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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, o-chloro-

RTECS #

BX0525000

CAS #

95-51-2

Updated

August 2004

Molecular Weight

127.58

Molecular Formula

C6H6ClN

Synonyms

1-Amino-2-chlorobenzene
2-Chloroaniline
2-Chlorobenzenamine
Benzenamine, 2-chloro- (9CI)
Fast Yellow GC Base
o-Chloraniline
o-Chloroaniline

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Escherichia coli500 µg/LJJIND8 62,873,1979
mutation in mammalian somatic cellslung/hamster600 µg/LBLFSBY 39,359,1986
mutation in microorganisms/Aspergillus nidulans200 mg/L (-enzymatic activation step)CJMIAZ 16,369,1970
specific locus testlymphocyte/mouse300 mg/LEMMUEG 17,196,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 797 ppm/4HEye: Corneal damage

Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0571625
oral/mouse lethal dose (50 percent kill): 256 mg/kgGTPZAB 13(5),29,1969
skin/cat lethal dose (50 percent kill): 222 mg/kgGTPZAB 13(5),29,1969
subcutaneous/cat lowest published lethal dose: 310 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
AHBAAM 110,12,1933

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1230 mg/m3/4H/2W- intermittentEye: Other eye effects

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0571672
oral/mouse lowest published toxic dose: 14560 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOXID9 14,394,1994
oral/mouse lowest published toxic dose: 910 mg/kg/13W- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaTOSCF2 69,234,2002
oral/mouse lowest published toxic dose: 7280 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002
oral/mouse lowest published toxic dose: 14560 mg/kg/13W- intermittentCardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002
oral/rat lowest published toxic dose: 14560 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOXID9 14,394,1994
oral/rat lowest published toxic dose: 120 mg/kg/3D- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaTOSCF2 69,234,2002
oral/rat lowest published toxic dose: 1820 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002
oral/rat lowest published toxic dose: 7280 mg/kg/13W- intermittentCardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDtime-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83962; Number of Industries 2; Total Number of Facilities 38; Number of Occupations 3; Total Number of Employees Exposed 18138

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-43, October 2000
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