CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ammonium, alkyldimethylbenzyl - , chloride

RTECS #: BO3150000

CAS #: 8001-54-5


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alkyl dimethylbenzyl ammonium chloride
  2. Alkyldimethyl (phenylmethyl) quaternary ammonium chlorides
  3. Ammonyx
  4. Arquad dmmcb - 75
  5. BTC
  6. BTC 100
  7. BTC 2565
  8. BTC 50
  9. BTC 50 USP
  10. BTC 65
  11. BTC 65 USP
  12. BTC 824
  13. BTC 8248
  14. BTC 8249
  15. BTC E - 8358
  16. Barquat MB - 50
  17. Bayclean
  18. Benirol
  19. Benzalkonium A
  20. Benzalkonium chloride
  21. Benzalkonium salt
  22. Bio - quat 50 - 24
  23. Bio - quat 50 - 25
  24. Bio - quat 50 - 30
  25. Bio - quat 50 - 40
  26. Bio - quat 50 - 42
  27. Bio - quat 50 - 60
  28. Bio - quat 50 - 65
  29. Bio - quat 80 - 24
  30. Bio - quat 80 - 28
  31. Bio - quat 80 - 40
  1. Bio - quat 80 - 42
  2. Bionol
  3. Cequartyl
  4. Culversan LC 80
  5. Dimanin A
  6. Dodigen 226
  7. Drapolene
  8. Drapolex
  9. Enuclen
  10. Gardiquart SV480
  11. Gardiquat 1450
  12. Genamin KDS
  13. Germicin
  14. Germitol
  15. Intexan LB - 50
  16. Kemamine BAC
  17. Marinol
  18. Mefarol
  19. Neo Germ - I - tol
  20. Onyx BTC (Onyx oil & chem Co)
  21. Osvan
  22. Paralkan
  23. Pheneene germicidal solution and tincture
  24. Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
  25. Quaternium - 1
  26. Romergal CB
  27. Triton K - 60
  28. Vikrol RQ
  29. Zephiral
  30. Zephiran chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
50 g severe AJOPAA 27,1118,1944
eye
monkey
2 mg/24 hour severe TXAPA9 6,701,1964
eye
rabbit
100 g severe AROPAW 34,99,1945
eye
rabbit
1 mg/24 hour severe TXAPA9 6,701,1964
eye
rabbit
10 mg mild TXAPA9 55,501,1980
skin
human
150 g/3 day- intermittent mild 85DKA8 -,127,1977
skin
human
1%/48 hour moderate ADVEA4 95,711,1990
skin
human
3%/24 hour mild ADVEA4 68,192,1988
skin
human
6%/2 week BJDEAZ 148,171,2003
skin
rabbit
50 mg/24 hour moderate 33NFA8 -,2,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 50 g/L MUREAV 193,21,1988
sister chromatid exchange hamster embryo 1 mg/L SHIGAZ 74,1365,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravaginal
rat
lowest published toxic dose: 50 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JJATDK 5,398,1985
intravaginal
rat
lowest published toxic dose: 100 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
JJATDK 5,398,1985
intravaginal
rat
lowest published toxic dose: 200 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JJATDK 5,398,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraarterial
rat
lowest published lethal dose: 15 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOLED5 148,113,2004
intraperitoneal
rat
lethal dose (50 percent kill): 14,500 g/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from small intestine
KSRNAM 4,219,1970
intravaginal
pig
lowest published toxic dose: 0.12 gm/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOPADD 33,465,2005
intravenous
rat
lethal dose (50 percent kill): 13,900 g/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KSRNAM 4,219,1970
intravenous
rat
lowest published lethal dose: 15 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOLED5 148,113,2004
oral
rat
lethal dose (50 percent kill): 240 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting
KSRNAM 4,219,1970
oral
rat
lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
TOLED5 148,113,2004
oral
woman
lowest published toxic dose: 266 mg/kg Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Hypermotility, diarrhea
HUTODJ 7,191,1988
subcutaneous
mouse
lethal dose (50 percent kill): 64 mg/kg Behavioral: Somnolence (general depressed activity) KSRNAM 4,219,1970
subcutaneous
rat
lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity) KSRNAM 4,219,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravaginal
pig
lowest published toxic dose: 0.48 gm/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOPADD 33,465,2005
oral
dog
lowest published toxic dose: 13,125 mg/kg/15 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 40,263,1951
oral
rat
lowest published toxic dose: 274 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPMA8 40,263,1951
skin
guinea pig
lowest published toxic dose: 300 g/kg/3 day- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 2,63,1983
unreported route
rat
lowest published toxic dose: 3,136 nL/kg/4 week- intermittent Olfaction: Other olfaction effects LARYA8 110(2 Pt1),312,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ARTODN 32,245,1974
TOXICOLOGY REVIEW
JACTDZ 8(4),589,1989
TOXICOLOGY REVIEW
JTCTDW 38,347,2000
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,77,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1554;
Number of Industries 23;
Total Number of Facilities 1,244;
Number of Occupations 13;
Total Number of Employees Exposed 52,380
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1554;
Number of Industries 125;
Total Number of Facilities 18,923;
Number of Occupations 80;
Total Number of Employees Exposed 486,761;
Total Number of Female Employees Exposed 309,834


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

33NFA8 "Animal Models in Dermatology: Relevance to Human Dermatopharmacology and Dermatotoxicology," Maibach, H., ed., New York, Churchill Livingston, 1975
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADVEA4 Acta Dermato-Venereologica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1920-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
HUTOX*
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
LARYA8 Laryngoscope. (Laryngoscope Co., 9216 Clayton Rd., Suite 18, St. Louis, MO 63124) V.1- 1896-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to control algae and bacteria in swimming pools, cooling systems, etc.

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 8011-91-4
ALT CAS #: 8036-90-6
ALT CAS #: 8039-63-2
ALT CAS #: 8045-21-4
ALT CAS #: 12741-06-9
ALT CAS #: 39434-18-9
ALT CAS #: 59890-14-1
ALT CAS #: 75635-12-0
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us