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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, 2-chloro-4-nitro-

RTECS #

BX1400000

CAS #

121-87-9

Updated

July 2013

Molecular Weight

172.58

Molecular Formula

C6H5ClN2O2

Synonyms

1-Amino-2-chloro-4-nitrobenzene
2-Chloro-4-nitroaniline
4-Nitro-2-chloroaniline
o-Chloro-p-nitroaniline
Ocpna

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+/-enzymatic activation step)SAIGBL 29,34,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 35.3 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lowest published lethal dose: 500 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
CBCCT* 5,337,1953
intravenous/mouse lethal dose (50 percent kill): 56 mg/kgCBCCT* 6,138,1954
oral/guinea pig lethal dose (50 percent kill): 1800 mg/kgBehavioral: General anestheticNTIS** OTS0536149
oral/mouse lethal dose (50 percent kill): 1250 mg/kgGTPZAB 25(8),50,1981
oral/rat lethal dose (50 percent kill): 6430 mg/kgGTPZAB 25(8),50,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 588,88,2005
TOXICOLOGY REVIEWMUTAEX 23,271,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0882; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 2; Total Number of Employees Exposed 737
National Occupational Hazard Survey 1974Hazard Code M0882; Number of Industries 12; Total Number of Facilities 708; Number of Occupations 9; Total Number of Employees Exposed 2937

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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