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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, o-nitro-

RTECS #

BY6650000

CAS #

88-74-4

Updated

July 2013

Molecular Weight

138.14

Molecular Formula

C6H6N2O2

Synonyms

1-Amino-2-nitrobenzene
2-Nitroaniline
Azoene Fast Orange GR Base
Azogene Fast Orange GR
Azoic Diazo Component 6
Benzene, 1-amino-2-nitro-
Brentamine Fast Orange GR Base
C.I. 37025
C.I. Azoic Diazo Component 6
Devol Orange B
Diazo Fast Orange GR
Fast Orange Base GR
Fast Orange Base JR
Fast Orange GR Base
Fast Orange O Base
Hiltonil Fast Orange GR Base
o-Nitraniline
Orange Base Ciba II
Orange Base IRGA II
Orange Salt Ciba II
Orange Salt IRGA II

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster10 mmol/LMUREAV 320,273,1994
DNA repair/Escherichia coli15500 ng/wellMUREAV 133,161,1984
DNA repair/Bacillus subtilis5 mg/discMUREAV 170,11,1986
micronucleus testoral/mouse738 mg/kgMUREAV 320,273,1994
micronucleus testlung/hamster156 µmol/L/6H (+enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster2500 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)MUREAV 44,9,1977

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV303 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >2529 mg/m3/4HLung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
HPV303 -,-,2003
intraperitoneal/rat lowest published lethal dose: 800 mg/kg85GMAT -,91,1982
oral/guinea pig lethal dose (50 percent kill): 2350 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
VKMGA7 6,89,1966
oral/mouse lethal dose (50 percent kill): 1070 mg/kgGTPZAB 25(8),50,1981
oral/quail lethal dose (50 percent kill): 750 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 1600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
VKMGA7 6,89,1966
oral/rat lethal dose (50 percent kill): 2050 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis

Liver: Other changes
HPV303 -,-,2003
oral/wild bird lethal dose (50 percent kill): 750 mg/kgAECTCV 12,355,1983
skin/rabbit lethal dose (50 percent kill): >7940 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
HPV303 -,-,2003
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 9441 mg/kgGISAAA 48(6),22,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 93 mg/m3/4W- continuousBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in leukocyte (WBC) count
HPV303 -,,2003
inhalation/rat lowest published toxic concentration: 73 mg/m3/4W- continuousLiver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
HPV303 -,,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84091; Number of Industries 2; Total Number of Facilities 54; Number of Occupations 3; Total Number of Employees Exposed 1612; Total Number of Female Employees Exposed 455
National Occupational Hazard Survey 1974Hazard Code 84091; Number of Industries 1; Total Number of Facilities 28; Number of Occupations 2; Total Number of Employees Exposed 336

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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