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Antimony (III) chloride

RTECS #: CC4900000

CAS #: 10025-91-9


UPDATE: May 2009 MW: 228.10 MF: Cl3Sb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Antimoine (trichlorure d') (French)
  2. Antimonio (tricloruro di) (Italian)
  3. Antimonous chloride
  4. Antimontrichlorid (German)
  5. Antimony butter
  6. Antimony chloride (Sb2Cl6)
  7. Antimony trichloride
  8. Antimoontrichlride (Dutch)
  1. Butter of antimony
  2. C.I. 77056
  3. Chlorid antimonity (Czech)
  4. Chlorure antimonieux (French)
  5. Stibine, trichloro -
  6. Trichlorostibine
  7. Trichlorure d'antimoine (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 10 mmol/L MUREAV 77,109,1980
micronucleus test hamster lung 10 mol/L MUREAV 412,213,1998
sister chromatid exchange hamster lung 2,500 g/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 1,874 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JANREH 10,15,1996
oral
rat
lowest published toxic dose: 44 mg/kg (1-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TCMUD8 7,491,1987
oral
rat
lowest published toxic dose: 4,400 g/kg (1-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Delayed effects TCMUD8 7,491,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 73 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Cough
HBTME* -,353,2007
inhalation
man
lowest published toxic concentration: 73 mg/m3 Behavioral: Anorexia (human)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes
BJIMAG 23,318,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 13 mg/kg N/R 85GMAT -,23,1982
oral
guinea pig
lethal dose (50 percent kill): 574 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Gastrointestinal: Peritonitis

Gastrointestinal: Necrotic changes
HYSAAV 29(12),16,1964
oral
rat
lethal dose (50 percent kill): 525 mg/kg N/R MarJV# 29MAR1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
guinea pig
lowest published toxic dose: 2,282 mg/kg/9 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in other cell count (unspecified)
GISAAA 29(12),16,1964
oral
guinea pig
lowest published toxic dose: 8,518 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 29(12),16,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Sb)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
HBTME* ,353,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Sb)/m3 DTLVS* 3,15,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Sb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg(Sb)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg(Sb)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Sb)/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg(Sb)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg(Sb)/m3, short term exposure limit 2 mg(Sb)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Sb)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg(Sb)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg(Sb)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg(Sb)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg(Sb)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg(Sb)/m3, MAC(short term exposure limit) 1.5 mg(Sb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg(Sb)/m3, short term exposure limit 0.5 mg(Sb)/m3, JUN2003
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(Sb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Sb)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 mg(Sb)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 mg(Sb)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTIMONY-air 10 hour time-weighted average 0.5 mg(Sb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 07405;
Number of Industries 6;
Total Number of Facilities 125;
Number of Occupations 9;
Total Number of Employees Exposed 1,947
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 07405;
Number of Industries 9;
Total Number of Facilities 344;
Number of Occupations 11;
Total Number of Employees Exposed 22,641;
Total Number of Female Employees Exposed 7,292


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a reagent for CHLORAL, aromatic hydrocarbons, VITAMIN A, and for drug identification
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JANREH Journal of Applied Animal Research. (Garuda Scientific Publications, 151, Janakpuri, Izatnagar, 243122, India) V.1- 1992-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice, Czechoslavakia, Mar. 29, 1977
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used as a reagent for CHLORAL, aromatic hydrocarbons, VITAMIN A, and for drug identification

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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