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Registry of Toxic Effects of Chemical Substances (RTECS)

Anthraquinone

RTECS #

CB4725000

CAS #

84-65-1

Updated

April 2010

Molecular Weight

208.22

Molecular Formula

C14H8O2

Synonyms

9,10-Anthracenedione
9,10-Anthrachinon (Czech)
9,10-Anthraquinone
9,10-Dioxoanthracene
Anthracene, 9,10-dihydro-9,10-dioxo-
Anthradione
Corbit
Hoelite
Morkit

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/mouse250 mg/kgATSUDG 5,355,1982
micronucleus testembryo/hamster12500 µg/LMUREAV 392,61,1997
mutation in microorganisms/Salmonella typhimurium2 µg/plate (+enzymatic activation step)AEMIDF 43,1354,1982
mutation in microorganisms/Salmonella typhimurium333 µg/plate (-enzymatic activation step)EMMUEG 11(Suppl 12),1,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 194775 mg/kg/105W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** NIH No. 99-3953
oral/mouse lowest published toxic dose: 172725 mg/kg/105W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** NIH No. 99-3953
oral/rat lowest published toxic dose: 32760 mg/kg/104W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** NIH No. 99-3953
oral/rat lowest published toxic dose: 36400 mg/kg/104W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** NIH No. 99-3953

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >1300 mg/m3/4HPEMNDP 9,37,1991
intraperitoneal/rat lethal dose (50 percent kill): 3500 mg/kgGTPZAB 21(12),27,1977
intraperitoneal/rat lethal dose (50 percent kill): 3500 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
VCVGK* -,491,1994
oral/mouse lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,37,1991
oral/rat lowest published lethal dose: 15 gm/kg85GMAT -,22,1982
skin/rat lethal dose (50 percent kill): >1 gm/kg85JFAN A019,1983
unreported route/quail lethal dose (50 percent kill): >2 gm/kgFMCHA2 -,C23,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 12.2 mg/m3/122D- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,491,1994
oral/mouse lowest published toxic dose: 328 mg/kg/13W- continuousLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes
TOXID9 15,318,1995
oral/rat lowest published toxic dose: 164 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 15,318,1995
oral/rat lowest published toxic dose: 12200 mg/m3/5H/17W- intermittentLung, Thorax, or Respiration: Emphysema

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 15(2),58,1971

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJTEHD6 8,109,2005
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWCLLID* 11,577,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81710; Number of Industries 5; Total Number of Facilities 435; Number of Occupations 7; Total Number of Employees Exposed 6187; Total Number of Female Employees Exposed 1602
National Occupational Hazard Survey 1974Hazard Code 81710; Number of Industries 4; Total Number of Facilities 81; Number of Occupations 8; Total Number of Employees Exposed 2202

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP Carcinogenesis studies; test completed (post peer review), October 2000
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