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Registry of Toxic Effects of Chemical Substances (RTECS)

o-Anisidine, 5-methyl-

RTECS #

BZ6720000

CAS #

120-71-8

Updated

September 201

Molecular Weight

137.20

Molecular Formula

C8H11NO

Synonyms

1-Amino-2-methoxy-5-methylbenzene
2-Amino-4-methylanisole
2-Methoxy-5-methylaniline
2-Methoxy-5-methylbenzenamine
3-Amino-4-methoxytoluene
3-Amino-p-cresol methyl ether
4-Methoxy-m-toluidine
4-Methyl-2-aminoanisole
5-Methyl-o-anisidine
Azoic Red 36
Benzenamine, 2-methoxy-5-methyl- (9CI)
C.I. Azoic Red 83
Cresidine
Krezidine
m-Amino-p-cresol, methyl ester
NCI-C02982
p-Cresidine
p-Kresidin (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,721,1986
skin /rabbit 500 mg/24H mild85JCAE -,721,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/mouse595 mg/kgMUREAV 412,155,1998
morphological transformfibroblast/mouse5 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
morphological transformembryo/rat31 µg/plateJJATDK 1,190,1981
mutation in microorganisms/Salmonella typhimurium62500 ng (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms/Escherichia coli2 mg/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 355 gm/kg/92W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral/mouse toxic dose: 1607 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral/mouse toxic dose: 2961 gm/kg/92W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral/mouse lowest published toxic dose: 72.8 gm/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTOD7 45,55,2007
oral/rat lowest published toxic dose: 364 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral/rat toxic dose: 364 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
ANTRD4 1,279,1981
oral/rat toxic dose: 437 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
ANTRD4 1,279,1981
oral/rat toxic dose: 7280 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982
oral/rat toxic dose: 182 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NCITR* NCI-TR-142,1979
oral/rat toxic dose: 3640 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
IMEMDT 27,91,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 1450 mg/kgHURC** -,-,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 72800 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors
TOXID9 60,279,2001
oral/mouse lowest published toxic dose: 72800 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Bladder tumorsTOXID9 60,279,2001
oral/mouse : 11.2 gm/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 45,55,2007
oral/mouse : 14 gm/kg/5W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 45,55,2007
oral/mouse : 72.8 gm/kg/26W- intermittentKidney, Ureter, and Bladder: Other changesFCTOD7 45,70,2007

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 27,91,1982
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,91,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 540,165,2003
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.5 mg/m3;KZW 2 mg/m3, skin, 2007
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, carc 2, JAN2011

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-142,1979
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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