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Registry of Toxic Effects of Chemical Substances (RTECS)

Aniline, p-bromo-

RTECS #

BW9280000

CAS #

106-40-1

Updated

May 2006

Molecular Weight

172.04

Molecular Formula

C6H6BrN

Synonyms

4-Bromanilinu (Czech)
4-Bromoaniline (9CI)
4-Bromobenzenamine
Benzenamine, 4-bromo- (9CI)
p-Bromoaniline
p-Bromophenylamine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Unscheduled DNA Synthesisliver/rat50 µmol/LENMUDM 3,11,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 248 mg/kgGISAAA 44(12),19,1979
oral/mouse lethal dose (50 percent kill): 289 mg/kgGISAAA 44(12),19,1979
oral/rat lethal dose (50 percent kill): 456 mg/kgCEHYAN 23,168,1978
oral/rat lowest published toxic dose: 500 mg/kgSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
JAPTO* 23,315,2003
oral/rat lowest published toxic dose: 500 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea
JAPTO* 23,315,2003
oral/rat lowest published toxic dose: 500 mg/kgLung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 23,315,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M2753; Number of Industries 3; Total Number of Facilities 184; Number of Occupations 6; Total Number of Employees Exposed 4703; Total Number of Female Employees Exposed 3745
National Occupational Hazard Survey 1974Hazard Code M2753; Number of Industries 1; Total Number of Facilities 174; Number of Occupations 2; Total Number of Employees Exposed 1744

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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