CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ammonium, (2 - chloroethyl) trimethyl - , chloride

RTECS #: BP5250000

CAS #: 999-81-5


UPDATE: February 2006 MW: 158.09 MF: C5H13ClNCl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (2 - Chloroethyl) trimethylammonium chloride
  2. (beta - Chloroethyl) trimethylammonium chloride
  3. 2 - Chloraethyl - trimethylammoniumchlorid (German)
  4. 2 - Chloro - N,N,N - trimethylethanaminium chloride
  5. 60 - CS - 16
  6. AC 38555
  7. Antywylegacz
  8. Barleyquat B
  9. Bercema CCC
  10. CCC (plant growth regulant)
  11. Chlorcholinchlorid (Czech)
  12. Chlorcholine chloride
  13. Chlormequat chloride
  14. Chlorocholine chloride
  15. Cycocel
  1. Cycocel Extra
  2. EI 38,555
  3. Ethanaminium, 2 - chloro - N,N,N - trimethyl - , chloride (9CI)
  4. Hico CCC
  5. Hormocel - 2CCC
  6. Increcel
  7. Lihocin
  8. NCI - C02960
  9. Premix
  10. Retacel
  11. Stabilan
  12. TUR
  13. Trimethyl - beta - chlorethylammoniumchlorid (Czech)
  14. WR 62
  15. Zar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild 85JCAE -,616,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition intravaginal
mouse
5 pph JIDEAE 62,378,1974
mutation in microorganisms Escherichia coli 500 mmol/L/30 minute (-enzymatic activation step) MUREAV 40,229,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 7,100 mg/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >5,200 mg/m3/4 hour N/R PEMNDP 9,149,1991
intraperitoneal
mouse
lethal dose (50 percent kill): 62 mg/kg N/R ABMGAJ 27,663,1971
intraperitoneal
rat
lethal dose (50 percent kill): 64 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
ABMGAJ 33,89,1974
intravenous
cat
lowest published lethal dose: 1,200 g/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous
human
lowest published lethal dose: 1 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous
mouse
lethal dose (50 percent kill): 7 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous
rat
lethal dose (50 percent kill): 12,500 g/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous
rabbit
lowest published lethal dose: 4 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
oral
domestic bird
lethal dose (50 percent kill): 261 mg/kg N/R PEMNDP 9,149,1991
oral
cat
lethal dose (50 percent kill): 7 mg/kg N/R AXVMAW 24,1049,1970
oral
chicken
lethal dose (50 percent kill): 920 mg/kg N/R PEMNDP 9,149,1991
oral
dog
lethal dose (50 percent kill): 50 mg/kg N/R AXVMAW 24,1049,1970
oral
human
lowest published lethal dose: 10 mg/kg Autonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
oral
mammal (species unspecified)
lethal dose (50 percent kill): 670 mg/kg N/R GUCHAZ 6,104,1973
oral
mouse
lethal dose (50 percent kill): 54 mg/kg N/R ABMGAJ 27,663,1971
oral
quail
lethal dose (50 percent kill): 555 mg/kg N/R PEMNDP 9,149,1991
oral
rat
lethal dose (50 percent kill): 600 mg/kg N/R GISAAA 36(11),33,1971
oral
rabbit
lethal dose (50 percent kill): 70 mg/kg N/R AXVMAW 31,527,1977
skin
mammal (species unspecified)
lethal dose (50 percent kill): 440 mg/kg N/R GUCHAZ 6,104,1973
skin
rat
lethal dose (50 percent kill): >4 gm/kg N/R PEMNDP 9,149,1991
skin
rabbit
lethal dose (50 percent kill): 232 mg/kg N/R WRPCA2 9,119,1970
unreported route
mouse
lethal dose (50 percent kill): 560 mg/kg N/R VINIT* #4758-80
unreported route
rat
lethal dose (50 percent kill): 780 mg/kg N/R VINIT* #4758-80


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,920 mg/kg/24 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 30,103,1984
oral
rat
lowest published toxic dose: 7,920 mg/kg/72 day- intermittent Endocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 36(11),33,1971
oral
rat
lowest published toxic dose: 15,600 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 43(4),8,1978
oral
rabbit
lowest published toxic dose: 1,092 mg/kg/39 week- intermittent Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight
GISAAA 36(11),33,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,223,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4610;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 2;
Total Number of Employees Exposed 107


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, emulsifier, agricultural chemical and pesticide
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-158,1979


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a solvent, emulsifier, agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 39394-21-3
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us