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Registry of Toxic Effects of Chemical Substances (RTECS)

Anisole

RTECS #

BZ8050000

CAS #

100-66-3

Updated

February 2006

Molecular Weight

108.15

Molecular Formula

C7H8O

Synonyms

Benzene, methoxy
Ether, methyl phenyl
Methoxybenzene
Methyl phenyl ether
Phenyl methyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateFCTXAV 17,243,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlymphocyte/human25 µmol/LRCOCB8 54,133,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 200 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,289,1994
inhalation/mouse lowest published toxic concentration: 1880 mg/m3Behavioral: General anestheticVCVGK* -,289,1994
inhalation/mouse lethal concentration (50 percent kill): 3021 mg/m3/2HGTPZAB 28(6),43,1984
inhalation/mouse lethal concentration (50 percent kill): 3020 mg/m3/2HBehavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes
VCVGK* -,289,1994
inhalation/rat lethal concentration (50 percent kill): 8949 mg/m3/2HBehavioral: Ataxia

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes
VCVGK* -,289,1994
inhalation/rat lethal concentration (50 percent kill): >5000 mg/m3GTPZAB 28(6),43,1984
intraperitoneal/rat lowest published lethal dose: 500 mg/kgJAFCAU 17,497,1969
oral/guinea pig lethal dose (50 percent kill): 2500 mg/kgVCVGK* -,289,1994
oral/mouse lethal dose (50 percent kill): 2800 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
JPETAB 88,400,1946
oral/mouse lethal dose (50 percent kill): 2900 mg/kgVCVGK* -,289,1994
oral/rat lethal dose (50 percent kill): 3700 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Hematuria
TXAPA9 6,378,1964
oral/rat lethal dose (50 percent kill): 5290 mg/kgVCVGK* -,289,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 200 mg/m3/122D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,289,1994
oral/rabbit lowest published toxic dose: 118.3 mg/kg/26W- intermittentEndocrine: Other changesVCVGK* -,290,1994
oral/rabbit lowest published toxic dose: 1500 mg/kg/15D- intermittentLiver: Liver function tests impaired

Blood: Changes in other cell count (unspecified)
VCVGK* -,289,1994
oral/rat lowest published toxic dose: 31740 mg/kg/30D- intermittentLiver: Changes in liver weightVCVGK* -,289,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1533; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 2; Total Number of Employees Exposed 469

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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