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Anisole, o - nitro -

RTECS #: BZ8790000

CAS #: 91-23-6


UPDATE: November 2007 MW: 153.15 MF: C7H7NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 2 - nitrobenzene
  2. 2 - Methoxynitrobenzene
  3. 2 - Nitroanisole
  4. Benzene, 1 - methoxy - 2 - nitro - (9CI)
  1. NCI - C60388
  2. o - Nitroanisole
  3. o - Nitrophenyl methyl ether
  4. ortho - Nitrobenzene methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1,060 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage oral
rat
250 mg/kg MUREAV 630,28,2007
DNA repair Bacillus subtilis 500 nL/disc MUREAV 170,11,1986
mutation in microorganisms Salmonella typhimurium 666 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) SAIGBL 29,34,1987
sister chromatid exchange hamster ovary 123 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 173 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-416,1993
oral
mouse
lowest published toxic dose: 173,040 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB94-109758
oral
rat
lowest published toxic dose: 9,604 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTPTR* NTP-TR-416,1993
oral
rat
lowest published toxic dose: 28,811.16 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB94-109758
oral
rat
lowest published toxic dose: 72,100 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB94-109758


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 1,300 mg/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes
GISAAA 51(1),85,1986
oral
mouse
lethal dose (50 percent kill): 1,300 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
VCVGK* -,291,1994
oral
rat
lethal dose (50 percent kill): 740 mg/kg Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes
GISAAA 51(1),85,1986
oral
rat
lethal dose (50 percent kill): 760 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
VCVGK* -,291,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,772 mg/kg/14 day- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral
mouse
lowest published toxic dose: 16,380 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral
rat
lowest published toxic dose: 8,960 mg/kg/14 day- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-416,1993
oral
rat
lowest published toxic dose: 27,300 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count
NTPTR* NTP-TR-416,1993
oral
rat
lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
VCVGK* -,292,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,369,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,369,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,369,1996
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for various pharmaceuticals
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an intermediate for various pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 35973-13-8
Click Here for Additional Information about RTECS

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