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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, N,N-diethyl-

RTECS #

BX3400000

CAS #

91-66-7

Updated

January 2010

Molecular Weight

149.26

Molecular Formula

C10H15N

Synonyms

Benzenamine, N,N-diethyl- (9CI)
Diaethylanilin (German)
Diethylaniline
Diethylphenylamine
N,N-Diethylaminobenzene
N,N-Diethylanilin (Czech)
N,N-Diethylbenzenamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL mildHPV300 -,-,2001
skin /rabbit 0.5 mL/24H severeHPV300 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangeovary/hamster3 µmol/LMUREAV 395,159,1997

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5000 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV300 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 1920 mg/m3/4HEPASR* 8EHQ-0282-0430
inhalation/rat lethal concentration (50 percent kill): 1920 mg/m3/4HBehavioral: Tremor

Behavioral: Ataxia
HPV300 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 870 mg/kgHPV300 -,-,2001
intraperitoneal/rat lethal dose (50 percent kill): 420 mg/kgAGGHAR 15,447,1957
oral/rabbit lowest published lethal dose: 486 mg/kgHPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 0.65 mL/kgLung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Urine volume increased
HPV300 -,-,2001
oral/rat lethal dose (50 percent kill): 720 mg/kgHPV300 -,-,2001
skin/rat lethal dose (50 percent kill): >5000 mg/kgHPV300 -,-,2001
subcutaneous/guinea pig lowest published lethal dose: 3000 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV300 -,-,2001
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 2570 mg/kgHPV300 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 280 mg/kg/28D- intermittentLiver: Other changes

Blood: Normocytic anemia

Blood: Changes in spleen
HPV300 -,-,2001
oral/rat lowest published toxic dose: 5000 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV300 -,-,2001
parenteral/mouse lowest published toxic dose: 1800 mg/kg/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV300 -,-,2001
subcutaneous/Dog lowest published toxic dose: 0.5 gm/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV300 -,-,2001
subcutaneous/guinea pig lowest published toxic dose: 11000 mg/kg/2D- intermittentPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV300 -,-,2001
subcutaneous/rabbit lowest published toxic dose: 1400 mg/kg/2D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV300 -,-,2001
subcutaneous/rabbit lowest published toxic dose: 1.45 gm/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV300 -,-,2001

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83987; Number of Industries 3; Total Number of Facilities 302; Number of Occupations 5; Total Number of Employees Exposed 3640; Total Number of Female Employees Exposed 777
National Occupational Hazard Survey 1974Hazard Code 83987; Number of Industries 2; Total Number of Facilities 514; Number of Occupations 2; Total Number of Employees Exposed 2387

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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