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Registry of Toxic Effects of Chemical Substances (RTECS)

Ammonium, benzyldimethyl(2-(2-(p-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)-,chloride

RTECS #

BO7175000

CAS #

121-54-0

Updated

April 2010

Molecular Weight

448.15

Molecular Formula

C27H42NO2·Cl

Synonyms

Anti-germ 77
Antiseptol
Antiseptol (quarternary compound)
Benzethonium chloride
Benzethonium chloride 1622
Benzyldimethyl(2-(2-(p-(1,1,3,3-tetramethylbutyl)phenoxy)ethoxy)ethyl)ammonium chloride
Benzyldimethyl-p-(1,1,3,3-tetramethylbutyl)phenoxyethoxy-ethylammonium chloride
BZT
Diapp
Diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride
Disilyn
Hyamine
Hyamine 1622
NCI-C61494
Phemeride
Phemerol
Phemerol chloride
Phemithyn
Polymine D
p-tert-Octylphenoxyethoxyethyldimethylbenzylammonium chloride
Quatrachlor
Solamin
Solamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 30 µg severePSTGAW 20,16,1953

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Escherichia coli1500 ng/wellMUREAV 133,161,1984
sister chromatid exchangeembryo/hamster1 mg/LSHIGAZ 74,1365,1987

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 104 mg/kg/1Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
CTOXAO 4,185,1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 7813 µg/kgJACTDZ 4(5),65,1985
intraperitoneal/rat lethal dose (50 percent kill): 16500 µg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
FSDZD4 9,729,1983
intravenous/mouse lethal dose (50 percent kill): 30 mg/kgJAPMA8 40,267,1951
intravenous/rat lethal dose (50 percent kill): 19 mg/kgBehavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Hematuria

Blood: Changes in cell count (unspecified)
SCHSAV 30,147,1954
oral/mouse lethal dose (50 percent kill): 338 mg/kgPSEBAA 120,511,1965
oral/rat lethal dose (50 percent kill): 368 mg/kgPSEBAA 120,511,1965
subcutaneous/rat lethal dose (50 percent kill): 119 mg/kgNTIS** PB195-158
unreported route/rat lethal dose (50 percent kill): 420 mg/kg85KYAH 11,167,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraspinal/pig lowest published toxic dose: 13 mg/kg/7D- intermittentSpinal Cord: Other degenerative changesRAPMFX 24,146,1999
oral/rat lowest published toxic dose: 182 gm/kg/2Y- continuousGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 109,422,1953
skin/mouse lowest published toxic dose: 1200 mg/kg/16D- intermittentCardiac: Changes in heart weight

Endocrine: Changes in thymus weight

Skin: After systemic exposure: Dermatitis, other
NTPTR* NTP-TR-438,1995
skin/mouse lowest published toxic dose: 101 mg/kg/13W- intermittentSkin: After systemic exposure: Dermatitis, otherNTPTR* NTP-TR-438,1995
skin/rat lowest published toxic dose: 60 mg/kg/16D- intermittentEndocrine: Changes in thymus weight

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-438,1995
skin/rat lowest published toxic dose: 203 mg/kg/13W- intermittentSkin: After systemic exposure: Dermatitis, otherNTPTR* NTP-TR-438,1995
subcutaneous/rat lowest published toxic dose: 312 mg/kg/1Y- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainCTOXAO 4(2),185,1971

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 4(5),65,1985
TOXICOLOGY REVIEWDERCL* 27,289,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 25830; Number of Industries 11; Total Number of Facilities 1657; Number of Occupations 20; Total Number of Employees Exposed 26949; Total Number of Female Employees Exposed 18054
National Occupational Hazard Survey 1974Hazard Code 25830; Number of Industries 15; Total Number of Facilities 2975; Number of Occupations 26; Total Number of Employees Exposed 26546

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:mouse,rat
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