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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, m-nitro-

RTECS #

BY6825000

CAS #

99-09-2

Updated

April 2012

Molecular Weight

138.14

Molecular Formula

C6H6N2O2

Synonyms

1-Amino-3-nitrobenzene
3-Nitroaniline
3-Nitrobenzenamine
Amarthol Fast Orange R Base
Azobase MNA
Benzenamine, 3-nitro- (9CI)
C.I. 37030
C.I. Azoic Diazo Component 7
Daito Orange Base R
Devol Orange R
Diazo Fast Orange R
Fast Orange Base R
Fast Orange M Base
Fast Orange MM Base
Fast Orange R Base
Fast Orange R Salt
Hiltonil Fast Orange R Base
m-Aminonitrobenzene
m-Nitroaminobenzene
m-Nitrophenylamine
Naphtoelan Orange R Base
Nitranilin
Orange Base IRGA I

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis5 mg/discMUREAV 170,11,1986
mutation in microorganisms/Salmonella typhimurium500 µg/plate (+enzymatic activation step)IJCMDW 7,277,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/Dog lowest published lethal dose: 70 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
JIDHAN 2,247,1920
oral/guinea pig lethal dose (50 percent kill): 450 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
VKMGA7 6,89,1966
oral/mouse lethal dose (50 percent kill): 308 mg/kgAMRL** TR-72-62,1972
oral/quail lethal dose (50 percent kill): 562 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 535 mg/kgAMRL** TR-72-62,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 420 mg/kg/28D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Normocytic anemia
ESKHA5 (109),72,1991
oral/rat lowest published toxic dose: 2940 mg/kg/3W- intermittentBlood: Other changes

Blood: Changes in erythrocyte (RBC) count
VKMGA7 6,89,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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