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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, 2,4-dinitro-

RTECS #

BX9100000

CAS #

97-02-9

Updated

November 2007

Molecular Weight

183.14

Molecular Formula

C6H5N3O4

Synonyms

2,4-Dinitraniline
2,4-Dinitroanilin (German)
2,4-Dinitroanilina (Italian)
2,4-Dinitroaniline
2,4-Dinitrobenzenamine
Benzenamine, 2,4-dinitro- (9CI)
NCI-C60753

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,756,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagetestis/rat0.0008 mmol/LEMMUEG 44,179,2004
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium2 µg/plate (-enzymatic activation step)MUREAV 67,1,1979
Unscheduled DNA Synthesisliver/rat50 µmol/LMUREAV 221,263,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1100 µg/m3/4H (1-7D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)GTPZAB 26(6),47,1982
inhalation/rat 17 mg/m3/4H (1-7D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)GTPZAB 26(6),47,1982
inhalation/rat 17 mg/m3/4H (1-7D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathGTPZAB 26(6),47,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 400 mg/kgJAPMA8 48,419,1959
intraperitoneal/rat lowest published lethal dose: 250 mg/kgNCNSA6 5,32,1953
oral/guinea pig lethal dose (50 percent kill): 1050 mg/kgGISAAA 47(10),15,1982
oral/mouse lethal dose (50 percent kill): 370 mg/kgGTPZAB 25(8),50,1981
oral/rat lethal dose (50 percent kill): 285 mg/kgTSCAT* OTS 206512

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,57,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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