Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Ammonium hydroxide

RTECS #

BQ9625000

CAS #

1336-21-6

Updated

April 2012

Molecular Weight

35.06

Molecular Formula

H5NO

Synonyms

Ammonia aqueous
Ammonia water 29%
Aqua ammonia

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946
eye /rabbit 44 µg severeAROPAW 25,839,1941
eye /rabbit 1 mg/30S rinse severeTXCYAC 23,281,1982

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli10 mg/disc (-enzymatic activation step)ANYAA9 76,475,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human Lowest published lethal concentration: 5000 ppm34ZIAG -,95,1969
inhalation/human lowest published toxic concentration: 408 ppmLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema
JISMAB 61,271,1971
intravenous/mouse lethal dose (50 percent kill): 91 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JCINAO 37,497,1958
intravenous/rabbit lowest published lethal dose: 10 mg/kgHBAMAK 4,1289,1935
oral/cat lowest published lethal dose: 750 mg/kgHBAMAK 4,1289,1935
oral/human lowest published lethal dose: 43 mg/kg34ZIAG -,95,1969
oral/rat lethal dose (50 percent kill): 350 mg/kgGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
parenteral/frog lowest published lethal dose: 2500 mg/kg85IXA4 -,688,1948
subcutaneous/mouse lowest published lethal dose: 160 mg/kg85IXA4 -,688,1948
subcutaneous/rabbit lowest published lethal dose: 200 mg/kg85IXA4 -,688,1948

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWHUTOX* -,671,1996

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (14 mg/m3), short term exposure limit 50 ppm (36 mg/m3), NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 06145; Number of Industries 326; Total Number of Facilities 66188; Number of Occupations 188; Total Number of Employees Exposed 1022551; Total Number of Female Employees Exposed 379643
National Occupational Hazard Survey 1974Hazard Code 06145; Number of Industries 297; Total Number of Facilities 85664; Number of Occupations 161; Total Number of Employees Exposed 735671

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP