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Aniline, p - bromo -

RTECS #: BW9280000

CAS #: 106-40-1


UPDATE: May 2006 MW: 172.04 MF: C6H6BrN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 4 - Bromanilinu (Czech)
  2. 4 - Bromoaniline (9CI)
  3. 4 - Bromobenzenamine
  1. Benzenamine, 4 - bromo - (9CI)
  2. p - Bromoaniline
  3. p - Bromophenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis rat liver 50 Ámol/L ENMUDM 3,11,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 248 mg/kg N/R GISAAA 44(12),19,1979
oral
mouse
lethal dose (50 percent kill): 289 mg/kg N/R GISAAA 44(12),19,1979
oral
rat
lethal dose (50 percent kill): 456 mg/kg N/R CEHYAN 23,168,1978
oral
rat
lowest published toxic dose: 500 mg/kg Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
JAPTO* 23,315,2003
oral
rat
lowest published toxic dose: 500 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 23,315,2003
oral
rat
lowest published toxic dose: 500 mg/kg Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 23,315,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2753;
Number of Industries 1;
Total Number of Facilities 174;
Number of Occupations 2;
Total Number of Employees Exposed 1,744
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2753;
Number of Industries 3;
Total Number of Facilities 184;
Number of Occupations 6;
Total Number of Employees Exposed 4,703;
Total Number of Female Employees Exposed 3,745


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1956-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-

RTECS Compound Description:
   Mutagen

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