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Registry of Toxic Effects of Chemical Substances (RTECS)

Anthraquinone, 2-amino-

RTECS #

CB5120000

CAS #

117-79-3

Updated

August 2008

Molecular Weight

223.24

Molecular Formula

C14H9NO2

Synonyms

2-Amino-9,10-anthracenedione
2-Amino-9,10-anthraquinone
2-Aminoanthraquinone
9,10-Anthracenedione, 2-amino- (9CI)
AAQ
Aminoanthraquinone
beta-Aminoanthraquinone
beta-Anthraquinonylamine
NCI-C01876

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testother cell types/mouse6 mg/LEMMUEG 24,96,1994
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms/Escherichia coli1 mg/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 330 gm/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-144,1978
oral/mouse lowest published toxic dose: 655 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
NCITR* NCI-TR-144,1978
oral/mouse toxic dose: 2730 gm/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
IMEMDT 27,191,1982
oral/mouse toxic dose: 5600 gm/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
IMEMDT 27,191,1982
oral/rat toxic dose: 225 gm/kg/78W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-144,1978
oral/rat toxic dose: 32 gm/kg/77W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TOLED5 4,71,1979
oral/rat toxic dose: 1890 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
IMEMDT 27,191,1982
oral/rat toxic dose: 3780 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
IMEMDT 27,191,1982
oral/rat lowest published toxic dose: 115 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-144,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): 1500 mg/kgGTPZAB 21(12),27,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 336 gm/kg/8W- continuousKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria
MDBYAS 58,337,1980
oral/rat lowest published toxic dose: 77 gm/kg/48W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Hyperglycemia

Blood: Pigmented or nucleated red blood cells
TXAPA9 25,453,1973

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 27,191,1982
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,191,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWJTEHD6 8,109,2005

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-144,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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