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Registry of Toxic Effects of Chemical Substances (RTECS)

Anisole, o-nitro-

RTECS #

BZ8790000

CAS #

91-23-6; 35973-13-8

Updated

July 2013

Molecular Weight

153.15

Molecular Formula

C7H7NO3

Synonyms

1-Methoxy-2-nitrobenzene
2-Methoxynitrobenzene
2-Nitroanisole
Benzene, 1-methoxy-2-nitro- (9CI)
NCI-C60388
o-Nitroanisole
o-Nitrophenyl methyl ether
ortho-Nitrobenzene methyl ether

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster1060 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damageoral/rat250 mg/kgMUREAV 630,28,2007
DNA repair/Bacillus subtilis500 nL/discMUREAV 170,11,1986
mutation in microorganisms/Salmonella typhimurium666 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)SAIGBL 29,34,1987
sister chromatid exchangeovary/hamster123 mg/LEMMUEG 10(Suppl 10),1,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 173 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-416,1993
oral/mouse lowest published toxic dose: 173040 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB94-109758
oral/rat lowest published toxic dose: 9604 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTPTR* NTP-TR-416,1993
oral/rat lowest published toxic dose: 28811.16 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB94-109758
oral/rat lowest published toxic dose: 72100 mg/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB94-109758

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 1300 mg/kgLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes
GISAAA 51(1),85,1986
oral/mouse lethal dose (50 percent kill): 1300 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
VCVGK* -,291,1994
oral/rat lethal dose (50 percent kill): 760 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
VCVGK* -,291,1994
oral/rat lethal dose (50 percent kill): 740 mg/kgLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes
GISAAA 51(1),85,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2772 mg/kg/14D- continuousBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral/mouse lowest published toxic dose: 16380 mg/kg/13W- continuousLiver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral/rat lowest published toxic dose: 4500 mg/kg/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
VCVGK* -,292,1994
oral/rat lowest published toxic dose: 8960 mg/kg/14D- continuousBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral/rat lowest published toxic dose: 27300 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count
NTPTR* NTP-TR-416,1993

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 65,369,1996
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 65,369,1996
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 65,369,1996
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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