Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, 3,4-dichloro-

RTECS #

BX2625000

CAS #

95-76-1

Updated

July 2011

Molecular Weight

162.02

Molecular Formula

C6H5Cl2N

Synonyms

1-Amino-3,4-dichlorobenzene
3,4-DCA
3,4-Dichloranilin
3,4-Dichloraniline
3,4-Dichloroaniline
3,4-Dichlorobenzenamine
4,5-Dichloroaniline
Benzenamine, 3,4-dichloro- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,612,1986
eye /rabbit 10 mg mildTSCAT* OTS 215198
skin /rabbit 2 mg/24H severe85JCAE -,612,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Aspergillus nidulans200 mg/L (-enzymatic activation step)CJMIAZ 16,369,1970
sister chromatid exchangelymphocyte/human125 µmol/LMUREAV 226,197,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 65 mg/m3/4HTSCAT* OTS 215198
intraperitoneal/mouse lethal dose (50 percent kill): 310 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
LPPTAK 27,306,1979
intraperitoneal/rat lethal dose (50 percent kill): 280 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
LPPTAK 27,306,1979
oral/guinea pig lethal dose (50 percent kill): 675 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GISAAA 33(4),8,1968
oral/mouse lethal dose (50 percent kill): 740 mg/kgGTPZAB 13(5),29,1969
oral/rabbit lethal dose (50 percent kill): 675 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GISAAA 33(4),8,1968
oral/rat lethal dose (50 percent kill): 545 mg/kgTSCAT* OTS 215198
oral/wild bird lethal dose (50 percent kill): 237 mg/kgAECTCV 12,355,1983
skin/cat lethal dose (50 percent kill): 700 mg/kgGTPZAB 13(5),29,1969
skin/rabbit lowest published lethal dose: 300 mg/kgEye: Lacrimation

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0571586
Tank with water/Other invertebrate lethal concentration (50 percent kill): 61.5 mg/L/24HTIVIEQ 32,271,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 30 µg/m3/24H/14W- continuousBehavioral: Muscle contraction or spasticityGISAAA 35(4),44,1970
oral/rat lowest published toxic dose: 6370 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(4),8,1968
oral/rat lowest published toxic dose: 3640 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
GISAAA 33(4),8,1968

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4030; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 187

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP