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o - Anisidine, 5 - methyl -

RTECS #: BZ6720000

CAS #: 120-71-8


UPDATE: February 2009 MW: 137.20 MF: C8H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2 - methoxy - 5 - methylbenzene
  2. 2 - Amino - 4 - methylanisole
  3. 2 - Methoxy - 5 - methylaniline
  4. 2 - Methoxy - 5 - methylbenzenamine
  5. 3 - Amino - p - cresol methyl ether
  6. 3 - Amino - 4 - methoxytoluene
  7. 4 - Methoxy - m - toluidine
  8. 4 - Methyl - 2 - aminoanisole
  9. 5 - Methyl - o - anisidine
  1. Azoic Red 36
  2. Benzenamine, 2 - methoxy - 5 - methyl - (9CI)
  3. C.I. Azoic Red 83
  4. Cresidine
  5. Krezidine
  6. NCI - C02982
  7. m - Amino - p - cresol, methyl ester
  8. p - Cresidine
  9. p - Kresidin (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,721,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,721,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage oral
mouse
595 mg/kg MUREAV 412,155,1998
mutation in microorganisms Escherichia coli 2 mg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 62,500 ng (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
morphological transform mouse fibroblast 5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform rat embryo 31 g/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 355 gm/kg/92 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral
mouse
toxic dose : 1,607 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral
mouse
toxic dose : 2,961 gm/kg/92 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral
mouse
lowest published toxic dose: 72.8 gm/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTOD7 45,55,2007
oral
rat
lowest published toxic dose: 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral
rat
toxic dose : 182 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral
rat
toxic dose : 3,640 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral
rat
toxic dose : 7,280 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral
rat
toxic dose : 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
ANTRD4 1,279,1981
oral
rat
toxic dose : 437 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
ANTRD4 1,279,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): 1,450 mg/kg N/R HURC** -,-,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 72,800 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors
TOXID9 60,279,2001
oral
mouse
lowest published toxic dose: 72,800 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Bladder tumors TOXID9 60,279,2001
oral
mouse
: 11.2 gm/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 45,55,2007
oral
mouse
: 14 gm/kg/5 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 45,55,2007
oral
mouse
: 72.8 gm/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes FCTOD7 45,70,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 27,91,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,91,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,104,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 540,165,2003
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA TRK 0.5 mg/m3, JAN 2006
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Carcinogen, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye, pigment and printing ink
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-142,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ANTRD4 Anticancer Research. (5 Argyropoulou St., Kato Patissia, Athens 907, Greece) V.1- 1981-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HURC** Huntingdon Research Center Reports. (Box 527, Brooklandville, MD 21022)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a dye, pigment and printing ink

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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