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Registry of Toxic Effects of Chemical Substances (RTECS)

Anthracene

RTECS #

CA9350000

CAS #

120-12-7

Updated

December 2011

Molecular Weight

178.24

Molecular Formula

C14H10

Synonyms

Anthracen (German)
Anthracene technical
Anthracin
Coal tar pitch volatiles:anthracene (OSHA)
Green Oil
Paranaphthalene
Tetra Olive N2G

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /mouse 118 µg mildCALEDQ 4,333,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster15 mg/LESKHA5 (103),64,1985
DNA Damagelymphocyte/mouse47400 nmol/LMUREAV 203,155,1988
DNA Damageliver/rat300 µmol/LSinJF# 26OCT1982
DNA repair/Escherichia coli500 mg/LPMRSDJ 1,195,1981
host-mediated assaySalmonella typhimurium/mouse125 mg/kgJJIND8 62,911,1979
micronucleus testintraperitoneal/mouse100 mg/kgMUREAV 192,185,1987
morphological transformkidney/hamster193 mg/LPMRSDJ 1,626,1981
morphological transformembryo/rat108 µg/plateJJATDK 1,190,1981
morphological transformother cell types/mouse2.5 mg/L/10DMUREAV 725,57,2011
mutation in microorganisms/Salmonella typhimurium0.11 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004
mutation in microorganisms/Salmonella typhimurium100 mg/L/72H (+enzymatic activation step)MUREAV 558,181,2004
mutation in microorganismslymphocyte/mouse500 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
phage inhibition capacity/Escherichia coli500 mg/LPMRSDJ 1,224,1981
specific locus testoral/Drosophila melanogaster1 mmol/LMUREAV 341,235,1995

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 20 gm/kg/79W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
ZEKBAI 60,697,1955
subcutaneous/rat lowest published toxic dose: 3300 mg/kg/33W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
NATWAY 42,159,1955
subcutaneous/rat toxic dose: 660 mg/kg/33W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
ZEKBAI 60,697,1955

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 430 mg/kgPMRSDJ 1,682,1981
oral/mouse lethal dose (50 percent kill): 4900 mg/kgVCVGH* -,233,1990
oral/mouse Lethal dose: >17 gm/kgLiver: Fatty liver degenerationGTPZAB 13(5),59,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 23.1 gm/kg/33W- intermittentTumorigenic: Tumors at site of applicationVCVGH* -,233,1990

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 32,105,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,105,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWTOLED5 140-141,353,2003
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWENTOX* -,144,2005

Standards and Regulations

OrganizationStandardReference
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1491; Number of Industries 4; Total Number of Facilities 149; Number of Occupations 5; Total Number of Employees Exposed 2304

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS in rat liver; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-58
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