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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, m-chloro-

RTECS #

BX0350000

CAS #

108-42-9

Updated

September 201

Molecular Weight

127.58

Molecular Formula

C6H6ClN

Synonyms

1-Amino-3-chlorobenzene
3-Chlooranilinen (Dutch)
3-Chloroaniline
3-Chlorobenzenamine
3-Chlorophenylamine
3-Cloroaniline (Italian)
Benzenamine, 3-chloro- (9CI)
Fast Orange GC Base
m-Aminochlorobenzene
m-Chloraniline
m-Chloroaniline
m-Chlorophenylamine
Orange GC Base

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testlung/hamster2500 µmol/L/24H (-enzymatic activation step)MUTAEX 26,709,2011
micronucleus testlung/hamster2500 µmol/L/48H (-enzymatic activation step)MUTAEX 26,709,2011
mutation in mammalian somatic cellslung/hamster300 µg/LBLFSBY 39,359,1986
mutation in microorganisms/Aspergillus nidulans200 mg/L (-enzymatic activation step)CJMIAZ 16,369,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 550 mg/m3/4H85GMAT -,34,1982
inhalation/rat lethal dose (50 percent kill): 150 ppm/4HEye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0555316
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgTSCAT* OTS 206512
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgTSCAT* OTS 206512
intravenous/Dog lowest published lethal dose: 50 mg/kgLung, Thorax, or Respiration: Other changesAEPPAE 244,387,1963
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgGISAAA 31(12),6,1966
oral/mouse lethal dose (50 percent kill): 334 mg/kgGTPZAB 13(5),29,1969
oral/rat lethal dose (50 percent kill): 256 mg/kgGISAAA 31(12),6,1966
skin/cat lethal dose (50 percent kill): 223 mg/kgGTPZAB 13(5),29,1969
skin/guinea pig lethal dose (50 percent kill): 100 mg/kgTSCAT* OTS 206512
skin/rat lethal dose (50 percent kill): 250 mg/kg85GMAT -,34,1982
subcutaneous/cat lowest published lethal dose: 125 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AHBAAM 110,12,1933

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 14560 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOXID9 14,394,1994
oral/mouse lowest published toxic dose: 910 mg/kg/13W- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaTOSCF2 69,234,2002
oral/mouse lowest published toxic dose: 1820 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002
oral/mouse lowest published toxic dose: 14560 mg/kg/13W- intermittentCardiac: Changes in heart weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOSCF2 69,234,2002
oral/rat lowest published toxic dose: 30 mg/kg/3D- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaTOSCF2 69,234,2002
oral/rat lowest published toxic dose: 14560 mg/kg/13W- intermittentCardiac: Changes in heart weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,234,2002
oral/rat lowest published toxic dose: 10 gm/kg/13W- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Kidney, Ureter, and Bladder: Other changes in urine composition
GISAAA 32(7),13,1967
oral/rat lowest published toxic dose: 6125 mg/kg/35W- intermittentBrain and Coverings: Recordings from specific areas of CNSGISAAA 31(12),6,1966

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 23,271,2008
TOXICOLOGY REVIEWMUREAV 752,99,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPANs3 sen, MAY2012
Occupational Exposure Limit-POLANDtime-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4029; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 187

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0193-8687
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-43, October 2000
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