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Anthraquinone

RTECS #: CB4725000

CAS #: 84-65-1


UPDATE: February 2009 MW: 208.22 MF: C14H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 9,10 - Anthracenedione
  2. 9,10 - Anthrachinon (Czech)
  3. 9,10 - Anthraquinone
  4. 9,10 - Dioxoanthracene
  5. Anthracene, 9,10 - dihydro - 9,10 - dioxo -
  1. Anthradione
  2. Corbit
  3. Hoelite
  4. Morkit


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage intraperitoneal
mouse
250 mg/kg ATSUDG 5,355,1982
mutation in microorganisms Salmonella typhimurium 2 g/plate (+enzymatic activation step) AEMIDF 43,1354,1982
mutation in microorganisms Salmonella typhimurium 333 g/plate (-enzymatic activation step) EMMUEG 11(Suppl 12),1,1988
micronucleus test hamster embryo 12,500 g/L MUREAV 392,61,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 194,775 mg/kg/105 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** NIH No. 99-3953
oral
mouse
lowest published toxic dose: 172,725 mg/kg/105 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** NIH No. 99-3953
oral
rat
lowest published toxic dose: 32,760 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** NIH No. 99-3953
oral
rat
lowest published toxic dose: 36,400 mg/kg/104 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** NIH No. 99-3953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >1,300 mg/m3/4 hour N/R PEMNDP 9,37,1991
intraperitoneal
rat
lethal dose (50 percent kill): 3,500 mg/kg N/R GTPZAB 21(12),27,1977
intraperitoneal
rat
lethal dose (50 percent kill): 3,500 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
VCVGK* -,491,1994
oral
mouse
lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,37,1991
oral
rat
lowest published lethal dose: 15 gm/kg N/R 85GMAT -,22,1982
skin
rat
lethal dose (50 percent kill): >1 gm/kg N/R 85JFAN A019,1983
unreported route
quail
lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C23,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 12.2 mg/m3/122 day- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,491,1994
oral
mouse
lowest published toxic dose: 328 mg/kg/13 week- continuous Liver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes
TOXID9 15,318,1995
oral
rat
lowest published toxic dose: 164 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 15,318,1995
oral
rat
lowest published toxic dose: 12,200 mg/m3/5 hour/17 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 15(2),58,1971
skin
human
lowest published toxic concentration: 2 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,59,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JTEHD6 8,109,2005
TOXICOLOGY REVIEW
MUREAV 566,49,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81710;
Number of Industries 4;
Total Number of Facilities 81;
Number of Occupations 8;
Total Number of Employees Exposed 2,202
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81710;
Number of Industries 5;
Total Number of Facilities 435;
Number of Occupations 7;
Total Number of Employees Exposed 6,187;
Total Number of Female Employees Exposed 1,602


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as dye
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP Carcinogenesis studies; test completed (post peer review), October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as dye

NIOSH PROFILE (ANTHRAQUINONE), SRI, 9/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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