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Registry of Toxic Effects of Chemical Substances (RTECS)

Ammonium, (2-chloroethyl)trimethyl-, chloride

RTECS #

BP5250000

CAS #

999-81-5; 39394-21-3

Updated

February 2006

Molecular Weight

158.09

Molecular Formula

C5H13ClN·Cl

Synonyms

(2-Chloroethyl)trimethylammonium chloride
(beta-Chloroethyl)trimethylammonium chloride
2-Chloraethyl-trimethylammoniumchlorid (German)
2-Chloro-N,N,N-trimethylethanaminium chloride
60-CS-16
AC 38555
Antywylegacz
Barleyquat B
Bercema CCC
CCC (plant growth regulant)
Chlorcholinchlorid (Czech)
Chlorcholine chloride
Chlormequat chloride
Chlorocholine chloride
Cycocel
Cycocel Extra
EI 38,555
Ethanaminium, 2-chloro-N,N,N-trimethyl-, chloride (9CI)
Hico CCC
Hormocel-2CCC
Increcel
Lihocin
NCI-C02960
Premix
Retacel
Stabilan
Trimethyl-beta-chlorethylammoniumchlorid (Czech)
TUR
WR 62
Zar

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mild85JCAE -,616,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionintravaginal/mouse5 pphJIDEAE 62,378,1974
mutation in microorganisms/Escherichia coli500 mmol/L/30M (-enzymatic activation step)MUREAV 40,229,1976

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 7100 mg/kg/78W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5200 mg/m3/4HPEMNDP 9,149,1991
intraperitoneal/mouse lethal dose (50 percent kill): 62 mg/kgABMGAJ 27,663,1971
intraperitoneal/rat lethal dose (50 percent kill): 64 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
ABMGAJ 33,89,1974
intravenous/cat lowest published lethal dose: 1200 µg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous/human lowest published lethal dose: 1 mg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous/mouse lethal dose (50 percent kill): 7 mg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous/rabbit lowest published lethal dose: 4 mg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
intravenous/rat lethal dose (50 percent kill): 12500 µg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
oral/cat lethal dose (50 percent kill): 7 mg/kgAXVMAW 24,1049,1970
oral/chicken lethal dose (50 percent kill): 920 mg/kgPEMNDP 9,149,1991
oral/Dog lethal dose (50 percent kill): 50 mg/kgAXVMAW 24,1049,1970
oral/domestic bird lethal dose (50 percent kill): 261 mg/kgPEMNDP 9,149,1991
oral/human lowest published lethal dose: 10 mg/kgAutonomic Nervous System: Central sympatholytic

Lung, Thorax, or Respiration: Respiratory depression
AXVMAW 31,527,1977
oral/mammal (species unspecified) lethal dose (50 percent kill): 670 mg/kgGUCHAZ 6,104,1973
oral/mouse lethal dose (50 percent kill): 54 mg/kgABMGAJ 27,663,1971
oral/quail lethal dose (50 percent kill): 555 mg/kgPEMNDP 9,149,1991
oral/rabbit lethal dose (50 percent kill): 70 mg/kgAXVMAW 31,527,1977
oral/rat lethal dose (50 percent kill): 600 mg/kgGISAAA 36(11),33,1971
skin/mammal (species unspecified) lethal dose (50 percent kill): 440 mg/kgGUCHAZ 6,104,1973
skin/rabbit lethal dose (50 percent kill): 232 mg/kgWRPCA2 9,119,1970
skin/rat lethal dose (50 percent kill): >4 gm/kgPEMNDP 9,149,1991
unreported route/mouse lethal dose (50 percent kill): 560 mg/kgVINIT* #4758-80
unreported route/rat lethal dose (50 percent kill): 780 mg/kgVINIT* #4758-80

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1920 mg/kg/24D- continuousLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 30,103,1984
oral/rabbit lowest published toxic dose: 1092 mg/kg/39W- intermittentEndocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight
GISAAA 36(11),33,1971
oral/rat lowest published toxic dose: 7920 mg/kg/72D- intermittentEndocrine: Changes in adrenal weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
GISAAA 36(11),33,1971
oral/rat lowest published toxic dose: 15600 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 43(4),8,1978

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,223,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M4610; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 2; Total Number of Employees Exposed 107

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-158,1979
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