* -,353,2007
inhalation/rat lowest published toxic concentration: 72 µg/m3/24H/17W- continuousBlood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 54(4),68,1989
inhalation/rat lowest published toxic concentration: 4500 µg/m3/6H/1Y- intermittentEye: Other eye effects

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0526425
inhalation/rat lowest published toxic concentration: 2.6 mg/m3/6H/20D- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 78,38,2004
inhalation/rat lowest published toxic concentration: 90 mg/m3/56W- intermittentLung, Thorax, or Respiration: Fibrosing alveolitisHBTME* -,353,2007
oral/rat lowest published toxic dose: 21000 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainEMMUEG 48,621,2007
oral/rat lowest published toxic dose: 152 gm/kg/90D- continuousLiver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 19,205,1999
subcutaneous/rat lowest published toxic dose: 25688 mg/kg/13W- intermittentCardiac: Other changesGISAAA 38(1),99,1973

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possible (production)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 47,291,1989
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 47,291,1989
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 47,291,1989
TOXICOLOGY REVIEWENTOX* -,150,2005
TOXICOLOGY REVIEWHBTME* ,353,2007
TOXICOLOGY REVIEWHTOPA* 1,701,2002
TOXICOLOGY REVIEWMUTAEX 23,191,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.5 mg(Sb)/m3, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.3 mg/m3;KZW 1.2 mg/m3, production, inhal, 2007
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 mg/m3;KZW 0.4 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 mg(Sb)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Sb)/m3 (dust), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 mg(Sb)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.5 mg(Sb)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Sb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg(Sb)/m3 (handling and use), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg/m3 (production), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg/m3 (use and handling), 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Sb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Sb)/m3 (handling and use), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-RUSSIAtime-weighted average 0.2 mg(Sb)/m3, short term exposure limit 0.5 mg(Sb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Sb)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Sb)/m3, carc 2, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg(Sb)/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Sb)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(Sb)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(Sb)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(Sb)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(Sb)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTIMONY-air10H time-weighted average 0.5 mg(Sb)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M2263; Number of Industries 72; Total Number of Facilities 7476; Number of Occupations 76; Total Number of Employees Exposed 209773; Total Number of Female Employees Exposed 56911
National Occupational Hazard Survey 1974Hazard Code M2263; Number of Industries 31; Total Number of Facilities 1540; Number of Occupations 53; Total Number of Employees Exposed 28957

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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