Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, 2,6-dichloro-4-nitro-

RTECS #

BX2975000

CAS #

99-30-9

Updated

November 2007

Molecular Weight

207.02

Molecular Formula

C6H4Cl2N2O2

Synonyms

2,6-Dichlor-4-nitroanilin (Czech)
2,6-Dichloro-4-nitroaniline
2,6-Dichloro-4-nitrobenzenamine
4-Nitroaniline, 2,6-dichloro-
AL-50
Allisan
Benzenamine, 2,6-dichloro-4-nitro- (9CI)
Bortran
Botran
Botran 45W
CDNA
CNA
DCNA
DCNA (fungicide)
Ditranil
RD-6584
Resisan
U-2069

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium2500 µg/plate (+enzymatic activation step)SAIGBL 29,34,1987
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms/Aspergillus nidulans14 µmol/L (-enzymatic activation step)PHYTAJ 66,217,1976
sex chromosome loss and nondisjunction/Aspergillus nidulans38 µmol/LEVHPAZ 31,81,1979

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 80 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >21600 mg/m3/1HPEMNDP 9,265,1991
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgCSLNX* NX#03022
oral/duck lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,265,1991
oral/guinea pig lethal dose (50 percent kill): 1450 mg/kgPCOC** -,343,1966
oral/mouse lethal dose (50 percent kill): 1500 mg/kgPCOC** -,343,1966
oral/rat lethal dose (50 percent kill): 2400 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TSCAT* OTS 206512
skin/mouse lethal dose (50 percent kill): >5 gm/kgPEMNDP 9,265,1991
skin/rabbit lethal dose (50 percent kill): >2 gm/kgPEMNDP 9,265,1991
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1500 mg/kg30ZDA9 -,87,1971
unreported route/mouse lethal dose (50 percent kill): 4490 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia
GISAAA 54(11),4,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 54600 mg/kg/2Y- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 12,314,1968
oral/rat lowest published toxic dose: 12 gm/kg/60D- intermittentBlood: Methemoglobinemia- CarboxhemoglobinemiaGISAAA 54(11),4,1989
oral/rat lowest published toxic dose: 16 gm/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 54(11),4,1989
oral/rat lowest published toxic dose: 109 gm/kg/2Y- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 12,314,1968

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCRTXB2 1(1),93,1971
TOXICOLOGY REVIEWMUREAV 626,135,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,107,1998

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-aneuploidy; B subtilis rec assay
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP