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Registry of Toxic Effects of Chemical Substances (RTECS)

Ammonium, tetramethyl-, chloride

RTECS #

BS7700000

CAS #

75-57-0

Updated

September 199

Molecular Weight

109.62

Molecular Formula

C4H12N·Cl

Synonyms

Methanaminium, N,N,N-trimethyl-, chloride (9CI)
N,N,N-Trimethylmethanaminium chloride
Tetramethylammonium chloride
Tetramine chloride
USAF AN-8

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgBehavioral: Somnolence (general depressed activity)NTIS** OTS0536975
intraperitoneal/rat lethal dose (50 percent kill): 10 mg/kgBehavioral: Somnolence (general depressed activity)

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0536975
oral/mouse lowest published lethal dose: 125 mg/kgJPMSAE 69,327,1980
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair
NTIS** OTS0536975
subcutaneous/frog lowest published lethal dose: 2 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Cardiac: Other changes
SAPHAO 10,201,1900
subcutaneous/mouse lethal dose (50 percent kill): 40 mg/kgNTIS** ORNL-5576
subcutaneous/rabbit lowest published lethal dose: 6 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes
AIPTAK 7,183,1900
unreported route/guinea pig lowest published lethal dose: 20 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
AIPTAK 7,183,1900
unreported route/mouse lowest published lethal dose: 20 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 7,183,1900

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4596; Number of Industries 2; Total Number of Facilities 41; Number of Occupations 2; Total Number of Employees Exposed 2840; Total Number of Female Employees Exposed 1777

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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