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Antimony oxide

RTECS #: CC5650000

CAS #: 1309-64-4


UPDATE: May 2009 MW: 291.50 MF: O3Sb2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. A 1582
  2. A 1588LP
  3. AP 50
  4. AT 3
  5. AT 3 (fireproofing agent)
  6. Amspec - KR
  7. Antimonious oxide
  8. Antimony White
  9. Antimony sesquioxide
  10. Antimony trioxide
  11. Antimony trioxide production
  12. Antimony trioxide production (ACGIH)
  13. Antimony (3+) oxide
  14. Antox
  15. Atox F
  16. Atox S
  17. C.I. 77052
  18. C.I. Pigment White 11
  19. Chemetron fire shield
  20. Dechlorane A - O
  21. Diantimony trioxide
  1. Exitelite
  2. Fireshield FSPO 405
  3. Flowers of antimony
  4. NCI - C55152
  5. Nyacol A 1510LP
  6. Nyacol A 1530
  7. Patox C
  8. Patox H
  9. Patox L
  10. Patox M
  11. Patox S
  12. Stibiox MS
  13. Thermoguard B
  14. Thermoguard L
  15. Thermoguard S
  16. Timonox
  17. Timonox White Star
  18. Twinkling star
  19. Weisspiessglanz (German)
  20. White star


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild NTIS** OTS0555447


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 50 mg/L MUREAV 415,109,1998
DNA damage inhalation
human
0.12 ng/L/1 year EMMUEG 40,184,2002
DNA repair Bacillus subtilis 50 mmol/L MUREAV 77,109,1980
sister chromatid exchange hamster lung 90 g/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 270 g/m3 (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(10),85,1987
inhalation
rat
lowest published toxic concentration: 82 g/m3 (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
GISAAA 52(10),85,1987
inhalation
rat
lowest published toxic concentration: 270 g/m3/24 hour (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 54(4),68,1989
intratesticular
rat
lowest published toxic dose: 23,320 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4,200 g/m3/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
AIHAM* 20,1,1980
inhalation
rat
toxic concentration (other than lowest) : 4 mg/m3/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
PESTC* 8,16,1980
inhalation
rat
toxic concentration (other than lowest) : 1,600 g/m3/52 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
AIHAM* 20,1,1980
inhalation
rat
toxic concentration (other than lowest) : 50 mg/m3/7 hour/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JTEHD6 18,607,1986
inhalation
rat
lowest published toxic concentration: 45 mg/m3/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HBTME* -,353,2007


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 172 mg/kg N/R ENTOX* -,150,2005
intraperitoneal
rat
lethal dose (50 percent kill): 3,250 mg/kg N/R EQSSDX 1,1,1975
intravenous
dog
lowest published lethal dose: 3 mg/kg N/R HBAMAK 4,1289,1935
oral
rat
lethal dose (50 percent kill): >34,600 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
NTIS** OTS0555447
oral
rat
lethal dose (50 percent kill): >34 gm/kg N/R ENTOX* -,150,2005
subcutaneous
mammal (species unspecified)
lethal dose : >120 mg/kg N/R GTPZAB 8(7),25,1964
subcutaneous
rat
lethal dose (50 percent kill): 7,904 mg/kg N/R GISAAA 38(1),99,1973
subcutaneous
rabbit
lowest published lethal dose: 2,500 g/kg N/R HBAMAK 4,1289,1935
skin
rabbit
lowest published lethal dose: 2 gm/kg N/R NTIS** OTS0555447


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 45 mg/m3/10 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 27,256,1945
inhalation
mammal (species unspecified)
lowest published toxic concentration: 57 mg/m3/24 hour/26 week- continuous Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,106,1989
inhalation
rat
lowest published toxic concentration: 72 g/m3/24 hour/17 week- continuous Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 54(4),68,1989
inhalation
rat
lowest published toxic concentration: 4,500 g/m3/6 hour/1 year- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0526425
inhalation
rat
lowest published toxic concentration: 2.6 mg/m3/6 hour/20 day- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 78,38,2004
inhalation
rat
lowest published toxic concentration: 90 mg/m3/56 week- intermittent Lung, Thorax, or Respiration: Fibrosing alveolitis HBTME* -,353,2007
inhalation
rat
lowest published toxic dose: 4.2 mg/m3/1 year- intermittent Lung, Thorax, or Respiration: Fibrosing alveolitis HBTME* -,353,2007
inhalation
rabbit
lowest published toxic concentration: 90 mg/m3/56 week- intermittent Lung, Thorax, or Respiration: Fibrosing alveolitis HBTME* -,353,2007
oral
rat
lowest published toxic dose: 152 gm/kg/90 day- continuous Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 19,205,1999
oral
rat
lowest published toxic dose: 21,000 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain MUREAV 627,119,2007
subcutaneous
rat
lowest published toxic dose: 25,688 mg/kg/13 week- intermittent Cardiac: Other changes GISAAA 38(1),99,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Sb)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Control as low as possible DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 47,291,1989
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 47,291,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 47,291,1989
TOXICOLOGY REVIEW
ENTOX* -,150,2005
TOXICOLOGY REVIEW
HBTME* ,353,2007
TOXICOLOGY REVIEW
HTOPA* 1,701,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Sb)/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Sb)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg/m3 (inhalable), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.3 mg/m3 (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Sb)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Sb)/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg(Sb)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Sb)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg(Sb)/m3 (handling and use), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 mg/m3 (production), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3 (use and handling), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Sb)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Sb)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Sb)/m3 (handling and use), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg(Sb)/m3, short term exposure limit 0.5 mg(Sb)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Sb)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Sb)/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Sb)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTIMONY-air 10 hour time-weighted average 0.5 mg(Sb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2263;
Number of Industries 31;
Total Number of Facilities 1,540;
Number of Occupations 53;
Total Number of Employees Exposed 28,957
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2263;
Number of Industries 72;
Total Number of Facilities 7,476;
Number of Occupations 76;
Total Number of Employees Exposed 209,773;
Total Number of Female Employees Exposed 56,911


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, dye, pigment and printing ink
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTME*
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PESTC* Pesticide & Toxic Chemical News. (Food Chemical News, Inc., 400 Wyatt Bldg., 777 14th St., NW, Washington, DC 20005) V.1- 1972-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as an industrial chemical, dye, pigment and printing ink

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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