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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N-ethyl-

RTECS #

BX9780000

CAS #

103-69-5

Updated

April 2012

Molecular Weight

121.20

Molecular Formula

C8H11N

Synonyms

Aethylanilin (German)
Anilinoethane
Benzenamine, N-ethyl- (9CI)
Ethylaniline
Ethylphenylamine
N-Ethylaminobenzene
N-Ethylbenzenamine
N-Ethylbenzenamino

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (-enzymatic activation step)MUREAV 517,187,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >1130 mg/m3/4HEPASR* 8EHQ-0282-0429
inhalation/rat lethal concentration (50 percent kill): 1130 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV300 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 242 mg/kgYKKZAJ 97,1117,1977
intraperitoneal/rat lethal dose (50 percent kill): 180 mg/kgAGGHAR 15,447,1957
oral/mouse lethal dose (50 percent kill): 500 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 478 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 290 mg/kgBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia
HPV300 -,-,2001
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV300 -,-,2001
skin/rat lethal dose (50 percent kill): 1347 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Other changes in urine composition
HPV300 -,-,2001
skin/rat lethal dose (50 percent kill): 4700 mg/kgAGGHAR 15,447,1957
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 600 mg/kgGISAAA 48(6),22,1983

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 741,32,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 84347; Number of Industries 1; Total Number of Facilities 23; Number of Occupations 1; Total Number of Employees Exposed 495

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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