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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, p-chloro-

RTECS #

BX0700000

CAS #

106-47-8

Updated

July 2013

Molecular Weight

127.58

Molecular Formula

C6H6ClN

Synonyms

1-Amino-4-chlorobenzene
4-Amino-1-chlorobenzene
4-Aminochlorobenzene
4-Chloranilin (Czech)
4-Chloroaniline
4-Chlorobenzenamine
4-Chlorophenylamine
Aniline, 4-chloro-
Benzeneamine, 4-chloro
NCI-C02039
p-Chloraniline
p-Chloroaniline
p-Chlorophenylamine
RCRA waste number P024

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,610,1986
skin /rabbit 500 mg/24H mild85JCAE -,610,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/mouse200 mg/kgMUREAV 440,1,1999
DNA Damagefibroblast/human0.5 mmol/L/1HTOLED5 147,35,2004
DNA Damageliver/human1 mmol/l/48HMUREAV 696,21,2010
DNA Damageother cell types/mouse80 µmol/LMUREAV 715,25,2011
DNA repair/Escherichia coli5 mg/LJJIND8 62,873,1979
micronucleus testlung/hamster1500 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster3000 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testovary/hamster100 µmol/L/3H (+enzymatic activation step)MUREAV 724,7,2011
morphological transformembryo/hamster10 µg/LNCIMAV 58,243,1981
morphological transformembryo/mouse800 µg/LEMMUEG 12,21,1988
morphological transformembryo/rat14500 ng/plateJJATDK 1,190,1981
mutation in mammalian somatic cellslymphocyte/mouse1520 µmol/LMUTAEX 3,193,1988
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
mutation in microorganismslymphocyte/mouse15600 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Aspergillus nidulans200 mg/L (-enzymatic activation step)CJMIAZ 16,369,1970
mutation in microorganisms/Salmonella typhimurium500 mg/L/2H (+enzymatic activation step)EMMUEG 44,329,2004
Unscheduled DNA Synthesisliver/rat5 mg/LMUREAV 97,359,1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 5150 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FCTOD7 29,119,1991
oral/mouse toxic dose: 328 gm/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors
NCITR* NCI-TR-189,1979
oral/rat lowest published toxic dose: 9270 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
FCTOD7 29,119,1991
oral/rat toxic dose: 14 gm/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors

Blood: Tumors
NCITR* NCI-TR-189,1979
oral/rat toxic dose: 18200 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
FCTOD7 25,619,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 4.45 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
inhalation/mouse lethal concentration (12 percent kill): 250 mg/m3/6H85GMAT -,34,1982
inhalation/rat lethal concentration (50 percent kill): 2340 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0546450
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgTSCAT* OTS 206512
intraperitoneal/rat lethal dose (50 percent kill): 420 mg/kgAGGHAR 15,447,1957
intravenous/Dog lowest published lethal dose: 100 mg/kgLung, Thorax, or Respiration: Other changesAEPPAE 244,387,1963
oral/guinea pig lethal dose (50 percent kill): 350 mg/kg85GMAT -,34,1982
oral/mouse lethal dose (50 percent kill): 100 mg/kgNCILB* NCI-E-C-72-3252,1973
oral/quail lethal dose (50 percent kill): 237 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 300 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 32(7),13,1967
oral/rat lowest published toxic dose: 300 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
JAPTO* 23,315,2003
oral/rat lowest published toxic dose: 300 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 23,315,2003
oral/rat lowest published toxic dose: 300 mg/kgLung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 23,315,2003
oral/wild bird lethal dose (50 percent kill): 100 mg/kgTXAPA9 21,315,1972
skin/cat lethal dose (50 percent kill): 239 mg/kgGTPZAB 13(5),29,1969
skin/rabbit lethal dose (50 percent kill): 360 mg/kgSkin: After topical application: Primary irritationAIHAAP 23,95,1962
skin/rat lethal dose (50 percent kill): 3200 mg/kgAGGHAR 15,447,1957
subcutaneous/cat lowest published lethal dose: 125 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia
AHBAAM 110,12,1933

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 30 µg/m3/24H/80D- continuousBehavioral: Muscle contraction or spasticityGISAAA 35(4),44,1970
inhalation/rat lowest published toxic concentration: 1 mg/m3/4H/17W- intermittentBehavioral: Aggression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
GTPZAB 13(5),29,1969
oral/rat lowest published toxic dose: 3367 mg/kg/13W- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Kidney, Ureter, and Bladder: Other changes in urine composition
GISAAA 32(7),13,1967
subcutaneous/rat lowest published toxic dose: 1 gm/kg/10D- intermittentBlood: Other changesFATOAO 35,108,1972

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 57,305,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 57,305,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 57,305,1993
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUREAV 626,135,2007
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUTAEX 23,153,2008
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIATRK-TMW 0.04 ppm (0.2 mg/m3);KZW 0.12 ppm (0.8 mg/m3), skin, 2007
Occupational Exposure Limit-HUNGARYtime-weighted average 0.2 mg/m3, short term exposure limit 0.8 mg/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-POLANDtime-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.3 mg/m3, short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 0.04 ppm (0.2 mg/m3), carc 2, inhal, skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; E coli polA without S9
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,ratNCITR* NCI-TR-189,1979
On EPA IRIS database
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