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Registry of Toxic Effects of Chemical Substances (RTECS)

Anthranilic acid

RTECS #

CB2450000

CAS #

118-92-3

Updated

December 2011

Molecular Weight

137.15

Molecular Formula

C7H7NO2

Synonyms

1-Amino-2-carboxybenzene
2-Aminobenzoic acid
2-Carboxyaniline
Benzoic acid, o-amino-
Carboxyaniline
Kyselina anthranilova (Czech)
Kyselina o-aminobenzoova (Czech)
NCI-C01730
o-Aminobenzoic acid
o-Anthranilic acid
o-Carboxyaniline
Vitamin L

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslymphocyte/human1667 mg/LMUREAV 196,61,1988
mutation in mammalian somatic cellslymphocyte/mouse1266 mg/LEMMUEG 12(Suppl 13),37,1988
mutation in microorganismslymphocyte/mouse250 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),37,1988
sister chromatid exchangeintraperitoneal/mouse600 mg/kgEMMUEG 14,207,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 34800 mg/kg (8D male/21D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)MPHEAE 15,7,1966

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 16 gm/kg/25W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
APMIAL 26,447,1949
subcutaneous/mouse lowest published toxic dose: 1345 mg/kg/21D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors
JCROD7 96,163,1980
subcutaneous/mouse lowest published toxic dose: 2040 mg/kg (13-17D pregnant)Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
JCROD7 96,163,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 2500 mg/kgRPTOAN 37,105,1974
intravenous/mouse lethal dose (50 percent kill): >500 mg/kgYKKZAJ 89,1392,1990
oral/mouse lethal dose (50 percent kill): 1400 mg/kgQJPPAL 19,483,1946
oral/rat lethal dose (50 percent kill): 5410 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
GTPZAB 27(3),52,1983
oral/wild bird lethal dose (50 percent kill): 750 mg/kgAECTCV 12,355,1983
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 6310 mg/kgGISAAA 48(6),22,1983

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 16,265,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 16,265,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 723,101,2011
TOXICOLOGY REVIEWMUREAV 653,99,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4427; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 28

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-36,1978
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